114027
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
丙泊酚舒芬太尼与丙泊酚芬太尼在老年前列腺电切术患者中的比较有效性
Received 24 June 2025
Accepted for publication 19 November 2025
Published 20 December 2025 Volume 2025:21 Pages 1773—1782
DOI https://doi.org/10.2147/TCRM.S549323
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Faustino Ramón Pérez-López
Tong Dong,1 Song Lei,2 Genfeng Ding1
1Department of Anesthesiology and Surgery, First People’s Hospital of Yongkang City, Yongkang City, Zhejiang Province, 321300, People’s Republic of China; 2Department of Medical Oncology, First People’s Hospital of Yongkang City, Yongkang City, Zhejiang Province, 321300, People’s Republic of China
Correspondence: Tong Dong, Department of Anesthesiology and Surgery, First People’s Hospital of Yongkang City, No. 599 Jinshan West Road, Yongkang City, Zhejiang Province, 321300, People’s Republic of China, Email 15867932663@163.com
Objective: The aim of this study is to compare the anesthetic effect and cognitive function impact of propofol-sufentanil (PS) versus propofol-fentanyl (PF) in elderly patients undergoing transurethral resection of the prostate (TURP) under general anesthesia (GA).
Methods: This is a retrospective cohort study conducted in First People’s Hospital of Yongkang City. They included 98 patients aged 65 and above who underwent TURP under GA between October 2023 and March 2025. 49 patients who received PS were matched with a cohort of propofol-fentanyl (PF) in a 1:1 ratio. Compare the hemodynamic parameters (heart rate (HR) and mean arterial pressure (MAP)) of two groups at 30 minutes before anesthesia induction (T0), after anesthesia completion (T1), at the time of skin incision (T2), at the end of surgery (T3), at the postanesthesia care unit (PACU) (T4), 15 minutes after PACU arrival (T5), and 30 minutes after PACU arrival (T6). Compare two perioperative indicators (anesthesia onset time, postoperative awakening time, and extubation time). Compare the pain visual analogue scale (VAS) scores of two groups at three, 12, and 24 hours after surgery. And the Montreal Cognitive Assessment Scale (MoCA) was used to evaluate the number of patients with cognitive impairment at six, 24, and 72 hours after surgery in two groups. Compare the incidence of adverse reactions within 72 hours after surgery between two groups.
Results: Compared with the PF group, the PS group had more stable hemodynamics during T2-T5 (P< 0.05); VAS scores were lower at 12 and 24 hours postoperatively (P< 0.05); The anesthesia onset time, postoperative awakening time, and extubation time of the PS group were significantly shorter than those of the PF group (P< 0.05); The incidence of cognitive dysfunction was lower at six and 24 hours after surgery (P< 0.05). However, there was no significant difference in the incidence of various complications between the two groups (P> 0.05).
Conclusion: PS is more effective for TURP anesthesia and has a better protective effect on early postoperative cognitive function.
Keywords: anesthetic effect, cognitive function, propofol, sufentanil, transurethral resection of the prostate, fentanyl
1Department of Anesthesiology and Surgery, First People’s Hospital of Yongkang City, Yongkang City, Zhejiang Province, 321300, People’s Republic of China; 2Department of Medical Oncology, First People’s Hospital of Yongkang City, Yongkang City, Zhejiang Province, 321300, People’s Republic of China
Correspondence: Tong Dong, Department of Anesthesiology and Surgery, First People’s Hospital of Yongkang City, No. 599 Jinshan West Road, Yongkang City, Zhejiang Province, 321300, People’s Republic of China, Email 15867932663@163.com
Objective: The aim of this study is to compare the anesthetic effect and cognitive function impact of propofol-sufentanil (PS) versus propofol-fentanyl (PF) in elderly patients undergoing transurethral resection of the prostate (TURP) under general anesthesia (GA).
Methods: This is a retrospective cohort study conducted in First People’s Hospital of Yongkang City. They included 98 patients aged 65 and above who underwent TURP under GA between October 2023 and March 2025. 49 patients who received PS were matched with a cohort of propofol-fentanyl (PF) in a 1:1 ratio. Compare the hemodynamic parameters (heart rate (HR) and mean arterial pressure (MAP)) of two groups at 30 minutes before anesthesia induction (T0), after anesthesia completion (T1), at the time of skin incision (T2), at the end of surgery (T3), at the postanesthesia care unit (PACU) (T4), 15 minutes after PACU arrival (T5), and 30 minutes after PACU arrival (T6). Compare two perioperative indicators (anesthesia onset time, postoperative awakening time, and extubation time). Compare the pain visual analogue scale (VAS) scores of two groups at three, 12, and 24 hours after surgery. And the Montreal Cognitive Assessment Scale (MoCA) was used to evaluate the number of patients with cognitive impairment at six, 24, and 72 hours after surgery in two groups. Compare the incidence of adverse reactions within 72 hours after surgery between two groups.
Results: Compared with the PF group, the PS group had more stable hemodynamics during T2-T5 (P< 0.05); VAS scores were lower at 12 and 24 hours postoperatively (P< 0.05); The anesthesia onset time, postoperative awakening time, and extubation time of the PS group were significantly shorter than those of the PF group (P< 0.05); The incidence of cognitive dysfunction was lower at six and 24 hours after surgery (P< 0.05). However, there was no significant difference in the incidence of various complications between the two groups (P> 0.05).
Conclusion: PS is more effective for TURP anesthesia and has a better protective effect on early postoperative cognitive function.
Keywords: anesthetic effect, cognitive function, propofol, sufentanil, transurethral resection of the prostate, fentanyl