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已发表论文
2 型糖尿病患者单核细胞与高密度脂蛋白胆固醇比值与内脏型肥胖的关系：一项横断面研究
Authors Hu Y , Zheng J, Xing Y, Song Y, Wu X
Received 1 October 2025
Accepted for publication 28 November 2025
Published 22 December 2025 Volume 2025:18 Pages 4755—4765
DOI https://doi.org/10.2147/DMSO.S518916
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Rebecca Baqiyyah Conway
Ye Hu,1 Jia Zheng,2 Yubo Xing,1 Yingxiang Song,1 Xiaohong Wu1
1Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, 310014, People’s Republic of China; 2Center for General Practice Medicine, Department of Nutrition, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, 310014, People’s Republic of China
Correspondence: Xiaohong Wu, Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, 310014, People’s Republic of China, Tel/Fax +86-579-85893937, Email drxhwu@163.com
Purpose: The study aimed to explore the relationship between the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and visceral fat area (VFA) in patients with type 2 diabetes mellitus (T2DM).
Patients and Methods: A total of 2156 patients with T2DM who received medical treatment at Zhejiang Provincial People’s Hospital participated in this study. Patients were categorized into two groups based on VFA: the increased VFA group (VFA ≥ 100 cm2, n = 1091) and the normal VFA group (VFA < 100 cm2, n = 1065). Biochemical indicators were measured via blood tests, whereas VFA was measured using bioelectrical impedance analysis. Spearman correlation and linear regression analysis were conducted to examine the association between MHR and VFA. Receiver operating characteristic (ROC) curves for predicting the VFA were constructed, and areas under the ROC curves were estimated.
Results: MHR level was significantly higher in the increased VFA group (p < 0.001) than in the normal VFA group. Spearman correlation analysis showed a positive association between VFA and MHR (r = 0.366, p < 0.001). Multivariate linear regression analysis revealed that elevated MHR is an independent factor for increased VFA (β = 20.64, 95% CI 13.46– 27.82, p < 0.001). After stratification by hemoglobin A1c levels and diabetes duration, MHR remained independently associated with VFA. ROC analysis indicated that MHR has a predictive effect on VFA, with an area under the curve of 0.708 (specificity = 58%, sensitivity = 73%).
Conclusion: MHR levels are associated with visceral fat area in patients with T2DM, which has a modest predictive value, and it may be useful in detecting visceral obesity.
Keywords: visceral fat area, monocyte-to-high-density lipoprotein cholesterol ratio, type 2 diabetes mellitus, abdominal fat distribution
1Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, 310014, People’s Republic of China; 2Center for General Practice Medicine, Department of Nutrition, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, 310014, People’s Republic of China
Correspondence: Xiaohong Wu, Geriatric Medicine Center, Department of Endocrinology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, 310014, People’s Republic of China, Tel/Fax +86-579-85893937, Email drxhwu@163.com
Purpose: The study aimed to explore the relationship between the monocyte-to-high-density lipoprotein cholesterol ratio (MHR) and visceral fat area (VFA) in patients with type 2 diabetes mellitus (T2DM).
Patients and Methods: A total of 2156 patients with T2DM who received medical treatment at Zhejiang Provincial People’s Hospital participated in this study. Patients were categorized into two groups based on VFA: the increased VFA group (VFA ≥ 100 cm2, n = 1091) and the normal VFA group (VFA < 100 cm2, n = 1065). Biochemical indicators were measured via blood tests, whereas VFA was measured using bioelectrical impedance analysis. Spearman correlation and linear regression analysis were conducted to examine the association between MHR and VFA. Receiver operating characteristic (ROC) curves for predicting the VFA were constructed, and areas under the ROC curves were estimated.
Results: MHR level was significantly higher in the increased VFA group (p < 0.001) than in the normal VFA group. Spearman correlation analysis showed a positive association between VFA and MHR (r = 0.366, p < 0.001). Multivariate linear regression analysis revealed that elevated MHR is an independent factor for increased VFA (β = 20.64, 95% CI 13.46– 27.82, p < 0.001). After stratification by hemoglobin A1c levels and diabetes duration, MHR remained independently associated with VFA. ROC analysis indicated that MHR has a predictive effect on VFA, with an area under the curve of 0.708 (specificity = 58%, sensitivity = 73%).
Conclusion: MHR levels are associated with visceral fat area in patients with T2DM, which has a modest predictive value, and it may be useful in detecting visceral obesity.
Keywords: visceral fat area, monocyte-to-high-density lipoprotein cholesterol ratio, type 2 diabetes mellitus, abdominal fat distribution