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已发表论文
极低出生体重儿/超低出生体重儿血清降钙素原（PCT）、C 反应蛋白（CRP）水平与支气管肺发育不良发生/严重程度的相关性分析
Authors Wang J, Zhang S, Dong X, Chen J, Li M
Received 10 August 2025
Accepted for publication 15 November 2025
Published 23 December 2025 Volume 2025:18 Pages 7775—7783
DOI https://doi.org/10.2147/IJGM.S559764
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Reynold Panettieri Jr
Jiaan Wang, Shu Zhang, Xian Dong, Jinwen Chen, Ming Li
Neonatal Department, Hefei Maternal and Child Health Hospital, Hefei, Anhui, 230000, People’s Republic of China
Correspondence: Ming Li, Email d6dnmr@163.com
Objective: This study aimed to analyze the correlation between serum levels of Procalcitonin (PCT) and C-reactive protein (CRP) and the occurrence and severity of Bronchopulmonary Dysplasia (BPD) in Extremely Low Birth Weight (ELBW) and Very Low Birth Weight (VLBW) neonates, and to identify associated risk factors.
Methods: A retrospective analysis was conducted on 213 ELBW/VLBW neonates admitted between January 2021 and January 2024. According to BPD diagnosis, they were categorized into a control group (n=62, without BPD) and an observation group (n=151, with BPD). The observation group was further stratified by severity into mild (n=71), moderate (n=46), and severe (n=34) BPD. Serum PCT and CRP levels were compared across groups. The correlation between these biomarkers and BPD severity was analyzed, and risk factors for BPD were investigated.
Results: PCT and CRP levels were significantly higher in the observation group than in the control group (P< 0.05). A significant increasing trend in both PCT and CRP levels was observed with worsening BPD severity (P< 0.05). Spearman analysis confirmed positive correlations between BPD severity and PCT (r=0.354) and CRP (r=0.472) levels (P< 0.05). Multivariate logistic regression identified intrauterine infection, gestational age < 28 weeks, assisted ventilation > 2 weeks, infectious pneumonia, and FiO2 > 40% as independent risk factors for BPD (P< 0.05).
Conclusion: In this retrospective study, elevated serum PCT and CRP levels were positively associated with the severity of BPD in ELBW/VLBW neonates. The identified risk factors, including intrauterine infection, gestational age < 28 weeks, prolonged assisted ventilation, infectious pneumonia, and high FiO2, are independently associated with BPD. These findings suggest that monitoring these biomarkers and risk factors may warrant intensified clinical attention.
Keywords: extremely and very low birth weight neonates, PCT, CRP, bronchopulmonary dysplasia in children, correlation, risk factors
Neonatal Department, Hefei Maternal and Child Health Hospital, Hefei, Anhui, 230000, People’s Republic of China
Correspondence: Ming Li, Email d6dnmr@163.com
Objective: This study aimed to analyze the correlation between serum levels of Procalcitonin (PCT) and C-reactive protein (CRP) and the occurrence and severity of Bronchopulmonary Dysplasia (BPD) in Extremely Low Birth Weight (ELBW) and Very Low Birth Weight (VLBW) neonates, and to identify associated risk factors.
Methods: A retrospective analysis was conducted on 213 ELBW/VLBW neonates admitted between January 2021 and January 2024. According to BPD diagnosis, they were categorized into a control group (n=62, without BPD) and an observation group (n=151, with BPD). The observation group was further stratified by severity into mild (n=71), moderate (n=46), and severe (n=34) BPD. Serum PCT and CRP levels were compared across groups. The correlation between these biomarkers and BPD severity was analyzed, and risk factors for BPD were investigated.
Results: PCT and CRP levels were significantly higher in the observation group than in the control group (P< 0.05). A significant increasing trend in both PCT and CRP levels was observed with worsening BPD severity (P< 0.05). Spearman analysis confirmed positive correlations between BPD severity and PCT (r=0.354) and CRP (r=0.472) levels (P< 0.05). Multivariate logistic regression identified intrauterine infection, gestational age < 28 weeks, assisted ventilation > 2 weeks, infectious pneumonia, and FiO2 > 40% as independent risk factors for BPD (P< 0.05).
Conclusion: In this retrospective study, elevated serum PCT and CRP levels were positively associated with the severity of BPD in ELBW/VLBW neonates. The identified risk factors, including intrauterine infection, gestational age < 28 weeks, prolonged assisted ventilation, infectious pneumonia, and high FiO2, are independently associated with BPD. These findings suggest that monitoring these biomarkers and risk factors may warrant intensified clinical attention.
Keywords: extremely and very low birth weight neonates, PCT, CRP, bronchopulmonary dysplasia in children, correlation, risk factors