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已发表论文
磷酸化修饰及其在病毒性肺炎中的作用：机制与治疗意义
Authors Wang L, Zhang H , Jiang H
Received 7 September 2025
Accepted for publication 29 November 2025
Published 25 December 2025 Volume 2025:18 Pages 6915—6933
DOI https://doi.org/10.2147/IDR.S562997
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Yan Li
Li Wang,1 Hanwen Zhang,2 Hui Jiang3
1Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People’s Republic of China; 2Department of Pain Management, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China; 3School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, People’s Republic of China
Correspondence: Hui Jiang, Chengdu University of Traditional Chinese Medicine, 1166 Liutai road, Chengdu, Sichuan, 610000, People’s Republic of China, Email jianghui@stu.cdutcm.edu.cn
Abstract: Advances in diagnostic technologies have led to the identification of an increasing number of viruses associated with pneumonia, thereby drawing significant attention to viral pneumonia. The primary viral pathogens implicated in pneumonia include influenza virus, respiratory syncytial virus, coronavirus, adenovirus, parainfluenza virus, human metapneumovirus, and enterovirus. Post-translational modifications, especially phosphorylation, are pivotal in the lifecycle of these viruses. Phosphorylation affects key processes such as viral replication, transcription, assembly, and release, thereby influencing their propagation in host cells. Viral infection can also trigger kinase-associated pathways within host cells, activating host cell phosphatases and related signaling cascades. This results in alterations to host phosphorylation states, aggravating cellular pathology and facilitating viral proliferation. This review examines the common viral pathogens involved in pneumonia and highlights the role of phosphorylation in viral proliferation. Additionally, we explore the potential of phosphorylation inhibitors in controlling viral infections, with the aim of advancing our understanding of viral phosphorylation and promoting the use of these inhibitors in the treatment of viral pneumonia.
Keywords: viral pneumonia, phosphorylation modifications, influenza virus, respiratory syncytial virus, coronaviruses, adenovirus
1Department of Clinical Laboratory, Affiliated Hospital of North Sichuan Medical College, Nanchong, 637000, People’s Republic of China; 2Department of Pain Management, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, People’s Republic of China; 3School of Basic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, People’s Republic of China
Correspondence: Hui Jiang, Chengdu University of Traditional Chinese Medicine, 1166 Liutai road, Chengdu, Sichuan, 610000, People’s Republic of China, Email jianghui@stu.cdutcm.edu.cn
Abstract: Advances in diagnostic technologies have led to the identification of an increasing number of viruses associated with pneumonia, thereby drawing significant attention to viral pneumonia. The primary viral pathogens implicated in pneumonia include influenza virus, respiratory syncytial virus, coronavirus, adenovirus, parainfluenza virus, human metapneumovirus, and enterovirus. Post-translational modifications, especially phosphorylation, are pivotal in the lifecycle of these viruses. Phosphorylation affects key processes such as viral replication, transcription, assembly, and release, thereby influencing their propagation in host cells. Viral infection can also trigger kinase-associated pathways within host cells, activating host cell phosphatases and related signaling cascades. This results in alterations to host phosphorylation states, aggravating cellular pathology and facilitating viral proliferation. This review examines the common viral pathogens involved in pneumonia and highlights the role of phosphorylation in viral proliferation. Additionally, we explore the potential of phosphorylation inhibitors in controlling viral infections, with the aim of advancing our understanding of viral phosphorylation and promoting the use of these inhibitors in the treatment of viral pneumonia.
Keywords: viral pneumonia, phosphorylation modifications, influenza virus, respiratory syncytial virus, coronaviruses, adenovirus