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已发表论文
抑制气管插管所致血流动力学升高的奥洛他定有效剂量：一种上下序贯试验
Authors Yu J , Wei S , Ling D, Xin Y, Liu H, Yang Y, Li X, Xiang Z, Liu J
Received 16 September 2025
Accepted for publication 23 December 2025
Published 26 December 2025 Volume 2025:19 Pages 11767—11778
DOI https://doi.org/10.2147/DDDT.S567868
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Anastasios Lymperopoulos
Jianmang Yu,1,2,* Shiyou Wei,3,4,* Dandan Ling,4,5,* Yuxuan Xin,3 Hang Liu,3 Yiming Yang,3 Xionggang Li,1 Zhixiong Xiang,1 Jianming Liu3
1Department of Anesthesiology, Tianmen First People’s Hospital, Tianmen, Hubei, 431700, People’s Republic of China; 2Hubei Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, Hubei, 430065, People’s Republic of China; 3Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, People’s Republic of China; 4Outcomes Research® Consortium, Houston, TX, 78299, USA; 5Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, 200032, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jianming Liu, Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, No. 507 Zhengmin Road, Shanghai, 200433, People’s Republic of China, Email liujianming@126.com Zhixiong Xiang, Department of Anesthesiology, Tianmen First People’s Hospital, No. 1 East Jingling Renmin Avenue, Tianmen, Hubei, 431700, People’s Republic of China, Email 28612363@qq.com
Objective: This study aimed to investigate the effective dose of oliceridine for suppressing hemodynamic responses to tracheal intubation during general anesthesia induction and to evaluate the influence of age on dosing requirements, thereby providing evidence for clinical medication protocols.
Methods: A prospective single-center sequential dosing trial was conducted using a modified Dixon’s up-and-down method. Patients scheduled for elective surgery under general anesthesia with tracheal intubation were enrolled and divided into a young group (18– 65 years) and an elderly group (≥ 65 years). The initial doses were 45 μg/kg for the young group and 39 μg/kg for the elderly, with 3 μg/kg adjustments based on intubation response until seven crossovers occurred. A positive cardiovascular response was defined as an increase in mean arterial pressure or heart rate exceeding 20% from baseline within 3 minutes after intubation initiation. ED50 and ED95 values were estimated using Probit regression. Secondary outcomes included the incidence of injection-related cough, sedation success rate (MOAA/S score ≤ 2), peri-intubation hemodynamic changes, and adverse events.
Results: Fifty-eight patients were enrolled (28 young, 30 elderly). The ED50 of oliceridine was 46.5 μg/kg (95% CI 42.0– 51.19) and ED95 was 55.4 μg/kg (95% CI 43.58– 86.56) in the young group. In the elderly group, ED50 was 39.73 μg/kg (95% CI 34.17– 44.76) and ED95 was 50.11 μg/kg (95% CI 37.31– 77.87). Probit models demonstrated good fit in both groups. No injection-related cough reactions were observed, and the sedation success rate was 100%. Heart rate and blood pressure decreased during induction and normalized after intubation, with no significant intergroup differences. Adverse event incidence was comparable between groups.
Conclusion: Under standardized general anesthesia induction, the ED95 of oliceridine for suppressing tracheal intubation-induced hemodynamic elevation shows age-related differences, being approximately 55 μg/kg in younger patients and 50 μg/kg in the elderly.
Clinical Trial Registration: ClinicalTrials.gov, NCT07134660.
Keywords: oliceridine, tracheal intubation, hemodynamics, ED95, dixon’s up-and-down method
1Department of Anesthesiology, Tianmen First People’s Hospital, Tianmen, Hubei, 431700, People’s Republic of China; 2Hubei Key Laboratory of Occupational Hazard Identification and Control, Wuhan University of Science and Technology, Wuhan, Hubei, 430065, People’s Republic of China; 3Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, People’s Republic of China; 4Outcomes Research® Consortium, Houston, TX, 78299, USA; 5Department of Anesthesiology, Fudan University Shanghai Cancer Center, Shanghai, 200032, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jianming Liu, Department of Anesthesiology, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, No. 507 Zhengmin Road, Shanghai, 200433, People’s Republic of China, Email liujianming@126.com Zhixiong Xiang, Department of Anesthesiology, Tianmen First People’s Hospital, No. 1 East Jingling Renmin Avenue, Tianmen, Hubei, 431700, People’s Republic of China, Email 28612363@qq.com
Objective: This study aimed to investigate the effective dose of oliceridine for suppressing hemodynamic responses to tracheal intubation during general anesthesia induction and to evaluate the influence of age on dosing requirements, thereby providing evidence for clinical medication protocols.
Methods: A prospective single-center sequential dosing trial was conducted using a modified Dixon’s up-and-down method. Patients scheduled for elective surgery under general anesthesia with tracheal intubation were enrolled and divided into a young group (18– 65 years) and an elderly group (≥ 65 years). The initial doses were 45 μg/kg for the young group and 39 μg/kg for the elderly, with 3 μg/kg adjustments based on intubation response until seven crossovers occurred. A positive cardiovascular response was defined as an increase in mean arterial pressure or heart rate exceeding 20% from baseline within 3 minutes after intubation initiation. ED50 and ED95 values were estimated using Probit regression. Secondary outcomes included the incidence of injection-related cough, sedation success rate (MOAA/S score ≤ 2), peri-intubation hemodynamic changes, and adverse events.
Results: Fifty-eight patients were enrolled (28 young, 30 elderly). The ED50 of oliceridine was 46.5 μg/kg (95% CI 42.0– 51.19) and ED95 was 55.4 μg/kg (95% CI 43.58– 86.56) in the young group. In the elderly group, ED50 was 39.73 μg/kg (95% CI 34.17– 44.76) and ED95 was 50.11 μg/kg (95% CI 37.31– 77.87). Probit models demonstrated good fit in both groups. No injection-related cough reactions were observed, and the sedation success rate was 100%. Heart rate and blood pressure decreased during induction and normalized after intubation, with no significant intergroup differences. Adverse event incidence was comparable between groups.
Conclusion: Under standardized general anesthesia induction, the ED95 of oliceridine for suppressing tracheal intubation-induced hemodynamic elevation shows age-related differences, being approximately 55 μg/kg in younger patients and 50 μg/kg in the elderly.
Clinical Trial Registration: ClinicalTrials.gov, NCT07134660.
Keywords: oliceridine, tracheal intubation, hemodynamics, ED95, dixon’s up-and-down method