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已发表论文
针刺治疗过敏性疾病的综述：通过抑制炎症通路和平衡细胞因子来调节肥大细胞功能
Authors Li Y, Meng Y, Chen C, Jiang K, Li J
Received 8 November 2025
Accepted for publication 13 December 2025
Published 22 December 2025 Volume 2025:18 Pages 7739—7754
DOI https://doi.org/10.2147/IJGM.S579576
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Woon-Man Kung
Yuan Li,1,* Ying Meng,2,* Chen Chen,3 Kexin Jiang,4 Ji Li1
1School of Basic Medical Science, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China; 2Personnel Department, Beidahuang Group General Hospital, Harbin, Heilongjiang, 150036, People’s Republic of China; 3Department of the Ward 5 of Acupuncture and Moxibustion, The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China; 4Graduate School, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ji Li, School of Basic Medical Science, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China, Email j1906956088@163.com
Objective: Mast cells drive allergic diseases (asthma, rhinitis, dermatitis) via degranulation and pro-inflammatory mediator release. This review explores acupuncture’s role in modulating mast cells to alleviate allergic symptoms.
Methods: We screened PubMed and Embase databases from January 2010 to January 2025 to search for published studies. The search keywords used are as follows: [“acupuncture” or “electroacupuncture”], [“allergic disease” or “asthma” or “allergic rhinitis” or “dermatitis” or “urticaria”], [“mast cell”]. 365 peer-reviewed studies on human/animal models were included, and articles that did not meet the requirements were excluded.
Results: Acupuncture inhibited mast cell degranulation, reducing histamine and IgE levels. It downregulated pro-inflammatory cytokines (TNF-α, IL-4, IL-5, IL-13) and upregulated anti-inflammatory IL-10, via suppressing NF-κB, MAPK (p38, ERK), and TLR4/MyD88 pathways. Clinically, it improved asthma (FEV1/PEF elevation), allergic rhinitis, and atopic dermatitis. Preclinically, it reduced eosinophil infiltration and inhibited NLRP3/caspase-1-mediated pyroptosis, further mitigating inflammation.
Conclusion: Acupuncture alleviates allergic disorders by targeting mast cells and inflammatory cascades, supporting its potential as a safe, effective therapeutic option.
Keywords: acupuncture, mast cells, allergic diseases, allergic asthma, traditional Chinese medicine, immune system
1School of Basic Medical Science, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China; 2Personnel Department, Beidahuang Group General Hospital, Harbin, Heilongjiang, 150036, People’s Republic of China; 3Department of the Ward 5 of Acupuncture and Moxibustion, The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China; 4Graduate School, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Ji Li, School of Basic Medical Science, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China, Email j1906956088@163.com
Objective: Mast cells drive allergic diseases (asthma, rhinitis, dermatitis) via degranulation and pro-inflammatory mediator release. This review explores acupuncture’s role in modulating mast cells to alleviate allergic symptoms.
Methods: We screened PubMed and Embase databases from January 2010 to January 2025 to search for published studies. The search keywords used are as follows: [“acupuncture” or “electroacupuncture”], [“allergic disease” or “asthma” or “allergic rhinitis” or “dermatitis” or “urticaria”], [“mast cell”]. 365 peer-reviewed studies on human/animal models were included, and articles that did not meet the requirements were excluded.
Results: Acupuncture inhibited mast cell degranulation, reducing histamine and IgE levels. It downregulated pro-inflammatory cytokines (TNF-α, IL-4, IL-5, IL-13) and upregulated anti-inflammatory IL-10, via suppressing NF-κB, MAPK (p38, ERK), and TLR4/MyD88 pathways. Clinically, it improved asthma (FEV1/PEF elevation), allergic rhinitis, and atopic dermatitis. Preclinically, it reduced eosinophil infiltration and inhibited NLRP3/caspase-1-mediated pyroptosis, further mitigating inflammation.
Conclusion: Acupuncture alleviates allergic disorders by targeting mast cells and inflammatory cascades, supporting its potential as a safe, effective therapeutic option.
Keywords: acupuncture, mast cells, allergic diseases, allergic asthma, traditional Chinese medicine, immune system