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已发表论文
急性不可逆性牙髓炎单次就诊根管治疗中 Vitapex 糊剂的短期疗效：一项回顾性队列研究
Authors Liu J, Li F, Liang X, Niu J
Received 15 September 2025
Accepted for publication 11 December 2025
Published 23 December 2025 Volume 2025:18 Pages 7043—7052
DOI https://doi.org/10.2147/JPR.S563507
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr David Keith
Jia Liu,1 Fangfei Li,2 Xiaolong Liang,1 Jiahui Niu1
1Department of Stomatology, Shijiazhuang Second Hospital, Shijiazhuang, 050000, People’s Republic of China; 2The Second Outpatient Department of the Provincial Organs of Hebei Province, Shijiazhuang, 050000, People’s Republic of China
Correspondence: Jia Liu, Email llxkqk1@163.com
Background: The selection of root canal obturation material is critical for the successful management of acute irreversible pulpitis. Vitapex, an iodoform-calcium hydroxide-based paste, possesses recognized antimicrobial and biocompatible properties. However, comprehensive evidence comparing its efficacy in single-visit root canal treatment against the conventional gutta-percha/zinc oxide-eugenol (ZOE) sealer combination remains relatively limited.
Objective: To compare the clinical efficacy of Vitapex paste versus gutta-percha/ZOE sealer in single-visit root canal treatment for acute irreversible pulpitis.
Methods: In this single-center retrospective cohort study, clinical data from 112 patients with acute irreversible pulpitis who underwent single-visit root canal therapy between April 2022 and August 2024 were analyzed. Patients were allocated into two groups based on the obturation material: the Vitapex group (n=56), obturated with Vitapex paste, and the gutta-percha/ZOE group (n=56), obturated using the cold lateral compaction technique with gutta-percha points and ZOE sealer. Key outcome measures included time to pain relief, time to swelling resolution, time to return to normal masticatory function, Visual Analogue Scale (VAS) scores, bite force, chewing efficiency, levels of inflammatory factors (hs-CRP, IL-6, TNF-α), periodontal health indices (Bleeding Index-BI, Plaque Index-PLI, Probing Depth-PD), and the incidence of adverse reactions.
Results: The Vitapex group showed significantly shorter recovery times for pain relief, swelling resolution, and return to normal function (all P< 0.001), significantly lower VAS scores at 1 and 4 weeks (P< 0.05), and greater improvements in masticatory function at 4 weeks (P< 0.05). Inflammatory markers and periodontal health indices improved more significantly with Vitapex (all P< 0.001). The adverse reaction rate was lower with Vitapex (5.4% vs 12.5%), though not statistically significant (P=0.325).
Conclusion: Vitapex demonstrates superior outcomes in single-visit treatment for irreversible pulpitis, offering faster recovery, better pain control, improved function, and reduced inflammation compared to gutta-percha/ZOE, making it a valuable clinical alternative.
Keywords: irreversible pulpitis, vitapex, root canal treatment, pain, masticatory function, inflammatory mediators, periodontal health
1Department of Stomatology, Shijiazhuang Second Hospital, Shijiazhuang, 050000, People’s Republic of China; 2The Second Outpatient Department of the Provincial Organs of Hebei Province, Shijiazhuang, 050000, People’s Republic of China
Correspondence: Jia Liu, Email llxkqk1@163.com
Background: The selection of root canal obturation material is critical for the successful management of acute irreversible pulpitis. Vitapex, an iodoform-calcium hydroxide-based paste, possesses recognized antimicrobial and biocompatible properties. However, comprehensive evidence comparing its efficacy in single-visit root canal treatment against the conventional gutta-percha/zinc oxide-eugenol (ZOE) sealer combination remains relatively limited.
Objective: To compare the clinical efficacy of Vitapex paste versus gutta-percha/ZOE sealer in single-visit root canal treatment for acute irreversible pulpitis.
Methods: In this single-center retrospective cohort study, clinical data from 112 patients with acute irreversible pulpitis who underwent single-visit root canal therapy between April 2022 and August 2024 were analyzed. Patients were allocated into two groups based on the obturation material: the Vitapex group (n=56), obturated with Vitapex paste, and the gutta-percha/ZOE group (n=56), obturated using the cold lateral compaction technique with gutta-percha points and ZOE sealer. Key outcome measures included time to pain relief, time to swelling resolution, time to return to normal masticatory function, Visual Analogue Scale (VAS) scores, bite force, chewing efficiency, levels of inflammatory factors (hs-CRP, IL-6, TNF-α), periodontal health indices (Bleeding Index-BI, Plaque Index-PLI, Probing Depth-PD), and the incidence of adverse reactions.
Results: The Vitapex group showed significantly shorter recovery times for pain relief, swelling resolution, and return to normal function (all P< 0.001), significantly lower VAS scores at 1 and 4 weeks (P< 0.05), and greater improvements in masticatory function at 4 weeks (P< 0.05). Inflammatory markers and periodontal health indices improved more significantly with Vitapex (all P< 0.001). The adverse reaction rate was lower with Vitapex (5.4% vs 12.5%), though not statistically significant (P=0.325).
Conclusion: Vitapex demonstrates superior outcomes in single-visit treatment for irreversible pulpitis, offering faster recovery, better pain control, improved function, and reduced inflammation compared to gutta-percha/ZOE, making it a valuable clinical alternative.
Keywords: irreversible pulpitis, vitapex, root canal treatment, pain, masticatory function, inflammatory mediators, periodontal health