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已发表论文
无阿片类药物麻醉可减轻腹腔镜胆囊切除术患者的术后恶心呕吐：一项随机对照试验的研究方案
Authors Li Y, Hao D, Qi X, Song B
Received 16 June 2025
Accepted for publication 14 December 2025
Published 23 December 2025 Volume 2025:18 Pages 7077—7085
DOI https://doi.org/10.2147/JPR.S542024
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Timothy Atkinson
Ying Li, Dandan Hao, Xiuru Qi, Bijia Song
Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China
Correspondence: Bijia Song, Email songbijia@163.com
Introduction: Postoperative nausea and vomiting (PONV) remains a prevalent complication following laparoscopic cholecystectomy, often linked to perioperative opioid use. This randomized controlled trial aims to evaluate the efficacy of opioid-free anesthesia (OFA) in reducing PONV incidence and improving postoperative recovery quality compared to conventional opioid-based anesthesia (OBA).
Methods/Analysis: This study is a prospective randomized, controlled clinical trial with a concealed allocation of patients scheduled to undergo elective laparoscopic cholecystectomy 1:1 to receive either a standard anesthesia protocol or an OFA. A total of 96 patients were recruited in the study. Primary outcomes include the Rhodes Index of Nausea and Vomiting and the incidence of nausea and vomiting at 6 and 24 hours postoperatively.
Ethics and Dissemination: This trial has been approved by the Institutional Review Board of Beijing Friendship Hospital of China Capital University. The trial study protocol was approved on April 16, 2025, with an anticipated patient recruitment period of 12 months. The ethical approval number was BFHHZS20250091. The trial started recruiting patients after registered on the Chinese Clinical Trial Registry.
Trial Registration Number: CTR2500102278; Pre-results.
Keywords: opioid-free anesthesia, opioid anesthesia, laparoscopic cholecystectomy, postoperative nausea and vomiting
Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, People’s Republic of China
Correspondence: Bijia Song, Email songbijia@163.com
Introduction: Postoperative nausea and vomiting (PONV) remains a prevalent complication following laparoscopic cholecystectomy, often linked to perioperative opioid use. This randomized controlled trial aims to evaluate the efficacy of opioid-free anesthesia (OFA) in reducing PONV incidence and improving postoperative recovery quality compared to conventional opioid-based anesthesia (OBA).
Methods/Analysis: This study is a prospective randomized, controlled clinical trial with a concealed allocation of patients scheduled to undergo elective laparoscopic cholecystectomy 1:1 to receive either a standard anesthesia protocol or an OFA. A total of 96 patients were recruited in the study. Primary outcomes include the Rhodes Index of Nausea and Vomiting and the incidence of nausea and vomiting at 6 and 24 hours postoperatively.
Ethics and Dissemination: This trial has been approved by the Institutional Review Board of Beijing Friendship Hospital of China Capital University. The trial study protocol was approved on April 16, 2025, with an anticipated patient recruitment period of 12 months. The ethical approval number was BFHHZS20250091. The trial started recruiting patients after registered on the Chinese Clinical Trial Registry.
Trial Registration Number: CTR2500102278; Pre-results.
Keywords: opioid-free anesthesia, opioid anesthesia, laparoscopic cholecystectomy, postoperative nausea and vomiting