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已发表论文
聚多巴胺功能化石墨烯氧化物可提高生物安全性并增强化疗-光热治疗协同抗癌效果
Authors Ma W , Zhang Y, Zhai X, Qu Q, Guo X, Zhang S, Hou R , Lu P, Yin Y
Received 7 July 2025
Accepted for publication 4 December 2025
Published 19 December 2025 Volume 2025:20 Pages 15363—15377
DOI https://doi.org/10.2147/IJN.S552175
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Professor Dong Wang
Weiwei Ma,1,* Yan Zhang,2,* Xuejing Zhai,1 Qian Qu,1 Xueying Guo,1 Sen Zhang,1 Ruiyao Hou,1 Ping Lu,2 Yanyan Yin1
1College of Pharmacy, Xinxiang Medical University, Xinxiang, People’s Republic of China; 2Department of Oncology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Weiwei Ma, College of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, People’s Republic of China, Tel/Fax +86 0373 3029879, Email 081011@xxmu.edu.cn Yanyan Yin, Email 105772801@qq.com
Background: Graphene oxide (GO) has high drug-loading capacity and good photothermal property. However, the limited stability and poor biocompatibility of GO hindered its application as drug delivery carrier for future nanomedicine.
Methods: In this study, a new strategy of using chemical conjugation on GO with polypeptide was adopted. A novel Biotin grafted polysarcosine polymers (B-PSar) modified graphene oxide derivative (B-PSar-GO) was successfully synthesized and utilized as a carrier to develop a new drug delivery system for targeted chemo-photothermal cancer therapy. In vitro and in vivo experiments evaluated the system’s biosafety and antitumor efficacy.
Results: With the B-PSar protection, the B-PSar-GO showed excellent biological safety with the average size of 268.2± 8.4 nm. Stability experiments displayed B-PSar-GO was extremely stable. The anti-cancer drug doxorubicin (DOX) was loaded on B-PSar-GO through π–π interactions and hydrophobic interactions, B-PSar-GO@DOX achieved a maximum loading capacity of 25.5%. In addition, B-PSar-GO@DOX exhibited NIR/pH dual-responsive DOX release characteristics, ensuring sustained drug release to tumor tissues triggered by NIR laser irradiation and acidic tumor microenvironment. Based on the excellent photothermal conversion efficiency of GO, B-PSar-GO@DOX showed excellent chemo-photothermal synergistic tumor inhibition both in vitro and in vivo under NIR irradiation.
Conclusion: The novel nano-drug delivery system B-PSar-GO@DOX developed in this paper offers a promising platform for chemo-photothermal synergistic cancer treatment.
Keywords: polysarcosine, graphene oxide, photothermal-chemotherapy, NIR/pH dual-responsive, drug delivery system
1College of Pharmacy, Xinxiang Medical University, Xinxiang, People’s Republic of China; 2Department of Oncology, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Weiwei Ma, College of Pharmacy, Xinxiang Medical University, Xinxiang, 453003, People’s Republic of China, Tel/Fax +86 0373 3029879, Email 081011@xxmu.edu.cn Yanyan Yin, Email 105772801@qq.com
Background: Graphene oxide (GO) has high drug-loading capacity and good photothermal property. However, the limited stability and poor biocompatibility of GO hindered its application as drug delivery carrier for future nanomedicine.
Methods: In this study, a new strategy of using chemical conjugation on GO with polypeptide was adopted. A novel Biotin grafted polysarcosine polymers (B-PSar) modified graphene oxide derivative (B-PSar-GO) was successfully synthesized and utilized as a carrier to develop a new drug delivery system for targeted chemo-photothermal cancer therapy. In vitro and in vivo experiments evaluated the system’s biosafety and antitumor efficacy.
Results: With the B-PSar protection, the B-PSar-GO showed excellent biological safety with the average size of 268.2± 8.4 nm. Stability experiments displayed B-PSar-GO was extremely stable. The anti-cancer drug doxorubicin (DOX) was loaded on B-PSar-GO through π–π interactions and hydrophobic interactions, B-PSar-GO@DOX achieved a maximum loading capacity of 25.5%. In addition, B-PSar-GO@DOX exhibited NIR/pH dual-responsive DOX release characteristics, ensuring sustained drug release to tumor tissues triggered by NIR laser irradiation and acidic tumor microenvironment. Based on the excellent photothermal conversion efficiency of GO, B-PSar-GO@DOX showed excellent chemo-photothermal synergistic tumor inhibition both in vitro and in vivo under NIR irradiation.
Conclusion: The novel nano-drug delivery system B-PSar-GO@DOX developed in this paper offers a promising platform for chemo-photothermal synergistic cancer treatment.
Keywords: polysarcosine, graphene oxide, photothermal-chemotherapy, NIR/pH dual-responsive, drug delivery system