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已发表论文
一例暴露于苯扎氯铵的 HIV 感染患者出现颗粒状角化不全：病例报告
Authors Ye L, Li X , Liao B, Fan X, Cheng L , Liu W , Zhang J
Received 13 October 2025
Accepted for publication 18 December 2025
Published 20 December 2025 Volume 2025:18 Pages 3557—3563
DOI https://doi.org/10.2147/CCID.S573908
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Prof. Dr. Rungsima Wanitphakdeedecha
Linyan Ye,1– 5,* Xinze Li,1– 5,* Bei Liao,1– 5,* Xinyi Fan,1– 5 Lifang Cheng,1– 5 Weijun Liu,1– 5 Jing Zhang1– 5
1Department of Dermatology, Dermatology Hospital of Jiangxi Province, Nanchang, Jiangxi, People’s Republic of China; 2Department of Dermatology, Jiangxi Provincial Clinical Research Center for Skin Diseases, Nanchang, Jiangxi, People’s Republic of China; 3Department of Dermatology, Candidate Branch of National Clinical Research Center for Skin Diseases, Nanchang, Jiangxi, People’s Republic of China; 4Department of Dermatology,Dermatology Institute of Jiangxi Province, Nanchang, Jiangxi, People’s Republic of China; 5Department of Dermatology,The Affiliated Dermatology Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jing Zhang; Weijun Liu, Department of Dermatology, Dermatology Hospital of Jiangxi Province, Nanchang, Jiangxi, 330000, People’s Republic of China, Tel +86 19855134654 ; +86 15180151935, Email jzhang_pf@163.com; liuweijun104@163.com
Abstract: Granular parakeratosis (GP) is a rare dermatosis characterized by intertriginous erythematosquamous lesions and parchment-like desquamation, often linked to benzalkonium chloride exposure. We report a 32-year-old male with well-controlled HIV who developed pruritic plaques in the groin and thighs, progressing to pustules and erosions. Diagnosis was confirmed histologically as GP with concurrent Candida albicans infection. The cutaneous lesions resolved completely following an 8-day course of intravenous compound glycyrrhizin (60 mL once daily) combined with cessation of benzalkonium chloride exposure. This article describes the first documented case of HIV-associated GP and details its distinctive clinical features and therapeutic approach.
Keywords: granular parakeratosis, benzalkonium chloride, HIV, Candida albicans
1Department of Dermatology, Dermatology Hospital of Jiangxi Province, Nanchang, Jiangxi, People’s Republic of China; 2Department of Dermatology, Jiangxi Provincial Clinical Research Center for Skin Diseases, Nanchang, Jiangxi, People’s Republic of China; 3Department of Dermatology, Candidate Branch of National Clinical Research Center for Skin Diseases, Nanchang, Jiangxi, People’s Republic of China; 4Department of Dermatology,Dermatology Institute of Jiangxi Province, Nanchang, Jiangxi, People’s Republic of China; 5Department of Dermatology,The Affiliated Dermatology Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jing Zhang; Weijun Liu, Department of Dermatology, Dermatology Hospital of Jiangxi Province, Nanchang, Jiangxi, 330000, People’s Republic of China, Tel +86 19855134654 ; +86 15180151935, Email jzhang_pf@163.com; liuweijun104@163.com
Abstract: Granular parakeratosis (GP) is a rare dermatosis characterized by intertriginous erythematosquamous lesions and parchment-like desquamation, often linked to benzalkonium chloride exposure. We report a 32-year-old male with well-controlled HIV who developed pruritic plaques in the groin and thighs, progressing to pustules and erosions. Diagnosis was confirmed histologically as GP with concurrent Candida albicans infection. The cutaneous lesions resolved completely following an 8-day course of intravenous compound glycyrrhizin (60 mL once daily) combined with cessation of benzalkonium chloride exposure. This article describes the first documented case of HIV-associated GP and details its distinctive clinical features and therapeutic approach.
Keywords: granular parakeratosis, benzalkonium chloride, HIV, Candida albicans