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已发表论文
纳米光疗在肥胖症靶向减脂中的进展：从机制到临床转化
Authors Zhang Y, Qian W, Zhang X, Gao X, Wei Y, Ding J, Zhao H
Received 1 August 2025
Accepted for publication 11 December 2025
Published 23 December 2025 Volume 2025:20 Pages 15549—15568
DOI https://doi.org/10.2147/IJN.S557723
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Sachin Mali
Yi Zhang,* Wenjiang Qian,* Xinling Zhang, Xuejie Gao, Yaqi Wei, Jinping Ding, Hongyi Zhao
Department of Plastic Surgery, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hongyi Zhao, Department of Plastic Surgery, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 da Huaroad, Dongdan, Beijing, 100730, People’s Republic of China, Tel +0086 01013910799717, Fax +0086 010 82267007, Email bjyyzhaohongyi@163.com
Background: Obesity is a global public health concern, and traditional surgical interventions such as liposuction, although effective, carry risks of trauma and complications. Non-invasive phototherapies, including photobiomodulation therapy (PBMT), photodynamic therapy (PDT), and photothermal therapy (PTT), have emerged as promising alternatives.
Methods: This narrative review synthesizes current literature on phototherapy-based fat reduction. A PubMed search was conducted using the terms (“photosensitive material” OR “photodynamic therapy” OR “photothermal” OR “photobiomodulation”) AND (“lipolysis” OR “fat reduction” OR “body contour”). Of 105 studies meeting inclusion criteria, 80 were selected for detailed analysis, focusing on PBMT, PDT, and PTT in non-invasive fat reduction.
Results: PDT induces adipocyte apoptosis and tissue remodeling via ROS generated by photosensitizers; PTT applies near-infrared light to heat adipose tissue, promoting fat cell death and enhancing local metabolic activity; PBMT stimulates mitochondrial activity, accelerating lipolysis and metabolic processes. Some studies indicate that the use of nanomaterials may modestly enhance targeting and therapeutic efficacy.
Conclusion: Non-invasive phototherapy shows great potential in obesity management, and the integration of nanomaterials may further enhance targeting and therapeutic efficacy, enabling safer and more efficient fat reduction. Future studies should optimize phototherapy parameters and explore the synergistic effects of nanomaterials and personalized intervention strategies.
Keywords: nanotechnology, non-invasive techniques, obesity, photobiomodulation, photodynamic therapy, photothermal therapy
Department of Plastic Surgery, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hongyi Zhao, Department of Plastic Surgery, Beijing Hospital, National Center of Gerontology; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No. 1 da Huaroad, Dongdan, Beijing, 100730, People’s Republic of China, Tel +0086 01013910799717, Fax +0086 010 82267007, Email bjyyzhaohongyi@163.com
Background: Obesity is a global public health concern, and traditional surgical interventions such as liposuction, although effective, carry risks of trauma and complications. Non-invasive phototherapies, including photobiomodulation therapy (PBMT), photodynamic therapy (PDT), and photothermal therapy (PTT), have emerged as promising alternatives.
Methods: This narrative review synthesizes current literature on phototherapy-based fat reduction. A PubMed search was conducted using the terms (“photosensitive material” OR “photodynamic therapy” OR “photothermal” OR “photobiomodulation”) AND (“lipolysis” OR “fat reduction” OR “body contour”). Of 105 studies meeting inclusion criteria, 80 were selected for detailed analysis, focusing on PBMT, PDT, and PTT in non-invasive fat reduction.
Results: PDT induces adipocyte apoptosis and tissue remodeling via ROS generated by photosensitizers; PTT applies near-infrared light to heat adipose tissue, promoting fat cell death and enhancing local metabolic activity; PBMT stimulates mitochondrial activity, accelerating lipolysis and metabolic processes. Some studies indicate that the use of nanomaterials may modestly enhance targeting and therapeutic efficacy.
Conclusion: Non-invasive phototherapy shows great potential in obesity management, and the integration of nanomaterials may further enhance targeting and therapeutic efficacy, enabling safer and more efficient fat reduction. Future studies should optimize phototherapy parameters and explore the synergistic effects of nanomaterials and personalized intervention strategies.
Keywords: nanotechnology, non-invasive techniques, obesity, photobiomodulation, photodynamic therapy, photothermal therapy