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已发表论文
幽门螺杆菌根除：为何复发风险不应左右治疗决策
Authors Chen X, Wang Y, Dong Y, Yang J, Xie B, Zhang D
Received 8 September 2025
Accepted for publication 14 December 2025
Published 26 December 2025 Volume 2025:21 Pages 1855—1867
DOI https://doi.org/10.2147/TCRM.S566086
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor De Yun Wang
Xinglan Chen, Yuanyuan Wang, Yeze Dong, Jinxia Yang, Baoyuan Xie, Dekui Zhang
Lanzhou University Second Hospital, Lanzhou, Gansu, 730030, People’s Republic of China
Correspondence: Dekui Zhang, Department of Gastroenterology, Lanzhou University Second Hospital, No. 82 Cuiyingmen, Chengguan District, Lanzhou, Gansu, 730030, People’s Republic of China, Email zhangdk8616@126.com
Abstract: Helicobacter pylori infection is unequivocally associated with the development and progression of various digestive diseases. Clinical guidelines recommend eradication therapy for all eligible patients without contraindications. However, reports of high recurrence rates in earlier studies have raised concerns among clinicians and patients regarding the necessity of treatment, which has, to some extent, hindered the timely implementation of eradication strategies. This article provides a systematic review of the issue of H. pylori recurrence. A comprehensive analysis of literature retrieved from major databases such as PubMed, Web of Science, and Google Scholar, using keywords including “Helicobacter pylori”, “recurrence”, and “reinfection”, indicates that the annual recurrence rate is significantly lower than previously thought, with modern epidemiological estimates ranging from 1.5% to 5.0%. The review further elucidates the underlying mechanisms of recurrence, identifies key modifiable risk factors, and highlights that optimizing eradication regimens and preventing intrafamilial transmission are central strategies for controlling recurrence. The conclusion emphasizes that concerns about recurrence should not preclude eradication therapy and offers a theoretical basis and practical directions for developing targeted prevention strategies in clinical practice.
Keywords: Helicobacter pylori, recurrence rate, reinfection, reactivation, risk factors
Lanzhou University Second Hospital, Lanzhou, Gansu, 730030, People’s Republic of China
Correspondence: Dekui Zhang, Department of Gastroenterology, Lanzhou University Second Hospital, No. 82 Cuiyingmen, Chengguan District, Lanzhou, Gansu, 730030, People’s Republic of China, Email zhangdk8616@126.com
Abstract: Helicobacter pylori infection is unequivocally associated with the development and progression of various digestive diseases. Clinical guidelines recommend eradication therapy for all eligible patients without contraindications. However, reports of high recurrence rates in earlier studies have raised concerns among clinicians and patients regarding the necessity of treatment, which has, to some extent, hindered the timely implementation of eradication strategies. This article provides a systematic review of the issue of H. pylori recurrence. A comprehensive analysis of literature retrieved from major databases such as PubMed, Web of Science, and Google Scholar, using keywords including “Helicobacter pylori”, “recurrence”, and “reinfection”, indicates that the annual recurrence rate is significantly lower than previously thought, with modern epidemiological estimates ranging from 1.5% to 5.0%. The review further elucidates the underlying mechanisms of recurrence, identifies key modifiable risk factors, and highlights that optimizing eradication regimens and preventing intrafamilial transmission are central strategies for controlling recurrence. The conclusion emphasizes that concerns about recurrence should not preclude eradication therapy and offers a theoretical basis and practical directions for developing targeted prevention strategies in clinical practice.
Keywords: Helicobacter pylori, recurrence rate, reinfection, reactivation, risk factors