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已发表论文
心血管疾病患者进行短期高强度间歇训练和中等强度间歇训练后心率恢复的可比性改善
Authors Song Q, Chang J, Bai B, Abudoukelimu M, Jiang Z, Zhu J, Lin Z, Guo J, Ma H , Hu D
Received 29 August 2025
Accepted for publication 8 December 2025
Published 23 December 2025 Volume 2025:18 Pages 8185—8196
DOI https://doi.org/10.2147/JMDH.S560641
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Charles V Pollack
Qianqian Song,1,2,* Jinna Chang,3,* Bingqing Bai,1 Mayila Abudoukelimu,1 Zhongxing Jiang,1 Junshuo Zhu,4 Zhaoqin Lin,1 Jianjun Guo,2 Huan Ma,1 Dayi Hu2,5
1Department of Cardiac Rehabilitation, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China; 2Center for Sports-Medicine Integrative Innovation, Capital University of Physical Education and Sports, Beijing, People’s Republic of China; 3Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People’s Republic of China; 4School of Medicine South China University of Technology, Guangdong, People’s Republic of China; 5Institute of Cardiovascular Diseases, Peking University People’s Hospital, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Dayi Hu, Center for Sports-Medicine Integrative Innovation, Capital University of Physical Education and Sports, Beijing, China; Institute of Cardiovascular Diseases, Peking University People’s Hospital, Beijing, People’s Republic of China, Email 23008006028@cupes.edu.cn Huan Ma, Department of Cardiac rehabilitation, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China, Email mahuandoctor@163.com
Objective: Heart rate recovery (HRR) is a validated prognostic marker in cardiovascular disease (CVD). This study evaluated and compared the effects of 4-week high-intensity interval training (HIIT) and moderate-intensity interval training (MIIT) on post-exercise HRR in patients with CVD.
Methods: A total of 1,020 CVD patients undergoing cardiac rehabilitation (Jan 2021-May 2024) were screened, and 209 who completed 12 sessions and cardiopulmonary exercise tests were included (HIIT: 82; MIIT: 127). The mean ages were 55.2 (HIIT) and 52.9 years (MIIT), with females comprising 34.1% and 34.6%, respectively. The MIIT protocol included four 8-min cycling bouts (RPE 12– 14) with 2-min active recovery, while HIIT involved 20– 25 × 30-s high-intensity bouts (RPE 14– 15) alternating with 30-s low-intensity recovery.
Results: Both interventions significantly improved HRR (HIIT: 3.1± 8.7 bpm, P = 0.002; MIIT: 3.0± 10.0 bpm, P = 0.001), with no between-group difference (P = 0.816). Peak VO2 similarly increased in both groups (HIIT: 3.3± 2.8; MIIT: 3.0± 3.6 mL·kg− 1·min− 1; P < 0.001). Other related measures were also notably improved (P < 0.05). Multivariable regression analysis revealed that the change in HRR was inversely associated with the change in resting heart rate in both HIIT (β = − 0.227, P = 0.04) and MIIT (β = − 0.318, P < 0.001) cohorts.
Conclusion: Both short-term HIIT and MIIT comparably enhance HRR in patients with CVD, highlighting the clinical applicability of interval training as an efficient option for patients with limited time availability. However, the retrospective design limits causal inference and requires confirmation in future studies.
Keywords: cardiovascular disease, high-intensity interval training, moderate-intensity interval training, heart rate recovery
1Department of Cardiac Rehabilitation, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China; 2Center for Sports-Medicine Integrative Innovation, Capital University of Physical Education and Sports, Beijing, People’s Republic of China; 3Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, People’s Republic of China; 4School of Medicine South China University of Technology, Guangdong, People’s Republic of China; 5Institute of Cardiovascular Diseases, Peking University People’s Hospital, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Dayi Hu, Center for Sports-Medicine Integrative Innovation, Capital University of Physical Education and Sports, Beijing, China; Institute of Cardiovascular Diseases, Peking University People’s Hospital, Beijing, People’s Republic of China, Email 23008006028@cupes.edu.cn Huan Ma, Department of Cardiac rehabilitation, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of China, Email mahuandoctor@163.com
Objective: Heart rate recovery (HRR) is a validated prognostic marker in cardiovascular disease (CVD). This study evaluated and compared the effects of 4-week high-intensity interval training (HIIT) and moderate-intensity interval training (MIIT) on post-exercise HRR in patients with CVD.
Methods: A total of 1,020 CVD patients undergoing cardiac rehabilitation (Jan 2021-May 2024) were screened, and 209 who completed 12 sessions and cardiopulmonary exercise tests were included (HIIT: 82; MIIT: 127). The mean ages were 55.2 (HIIT) and 52.9 years (MIIT), with females comprising 34.1% and 34.6%, respectively. The MIIT protocol included four 8-min cycling bouts (RPE 12– 14) with 2-min active recovery, while HIIT involved 20– 25 × 30-s high-intensity bouts (RPE 14– 15) alternating with 30-s low-intensity recovery.
Results: Both interventions significantly improved HRR (HIIT: 3.1± 8.7 bpm, P = 0.002; MIIT: 3.0± 10.0 bpm, P = 0.001), with no between-group difference (P = 0.816). Peak VO2 similarly increased in both groups (HIIT: 3.3± 2.8; MIIT: 3.0± 3.6 mL·kg− 1·min− 1; P < 0.001). Other related measures were also notably improved (P < 0.05). Multivariable regression analysis revealed that the change in HRR was inversely associated with the change in resting heart rate in both HIIT (β = − 0.227, P = 0.04) and MIIT (β = − 0.318, P < 0.001) cohorts.
Conclusion: Both short-term HIIT and MIIT comparably enhance HRR in patients with CVD, highlighting the clinical applicability of interval training as an efficient option for patients with limited time availability. However, the retrospective design limits causal inference and requires confirmation in future studies.
Keywords: cardiovascular disease, high-intensity interval training, moderate-intensity interval training, heart rate recovery