114027
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
肉碱及其他代谢产物与纤维肌痛：一项孟德尔随机化研究的临床视角
Authors Hong M, Wang J, Huang X, Xu Q, Xiao Y, Ling K
Received 28 September 2025
Accepted for publication 18 December 2025
Published 25 December 2025 Volume 2025:18 Pages 7097—7107
DOI https://doi.org/10.2147/JPR.S569174
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Alaa Abd-Elsayed
Minping Hong,1,* Jianguo Wang,2,* Xiaowen Huang,1 Qin Xu,1 Yujin Xiao,1 Keng Ling2
1Department of Radiology, Jiaxing Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical Universityl, Jiaxing, People’s Republic of China; 2Clinical laboratory, Jiaxing Maternity and Children Health Care Hospital, Jiaxing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Keng Ling, Clinical Laboratory, Jiaxing University, Jiaxing Maternity and Children Health Care Hospital, No. 2468 Zhonghuan East Road, Nanhu District, Jiaxing, Zhejiang Province, 314000, People’s Republic of China, Email 450620239@qq.com Yujin Xiao, Jiaxing Hospital of Traditional Chinese Medical, No. 1501 Zhongshan East Road, Nanhu District, Jiaxing, Zhejiang Province, 314000, People’s Republic of China, Email 249877814@qq.com
Background: Fibromyalgia (FM) is a chronic pain disorder lacking reliable biomarkers. While metabolomic studies have suggested associations with various metabolites, including carnitine, establishing causality remains a challenge. This study integrates clinical metabolomic profiling with a Mendelian Randomization (MR) framework to investigate the potential causal influence of blood metabolites on FM.
Methods: In this study, 96 patients with Fibromyalgia and normal controls were recruited, and the carnitine level in peripheral blood was detected by ELISA method. And then, a two-sample Mendelian randomization (MR) method was used to test the potential causal relationship between 1400 metabolite biomarkers, including the level of carnitine, and Fibromyalgia. Additionally, for those metabolites demonstrating a causal link to Fibromyalgia in the initial MR analysis, a reverse Mendelian Randomization analysis was conducted to further validate these findings.
Results: Carnitine levels were markedly decreased in patients with fibromyalgia compared with healthy controls. The MR analysis identified 10 metabolites potentially causally linked to fibromyalgia. Among them, carnitine has a causal relationship with Fibromyalgia and is a protective factor (OR 0.73, 95% CI: 0.59– 0.91, p = 0.004). There are others, 4 metabolites showed protective effects, whereas 5 were linked to an elevated risk of the condition. The results were consistent among various MR methods, suggesting a strong correlation.
Conclusion: Our findings provide novel evidence supporting a potential causal, protective role of carnitine in FM pathogenesis, alongside other implicated metabolites. These results highlight the promise of metabolic pathways as targets for intervention, but future studies in larger, diverse populations are warranted to confirm these relationships.
Keywords: fibromyalgia, carnitine, metabolomics, Mendelian randomization
1Department of Radiology, Jiaxing Hospital of Traditional Chinese Medicine Affiliated to Zhejiang Chinese Medical Universityl, Jiaxing, People’s Republic of China; 2Clinical laboratory, Jiaxing Maternity and Children Health Care Hospital, Jiaxing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Keng Ling, Clinical Laboratory, Jiaxing University, Jiaxing Maternity and Children Health Care Hospital, No. 2468 Zhonghuan East Road, Nanhu District, Jiaxing, Zhejiang Province, 314000, People’s Republic of China, Email 450620239@qq.com Yujin Xiao, Jiaxing Hospital of Traditional Chinese Medical, No. 1501 Zhongshan East Road, Nanhu District, Jiaxing, Zhejiang Province, 314000, People’s Republic of China, Email 249877814@qq.com
Background: Fibromyalgia (FM) is a chronic pain disorder lacking reliable biomarkers. While metabolomic studies have suggested associations with various metabolites, including carnitine, establishing causality remains a challenge. This study integrates clinical metabolomic profiling with a Mendelian Randomization (MR) framework to investigate the potential causal influence of blood metabolites on FM.
Methods: In this study, 96 patients with Fibromyalgia and normal controls were recruited, and the carnitine level in peripheral blood was detected by ELISA method. And then, a two-sample Mendelian randomization (MR) method was used to test the potential causal relationship between 1400 metabolite biomarkers, including the level of carnitine, and Fibromyalgia. Additionally, for those metabolites demonstrating a causal link to Fibromyalgia in the initial MR analysis, a reverse Mendelian Randomization analysis was conducted to further validate these findings.
Results: Carnitine levels were markedly decreased in patients with fibromyalgia compared with healthy controls. The MR analysis identified 10 metabolites potentially causally linked to fibromyalgia. Among them, carnitine has a causal relationship with Fibromyalgia and is a protective factor (OR 0.73, 95% CI: 0.59– 0.91, p = 0.004). There are others, 4 metabolites showed protective effects, whereas 5 were linked to an elevated risk of the condition. The results were consistent among various MR methods, suggesting a strong correlation.
Conclusion: Our findings provide novel evidence supporting a potential causal, protective role of carnitine in FM pathogenesis, alongside other implicated metabolites. These results highlight the promise of metabolic pathways as targets for intervention, but future studies in larger, diverse populations are warranted to confirm these relationships.
Keywords: fibromyalgia, carnitine, metabolomics, Mendelian randomization