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已发表论文
广泛性毛囊角化性痣采用梳状皮瓣修复、超张力减张缝合及负压封闭引流治疗：1 例报告
Authors Cheng H, Li X, Li X, Bai Y, Zhang W, Zhao B, Yang T , Li P, Yao W
Received 16 October 2025
Accepted for publication 16 December 2025
Published 20 December 2025 Volume 2025:18 Pages 3533—3536
DOI https://doi.org/10.2147/CCID.S574723
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Monica K. Li
Hui Cheng, Xiaojing Li, Xinyi Li, Yun Bai, Wei Zhang, Boao Zhao, Tao Yang, Ping Li, Wende Yao
Department of Plastic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China
Correspondence: Wende Yao, Department of Plastic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China, Email yaowende2020@126.com
Purpose: There are few reports on the comprehensive surgical management of extensive nevus comedonicus, and the genetic mechanism of this rare disease is not yet fully understood.
Patients and Methods: We report a case of a 38-year-old woman with extensive nevus comedonicus, refractory to multiple medical treatments. She underwent comb flap reconstruction combined with super tension-relieving sutures and vacuum sealing drainage. In addition, whole-exome sequencing was performed on the lesional tissue samples.
Results: Nevus comedonicus was confirmed by physical and histopathological examination. Postoperative recovery was uneventful, and the patient was satisfied with the efficacy. Furthermore, no rare or deleterious mutations were detected in NEK9, FGFR2, ABCA12, or KRT10.
Conclusion: Comprehensive surgical intervention is a viable therapeutic option for extensive nevus comedonicus refractory to medical management. Further investigation into the underlying genetic mechanisms of this disease is warranted.
Keywords: nevus comedonicus, whole-exome sequencing, surgical management, super tension-relieving sutures, vacuum sealing drainage
Department of Plastic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China
Correspondence: Wende Yao, Department of Plastic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China, Email yaowende2020@126.com
Purpose: There are few reports on the comprehensive surgical management of extensive nevus comedonicus, and the genetic mechanism of this rare disease is not yet fully understood.
Patients and Methods: We report a case of a 38-year-old woman with extensive nevus comedonicus, refractory to multiple medical treatments. She underwent comb flap reconstruction combined with super tension-relieving sutures and vacuum sealing drainage. In addition, whole-exome sequencing was performed on the lesional tissue samples.
Results: Nevus comedonicus was confirmed by physical and histopathological examination. Postoperative recovery was uneventful, and the patient was satisfied with the efficacy. Furthermore, no rare or deleterious mutations were detected in NEK9, FGFR2, ABCA12, or KRT10.
Conclusion: Comprehensive surgical intervention is a viable therapeutic option for extensive nevus comedonicus refractory to medical management. Further investigation into the underlying genetic mechanisms of this disease is warranted.
Keywords: nevus comedonicus, whole-exome sequencing, surgical management, super tension-relieving sutures, vacuum sealing drainage