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已发表论文
癌症疼痛中右半球神经元功能障碍：一项静息态功能磁共振成像探索性研究
Authors Xu D , Liu Z, Wu Z, Zhang Y, He Y
Received 17 August 2025
Accepted for publication 6 December 2025
Published 22 December 2025 Volume 2025:18 Pages 6993—7003
DOI https://doi.org/10.2147/JPR.S553431
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Amitabh Gulati
Danghan Xu,1,* Zhaoxi Liu,2,* Zexia Wu,3 Yue Zhang,3 Yihan He3
1Huazhou Street Community Health Service Center, Haizhu District, Guangzhou, Guangzhou, 510405, People’s Republic of China; 2The Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University, Guangzhou, 510120, People’s Republic of China; 3The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yihan He, Email yihanhe@gzucm.edu.cn
Background: This exploratory study investigated the neurobiological mechanisms of cancer pain by examining functional brain alterations using resting-state functional magnetic resonance imaging (fMRI), aiming to characterize neural network changes and identify potential neuroimaging biomarkers.
Methods: A cross-sectional study was conducted from October 2021 to October 2022, involving 20 cancer pain patients and 20 age-, sex-, and education-matched healthy controls. Participants underwent comprehensive clinical assessments and 3.0T resting-state fMRI scanning. Inclusion criteria were patients aged ≥ 18 years with pathologically confirmed malignant neoplasms experiencing moderate to severe pain (NRS ≥ 4). Functional connectivity and low-frequency amplitude analyses were performed using the right nucleus accumbens as a seed region.
Results: Significant neuroplastic changes were observed in cancer pain patients, primarily in the right hemisphere. Low-frequency amplitude analysis revealed reduced spontaneous neural activity in critical brain regions, including the right medial prefrontal cortex (T = − 4.36), right superior/middle frontal gyrus (T = − 5.21), and right precuneus (T = − 4.15). Functional connectivity analysis showed substantially decreased connectivity between the right nucleus accumbens and bilateral medial prefrontal cortex (T = − 4.86), left temporal pole (T = − 5.62), and right superior temporal gyrus (T = − 5.05).
Conclusion: The study provides preliminary evidence of right hemispheric neuronal dysfunction in cancer pain, highlighting altered functional connectivity in emotion regulation and pain processing neural circuits. These findings offer insights into the neurobiological mechanisms of cancer pain and potential objective assessment approaches.
Keywords: fMRI, negative emotion, cancer pain, cross-sectional study
1Huazhou Street Community Health Service Center, Haizhu District, Guangzhou, Guangzhou, 510405, People’s Republic of China; 2The Affiliated Traditional Chinese Medicine Hospital of Guangzhou Medical University, Guangzhou, 510120, People’s Republic of China; 3The Second Affiliated Hospital of Guangzhou University of Traditional Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yihan He, Email yihanhe@gzucm.edu.cn
Background: This exploratory study investigated the neurobiological mechanisms of cancer pain by examining functional brain alterations using resting-state functional magnetic resonance imaging (fMRI), aiming to characterize neural network changes and identify potential neuroimaging biomarkers.
Methods: A cross-sectional study was conducted from October 2021 to October 2022, involving 20 cancer pain patients and 20 age-, sex-, and education-matched healthy controls. Participants underwent comprehensive clinical assessments and 3.0T resting-state fMRI scanning. Inclusion criteria were patients aged ≥ 18 years with pathologically confirmed malignant neoplasms experiencing moderate to severe pain (NRS ≥ 4). Functional connectivity and low-frequency amplitude analyses were performed using the right nucleus accumbens as a seed region.
Results: Significant neuroplastic changes were observed in cancer pain patients, primarily in the right hemisphere. Low-frequency amplitude analysis revealed reduced spontaneous neural activity in critical brain regions, including the right medial prefrontal cortex (T = − 4.36), right superior/middle frontal gyrus (T = − 5.21), and right precuneus (T = − 4.15). Functional connectivity analysis showed substantially decreased connectivity between the right nucleus accumbens and bilateral medial prefrontal cortex (T = − 4.86), left temporal pole (T = − 5.62), and right superior temporal gyrus (T = − 5.05).
Conclusion: The study provides preliminary evidence of right hemispheric neuronal dysfunction in cancer pain, highlighting altered functional connectivity in emotion regulation and pain processing neural circuits. These findings offer insights into the neurobiological mechanisms of cancer pain and potential objective assessment approaches.
Keywords: fMRI, negative emotion, cancer pain, cross-sectional study