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已发表论文
脓毒症相关骨骼肌萎缩的综合评述：机制、诊断及治疗策略
Authors Wu Q, Huang Q, Xu Z, Hou C, Wang C
Received 19 July 2025
Accepted for publication 11 December 2025
Published 21 December 2025 Volume 2025:18 Pages 17879—17894
DOI https://doi.org/10.2147/JIR.S554850
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Ning Quan
Qiqi Wu,1,* Qiufen Huang,2,* Zhikai Xu,1 Chaoyao Hou,1 Chuntao Wang1
1Trauma Center/Department of Emergency and Traumatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2Department of Neurosurgery, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, 437000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Chuntao Wang, Email 1241947226@qq.com
Abstract: This comprehensive review aims to synthesize current evidence on sepsis-related skeletal muscle atrophy, with a focus on underlying mechanisms, diagnostic approaches, and therapeutic interventions. A systematic literature search was conducted in PubMed, Web of Science, and Cochrane Library up to October 2024, including clinical, translational, and animal studies. We critically analyzed the pathophysiological mechanisms linking sepsis to muscle wasting, including inflammatory signaling, mitochondrial dysfunction, and proteolytic pathways. Epidemiological data indicate a high incidence of muscle atrophy in sepsis patients, particularly among the elderly and those with comorbidities. Diagnostic modalities such as CT, MRI, ultrasound, and emerging biomarkers including urinary titin and myokines are discussed. Treatment strategies encompassing nutritional support, pharmacotherapy (eg, GLP-1RAs, myostatin inhibitors), and rehabilitation are evaluated. Controversies regarding etiology and treatment efficacy are highlighted. Future directions include the exploration of novel biomarkers, genomics-based personalized therapy, and long-term outcome studies. This review provides a structured and critical appraisal of the current state of knowledge, aiming to inform clinical practice and future research.
Keywords: skeletal muscle atrophy, sepsis, inflammatory cytokines, mechanism, nutrition
1Trauma Center/Department of Emergency and Traumatic Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2Department of Neurosurgery, Xianning Central Hospital, The First Affiliated Hospital of Hubei University of Science and Technology, Xianning, 437000, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Chuntao Wang, Email 1241947226@qq.com
Abstract: This comprehensive review aims to synthesize current evidence on sepsis-related skeletal muscle atrophy, with a focus on underlying mechanisms, diagnostic approaches, and therapeutic interventions. A systematic literature search was conducted in PubMed, Web of Science, and Cochrane Library up to October 2024, including clinical, translational, and animal studies. We critically analyzed the pathophysiological mechanisms linking sepsis to muscle wasting, including inflammatory signaling, mitochondrial dysfunction, and proteolytic pathways. Epidemiological data indicate a high incidence of muscle atrophy in sepsis patients, particularly among the elderly and those with comorbidities. Diagnostic modalities such as CT, MRI, ultrasound, and emerging biomarkers including urinary titin and myokines are discussed. Treatment strategies encompassing nutritional support, pharmacotherapy (eg, GLP-1RAs, myostatin inhibitors), and rehabilitation are evaluated. Controversies regarding etiology and treatment efficacy are highlighted. Future directions include the exploration of novel biomarkers, genomics-based personalized therapy, and long-term outcome studies. This review provides a structured and critical appraisal of the current state of knowledge, aiming to inform clinical practice and future research.
Keywords: skeletal muscle atrophy, sepsis, inflammatory cytokines, mechanism, nutrition