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已发表论文
针刺敏感穴位与假针刺治疗颈型颈椎病：一项随机对照试验的研究方案
Authors Li C, Wang J, Shao X, Wu Y , Qu X, Cai J, He L, Yu L, Xu R, Xia Y, Wang R, Zhang L, Qiu Y
Received 19 June 2025
Accepted for publication 18 November 2025
Published 23 December 2025 Volume 2025:18 Pages 6963—6976
DOI https://doi.org/10.2147/JPR.S548317
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Houman Danesh
Chaoran Li,1– 3,* Junyi Wang,2,* Xiaomei Shao,1 Yuanyuan Wu,2,3 Xinyuan Qu,2 Jin Cai,4 Lilan He,5 Liqing Yu,4 Ruocheng Xu,2 Yixiang Xia,2 Ruoyu Wang,6 Lanlan Zhang,7 Yunjing Qiu8
1Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province), Hangzhou, People’s Republic of China; 2The Third School of Clinical Medicine (School of Rehabilitation Medicine), Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 3Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 4Department of Ultrasound, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province), Hangzhou, People’s Republic of China; 5Department of Ultrasound, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, People’s Republic of China; 6The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 7Department of nursing, Hangzhou Fuyang Sunshine Geriatric Hospital, Hangzhou, People’s Republic of China; 8School of Nursing and Midwifery, Faculty of Health, University of Technology Sydney, Sydney, Australia
*These authors contributed equally to this work
Correspondence: Xiaomei Shao, Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province), Hangzhou, People’s Republic of China, Email 13185097375@163.com
Purpose: Neck-type cervical spondylosis (NTCS) is the most common subtype of cervical spondylosis. Acupuncture is frequently employed in the clinical management of NTCS. According to the traditional Chinese medicine theory of acupoint sensitization, acupoints represent both highly sensitive reactive sites during pathological states and the principal loci for therapeutic stimulation via acupuncture. Stimulating strongly sensitive points has been shown to be effective in treating disease and may enhance clinical efficacy. This study aims to investigate the clinical effect and safety of acupuncture at sensitized acupoints (SA) in alleviating symptoms in patients with NTCS, based on the specificity of acupoint sensitization.
Patients and Methods: This is a single-center, prospective, patient- and assessor-blinded, randomized, sham-controlled trial involving patients diagnosed with NTCS. Participants will be randomly assigned in a 1:1 ratio to two groups: the SA group and sham acupuncture (SHA) group. All participants will be treated with acupuncture three times during the first week, followed by a subsequent assessment scheduled in week five. The primary outcome is the alteration in the intensity of neck pain, assessed with the visual analogue scale. Secondary outcomes include changes in the neck disability index, range of motion, the 12-item short form health survey, cervical musculoskeletal ultrasound findings, and pressure pain threshold values. The intention-to-treat analysis will be applied for statistics.
Conclusion: This trial will be the first randomized controlled trial to investigate the therapeutic efficacy and safety profile of acupuncture SA in the treatment of NTCS. It is also the first trial to combine subjective and objective outcome measures to comprehensively evaluate acupuncture’s curative effect on NTCS management. The findings may provide evidence supporting acupuncture as an effective treatment option for NTCS and offer insights into its underlying biological mechanisms.
Trial Registration: ClinicalTrials.gov (https://clinicaltrials.gov/), identifier: NCT06847945.
Keywords: acupuncture, neck-type cervical spondylosis, sensitized acupoints, study protocol, randomized controlled trial, clinical effect
1Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province), Hangzhou, People’s Republic of China; 2The Third School of Clinical Medicine (School of Rehabilitation Medicine), Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 3Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Department of Neurobiology and Acupuncture Research, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 4Department of Ultrasound, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province), Hangzhou, People’s Republic of China; 5Department of Ultrasound, The Affiliated Dongguan Songshan Lake Central Hospital, Guangdong Medical University, Dongguan, People’s Republic of China; 6The First School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China; 7Department of nursing, Hangzhou Fuyang Sunshine Geriatric Hospital, Hangzhou, People’s Republic of China; 8School of Nursing and Midwifery, Faculty of Health, University of Technology Sydney, Sydney, Australia
*These authors contributed equally to this work
Correspondence: Xiaomei Shao, Department of Acupuncture and Moxibustion, The Third Affiliated Hospital of Zhejiang Chinese Medical University (Zhongshan Hospital of Zhejiang Province), Hangzhou, People’s Republic of China, Email 13185097375@163.com
Purpose: Neck-type cervical spondylosis (NTCS) is the most common subtype of cervical spondylosis. Acupuncture is frequently employed in the clinical management of NTCS. According to the traditional Chinese medicine theory of acupoint sensitization, acupoints represent both highly sensitive reactive sites during pathological states and the principal loci for therapeutic stimulation via acupuncture. Stimulating strongly sensitive points has been shown to be effective in treating disease and may enhance clinical efficacy. This study aims to investigate the clinical effect and safety of acupuncture at sensitized acupoints (SA) in alleviating symptoms in patients with NTCS, based on the specificity of acupoint sensitization.
Patients and Methods: This is a single-center, prospective, patient- and assessor-blinded, randomized, sham-controlled trial involving patients diagnosed with NTCS. Participants will be randomly assigned in a 1:1 ratio to two groups: the SA group and sham acupuncture (SHA) group. All participants will be treated with acupuncture three times during the first week, followed by a subsequent assessment scheduled in week five. The primary outcome is the alteration in the intensity of neck pain, assessed with the visual analogue scale. Secondary outcomes include changes in the neck disability index, range of motion, the 12-item short form health survey, cervical musculoskeletal ultrasound findings, and pressure pain threshold values. The intention-to-treat analysis will be applied for statistics.
Conclusion: This trial will be the first randomized controlled trial to investigate the therapeutic efficacy and safety profile of acupuncture SA in the treatment of NTCS. It is also the first trial to combine subjective and objective outcome measures to comprehensively evaluate acupuncture’s curative effect on NTCS management. The findings may provide evidence supporting acupuncture as an effective treatment option for NTCS and offer insights into its underlying biological mechanisms.
Trial Registration: ClinicalTrials.gov (https://clinicaltrials.gov/), identifier: NCT06847945.
Keywords: acupuncture, neck-type cervical spondylosis, sensitized acupoints, study protocol, randomized controlled trial, clinical effect