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已发表论文
高甘油三酯血症性急性胰腺炎中的铁死亡：机制及治疗意义
Authors Zou K, Liu W, Xia W, Zhao Y
Received 30 September 2025
Accepted for publication 4 December 2025
Published 24 December 2025 Volume 2025:18 Pages 18115—18135
DOI https://doi.org/10.2147/JIR.S567900
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Nadia Andrea Andreani
Ke Zou,1,2 Wenzhen Liu,3 Wenwen Xia,2 Yan Zhao1,2
1Department of Gastroenterology, Shanghai Tenth People’s Hospital Chongming Branch, Shanghai, 202150, People’s Republic of China; 2Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China; 3Guangzhou University of Chinese Medicine, Guangzhou, 510006, People’s Republic of China
Correspondence: Yan Zhao, Department of Gastroenterology, Shanghai Tenth People’s Hospital of Tongii University, 30L Middle Yanchang Road, Jing’an, Shanghai, 200072, People’s Republic of China, Email zhaoyanwenzhang@163.com
Abstract: Ferroptosis, a iron-dependent programmed cell death characterized by iron-dependent accumulation of lipid peroxidation to lethal levels, is closely related to the pathogenesis of hypertriglyceridemic acute pancreatitis, a condition marked by lipid metabolism disorders. This paper summarizes the latest research progress in understanding the mechanistic contributions on the mechanisms of ferroptosis in HTG-AP, with a particular focus on the roles of lipid peroxidation and iron-catalyzed reactive oxygen species generation in the pathogenesis and progression of HTG-AP. It further elaborates on critical molecules-including the GPX4, ACSL4, SLC7A11 and FSP1-CoQ10-NAD(P)H and key cellular signaling pathways-including the HIF pathways, JAK-STAT pathways, PI3K/ Akt pathways closely linked to ferroptosis in HTG-AP. Understanding the pathophysiological role of hypertriglyceridemia in pancreatic injury is essential for unraveling the complex interplay between lipid and iron metabolic homeostasis. Additionally, by integrating evidence from preclinical models and human studies, this review emphasizes the importance of ferroptosis mechanisms in the treatment of HTG-AP, with the goal of identifying potential therapeutic targets and proposing innovative intervention strategies aimed at mitigating ferroptosis, potentially improving outcomes in HTG-AP.
Keywords: ferroptosis, hypertriglyceridemic acute pancreatitis, lipid peroxidation, therapeutic targets
1Department of Gastroenterology, Shanghai Tenth People’s Hospital Chongming Branch, Shanghai, 202150, People’s Republic of China; 2Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200072, People’s Republic of China; 3Guangzhou University of Chinese Medicine, Guangzhou, 510006, People’s Republic of China
Correspondence: Yan Zhao, Department of Gastroenterology, Shanghai Tenth People’s Hospital of Tongii University, 30L Middle Yanchang Road, Jing’an, Shanghai, 200072, People’s Republic of China, Email zhaoyanwenzhang@163.com
Abstract: Ferroptosis, a iron-dependent programmed cell death characterized by iron-dependent accumulation of lipid peroxidation to lethal levels, is closely related to the pathogenesis of hypertriglyceridemic acute pancreatitis, a condition marked by lipid metabolism disorders. This paper summarizes the latest research progress in understanding the mechanistic contributions on the mechanisms of ferroptosis in HTG-AP, with a particular focus on the roles of lipid peroxidation and iron-catalyzed reactive oxygen species generation in the pathogenesis and progression of HTG-AP. It further elaborates on critical molecules-including the GPX4, ACSL4, SLC7A11 and FSP1-CoQ10-NAD(P)H and key cellular signaling pathways-including the HIF pathways, JAK-STAT pathways, PI3K/ Akt pathways closely linked to ferroptosis in HTG-AP. Understanding the pathophysiological role of hypertriglyceridemia in pancreatic injury is essential for unraveling the complex interplay between lipid and iron metabolic homeostasis. Additionally, by integrating evidence from preclinical models and human studies, this review emphasizes the importance of ferroptosis mechanisms in the treatment of HTG-AP, with the goal of identifying potential therapeutic targets and proposing innovative intervention strategies aimed at mitigating ferroptosis, potentially improving outcomes in HTG-AP.
Keywords: ferroptosis, hypertriglyceridemic acute pancreatitis, lipid peroxidation, therapeutic targets