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已发表论文
用于肩关节镜下肩袖修复术间歇肌间沟阻滞的脂质体布比卡因最小有效容量：一项前瞻性、偏币法上下剂量探索研究
Authors Wang HT, Xue Q, Li HJ, Zhao YY , Tian K, Yang JJ
Received 3 August 2025
Accepted for publication 21 December 2025
Published 26 December 2025 Volume 2025:19 Pages 11789—11797
DOI https://doi.org/10.2147/DDDT.S558049
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Tamer Ibrahim
Hai-Tao Wang,1 Qiong Xue,1 Hui-Juan Li,1 Ying-Ying Zhao,1 Ke Tian,2 Jian-Jun Yang1
1Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China
Correspondence: Jian-Jun Yang, Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1 East Jianshe Road, Zhengzhou, People’s Republic of China, Email yjyangjj@126.com
Background: Establishing the minimum effective volume (MEV90) of liposomal bupivacaine for ultrasound guided interscalene brachial plexus block (ISB) is essential to optimize postoperative analgesia and minimize local anesthetic–related side effects in patients undergoing arthroscopic rotator cuff repair. Determining this optimal volume provides a clinically meaningful reference for achieving consistent nerve block success while reducing unnecessary drug exposure and the risk of systemic toxicity. Therefore, the present study aimed to identify the MEV90 of liposomal bupivacaine for ISB in patients undergoing arthroscopic shoulder surgery.
Patients and Methods: This dose-finding study enrolled 51 patients scheduled for arthroscopic rotator cuff repair. Using a biased-coin up-and-down sequential design, patients received varying volumes of liposomal bupivacaine for ultrasound-guided ISB. The MEV90 was determined using centered isotonic regression. The occurrence of adverse events was systematically recorded for 72 hours.
Results: The MEV90 of liposomal bupivacaine for ISB was 10.0mL (90% CI, 9.3 to 12.5mL). A moderate positive correlation was identified between the time to first analgesic request and the volume of liposomal bupivacaine administered (r = 0.6, P < 0.001). Adverse events within 72 hours following the block included dizziness (7.8%), nausea and vomiting (9.8%), and chest discomfort (3.9%).
Conclusion: The MEV90 of liposomal bupivacaine for ultrasound-guided interscalene brachial plexus block in patients undergoing rotator cuff repair surgery was found to be 10.0 mL.
Keywords: bupivacaine, liposomes, brachial plexus blocks, rotator cuff tear arthropathy
1Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China; 2Department of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People’s Republic of China
Correspondence: Jian-Jun Yang, Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, No. 1 East Jianshe Road, Zhengzhou, People’s Republic of China, Email yjyangjj@126.com
Background: Establishing the minimum effective volume (MEV90) of liposomal bupivacaine for ultrasound guided interscalene brachial plexus block (ISB) is essential to optimize postoperative analgesia and minimize local anesthetic–related side effects in patients undergoing arthroscopic rotator cuff repair. Determining this optimal volume provides a clinically meaningful reference for achieving consistent nerve block success while reducing unnecessary drug exposure and the risk of systemic toxicity. Therefore, the present study aimed to identify the MEV90 of liposomal bupivacaine for ISB in patients undergoing arthroscopic shoulder surgery.
Patients and Methods: This dose-finding study enrolled 51 patients scheduled for arthroscopic rotator cuff repair. Using a biased-coin up-and-down sequential design, patients received varying volumes of liposomal bupivacaine for ultrasound-guided ISB. The MEV90 was determined using centered isotonic regression. The occurrence of adverse events was systematically recorded for 72 hours.
Results: The MEV90 of liposomal bupivacaine for ISB was 10.0mL (90% CI, 9.3 to 12.5mL). A moderate positive correlation was identified between the time to first analgesic request and the volume of liposomal bupivacaine administered (r = 0.6, P < 0.001). Adverse events within 72 hours following the block included dizziness (7.8%), nausea and vomiting (9.8%), and chest discomfort (3.9%).
Conclusion: The MEV90 of liposomal bupivacaine for ultrasound-guided interscalene brachial plexus block in patients undergoing rotator cuff repair surgery was found to be 10.0 mL.
Keywords: bupivacaine, liposomes, brachial plexus blocks, rotator cuff tear arthropathy