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已发表论文
常规超声联合剪切波弹性成像对心血管疾病患者肌少症的价值
Authors Shou J, Ouyang C, Lin J, Huang J, Yang H, He Y
Received 11 July 2025
Accepted for publication 2 December 2025
Published 19 December 2025 Volume 2025:20 Pages 2627—2639
DOI https://doi.org/10.2147/CIA.S553232
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Maddalena Illario
Jiali Shou,1,* Chenghu Ouyang,2,* Jiaying Lin,1 Jianmei Huang,1 Huihui Yang,1 Yu He1
1Department of Ultrasound Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Department of Nuclear Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yu He; Huihui Yang, Email 2022683036@gzhmu.edu.cn; 2020683109@gzhmu.edu.cn
Purpose: To investigate the value of conventional ultrasound combined with shear wave elastography (SWE) for sarcopenia in patients with cardiovascular disease (CVD).
Methods: 114 CVD patients were enrolled in this study, where CVD was defined as physician-diagnosed heart disease and/or stroke. Appendicular skeletal muscle mass index (ASMI), calf circumference, grip strength, and 6-m walking speed were measured. Patients were categorized into non-sarcopenia (n=78) and sarcopenia (n=36) groups. Conventional ultrasound and SWE features were measured in relaxed and passive stretched states, and the presence of flaky myosteatosis echo (FE) in rectus femoris (RF) was evaluated. The differences in clinical indicators, conventional ultrasound and SWE features between the two group were analyzed. The Spearman correlation analysis was used to assess the relationship between clinical indicators and conventional ultrasound/SWE features. Independent predictors of sarcopenia were subsequently, and a combined diagnostic model was established by binary logistic regression analysis based on these predictors.
Results: The sarcopenia group exhibited significantly lower subcutaneous adipose tissue thickness (T/SATrelaxed), thickness (T/RFrelaxed, T/RFstretched), cross-sectional area (CSA/RFrelaxed, CSA/RFstretched, ΔCSA) of RF, and the thickness of RF and vastus intermedius [T/(RF+VI)relaxed,T/(RF+VI)stretched], but significantly higher presence of FE/RF compared to the non-sarcopenia group. In terms of SWE features, patients with sarcopenia exhibited significantly lower shear wave velocities (SWV) in the RF (SWV/RFrelaxed, SWV/RFstretched) and VI (SWV/VIrelaxed, SWV/VIstretched), as well as the difference in SWV between the two states (ΔSWV/RF, ΔSWV/VI). Finally, the prediction model for sarcopenia in patients with CVD incorporating T/SATrelaxed, T/RFstretched, ΔSWV/RF, and SWV/VIstretched was established, with a sensitivity of 83.3%, specificity of 89.7% and cutoff value of 0.381.
Conclusion: Conventional ultrasound combined with SWE provides a novel and quantitative approach for visualizing alterations in muscle mass and stiffness, facilitating early identification of sarcopenia in CVD patients and offering reliable imaging evidence for clinical intervention.
Keywords: sarcopenia, ultrasound, shear wave elastography, cardiovascular disease
1Department of Ultrasound Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Department of Nuclear Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yu He; Huihui Yang, Email 2022683036@gzhmu.edu.cn; 2020683109@gzhmu.edu.cn
Purpose: To investigate the value of conventional ultrasound combined with shear wave elastography (SWE) for sarcopenia in patients with cardiovascular disease (CVD).
Methods: 114 CVD patients were enrolled in this study, where CVD was defined as physician-diagnosed heart disease and/or stroke. Appendicular skeletal muscle mass index (ASMI), calf circumference, grip strength, and 6-m walking speed were measured. Patients were categorized into non-sarcopenia (n=78) and sarcopenia (n=36) groups. Conventional ultrasound and SWE features were measured in relaxed and passive stretched states, and the presence of flaky myosteatosis echo (FE) in rectus femoris (RF) was evaluated. The differences in clinical indicators, conventional ultrasound and SWE features between the two group were analyzed. The Spearman correlation analysis was used to assess the relationship between clinical indicators and conventional ultrasound/SWE features. Independent predictors of sarcopenia were subsequently, and a combined diagnostic model was established by binary logistic regression analysis based on these predictors.
Results: The sarcopenia group exhibited significantly lower subcutaneous adipose tissue thickness (T/SATrelaxed), thickness (T/RFrelaxed, T/RFstretched), cross-sectional area (CSA/RFrelaxed, CSA/RFstretched, ΔCSA) of RF, and the thickness of RF and vastus intermedius [T/(RF+VI)relaxed,T/(RF+VI)stretched], but significantly higher presence of FE/RF compared to the non-sarcopenia group. In terms of SWE features, patients with sarcopenia exhibited significantly lower shear wave velocities (SWV) in the RF (SWV/RFrelaxed, SWV/RFstretched) and VI (SWV/VIrelaxed, SWV/VIstretched), as well as the difference in SWV between the two states (ΔSWV/RF, ΔSWV/VI). Finally, the prediction model for sarcopenia in patients with CVD incorporating T/SATrelaxed, T/RFstretched, ΔSWV/RF, and SWV/VIstretched was established, with a sensitivity of 83.3%, specificity of 89.7% and cutoff value of 0.381.
Conclusion: Conventional ultrasound combined with SWE provides a novel and quantitative approach for visualizing alterations in muscle mass and stiffness, facilitating early identification of sarcopenia in CVD patients and offering reliable imaging evidence for clinical intervention.
Keywords: sarcopenia, ultrasound, shear wave elastography, cardiovascular disease