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已发表论文
基于 ImmunoCAP 的福州地区儿童呼吸道过敏症临床管理及预防的吸入性特异性 IgE 检测特征：一项横断面队列研究
Authors Li Y, Lin C, Wang Q, Zhang L, Zhu Z, Cheng F, Wang B
Received 23 July 2025
Accepted for publication 12 December 2025
Published 21 December 2025 Volume 2025:18 Pages 1847—1856
DOI https://doi.org/10.2147/JAA.S549970
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Luis Garcia-Marcos
Yadong Li,1,* Chenye Lin,2,* Qianyun Wang,3,* Li Zhang,4 Zhirong Zhu,5 Feng Cheng,1 Bin Wang1
1Department of Clinical Laboratory, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Department of Respiratory, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 3Department of Clinical Laboratory, Wu Mengchao Memorial Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 4Department of Laboratory Medicine, the School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 5Information Center, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Feng Cheng, Department of Clinical laboratory, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350000, People’s Republic of China, Email FCheng18700@163.com Bin Wang, Department of Clinical laboratory, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350000, People’s Republic of China, Email 892641803@qq.com
Rational: The incidence of pediatric respiratory allergic diseases is rising annually. However, no study has systematically investigated the spectrum of inhalant allergens in children from Fuzhou, China, using ImmunoCAP assay technology and cohort analysis. This study aimed to characterize the distribution of allergen-specific IgE (sIgE) in children aged 0– 14 years with respiratory allergies in Fuzhou, providing theoretical support for etiological diagnosis, treatment, and prevention.
Methods: A total of 196 children underwent allergen screening: 116 diagnosed with allergic rhinitis (AR) and 80 with asthma (AS). Serum sIgE antibodies against inhalant allergens were detected using the ImmunoCAP system.
Results: In the AR group, Dermatophagoides pteronyssinus (d1) showed the highest sensitization rate (112/116), followed by Dermatophagoides farinae (d2) (110/116). In the AS group, d1 and d2 had equally high positivity rates (both 78/80), while Blattella germanica (i6) sensitization was significantly higher in AS than in AR. Sensitization to the animal epithelium panel (ex1) differed significantly between diseases in the 4-6-year age group. Correlation analysis revealed a strong positive correlation between tree pollen mix (tx5) and weed pollen mix (wx5) in both groups, and a significant correlation between d2 and d1.
Conclusion: Dermatophagoides pteronyssinus (d1) and D. farinae (d2) are the predominant allergens in pediatric respiratory allergies in Fuzhou. This study offers valuable insights for preventing and treating these conditions.
Keywords: respiratory allergic diseases, children, specific IgE, Immuno-CAP system
1Department of Clinical Laboratory, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Department of Respiratory, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 3Department of Clinical Laboratory, Wu Mengchao Memorial Hospital of Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 4Department of Laboratory Medicine, the School of Medical Technology and Engineering, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 5Information Center, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Feng Cheng, Department of Clinical laboratory, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350000, People’s Republic of China, Email FCheng18700@163.com Bin Wang, Department of Clinical laboratory, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, 350000, People’s Republic of China, Email 892641803@qq.com
Rational: The incidence of pediatric respiratory allergic diseases is rising annually. However, no study has systematically investigated the spectrum of inhalant allergens in children from Fuzhou, China, using ImmunoCAP assay technology and cohort analysis. This study aimed to characterize the distribution of allergen-specific IgE (sIgE) in children aged 0– 14 years with respiratory allergies in Fuzhou, providing theoretical support for etiological diagnosis, treatment, and prevention.
Methods: A total of 196 children underwent allergen screening: 116 diagnosed with allergic rhinitis (AR) and 80 with asthma (AS). Serum sIgE antibodies against inhalant allergens were detected using the ImmunoCAP system.
Results: In the AR group, Dermatophagoides pteronyssinus (d1) showed the highest sensitization rate (112/116), followed by Dermatophagoides farinae (d2) (110/116). In the AS group, d1 and d2 had equally high positivity rates (both 78/80), while Blattella germanica (i6) sensitization was significantly higher in AS than in AR. Sensitization to the animal epithelium panel (ex1) differed significantly between diseases in the 4-6-year age group. Correlation analysis revealed a strong positive correlation between tree pollen mix (tx5) and weed pollen mix (wx5) in both groups, and a significant correlation between d2 and d1.
Conclusion: Dermatophagoides pteronyssinus (d1) and D. farinae (d2) are the predominant allergens in pediatric respiratory allergies in Fuzhou. This study offers valuable insights for preventing and treating these conditions.
Keywords: respiratory allergic diseases, children, specific IgE, Immuno-CAP system