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已发表论文
临床 ST17 型肺炎克雷伯菌中 tmexCD1-toprJ1 阳性质粒的获得与传播
Authors Zheng L, Zhu J, Qian F, Gao Q, Wen Y , Du H
Received 30 August 2025
Accepted for publication 15 December 2025
Published 24 December 2025 Volume 2025:18 Pages 6825—6834
DOI https://doi.org/10.2147/IDR.S559472
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Hemant Joshi
Lijie Zheng,1,2,* Jie Zhu,1,* Feinan Qian,2 Qizhao Gao,1 Yicheng Wen,1 Hong Du1
1Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 2Department of Clinical Laboratory, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hong Du, Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China, Email hong_du@126.com
Purpose: It is well known that bacteria often acquire drug resistance genes through acquiring exogenous resistant plasmids. The tmexCD1-toprJ1-positive plasmid confers tigecycline resistance to bacterial strains.
Methods: Three sequence type (ST) 17 Klebsiella pneumoniae strains were isolated from two patients within 5 days. Experimental and comparative genomic analyses were performed to investigate potential transmission routes and antimicrobial resistance phenotype disparities.
Results: Strain HD9931 was tigecycline-sensitive, whereas HD9932 and HD10868 were tigecycline-resistant because of the presence of a tmexCD1-toprJ1-positive plasmid. HD10868 exhibited enhanced fitness and greater tigecycline resistance than HD9932 did. Comparative analysis revealed mutations in the AcrAB-TolC efflux pump and lamb in HD9932 and HD10868.
Conclusion: Our study highlights the complexity of resistance gene transfer and underscores the need for continued vigilance and research in this field.
Keywords: tigecycline resistance, tmexCD1-toprJ1, mutation, plasmids
1Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China; 2Department of Clinical Laboratory, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Hong Du, Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of China, Email hong_du@126.com
Purpose: It is well known that bacteria often acquire drug resistance genes through acquiring exogenous resistant plasmids. The tmexCD1-toprJ1-positive plasmid confers tigecycline resistance to bacterial strains.
Methods: Three sequence type (ST) 17 Klebsiella pneumoniae strains were isolated from two patients within 5 days. Experimental and comparative genomic analyses were performed to investigate potential transmission routes and antimicrobial resistance phenotype disparities.
Results: Strain HD9931 was tigecycline-sensitive, whereas HD9932 and HD10868 were tigecycline-resistant because of the presence of a tmexCD1-toprJ1-positive plasmid. HD10868 exhibited enhanced fitness and greater tigecycline resistance than HD9932 did. Comparative analysis revealed mutations in the AcrAB-TolC efflux pump and lamb in HD9932 and HD10868.
Conclusion: Our study highlights the complexity of resistance gene transfer and underscores the need for continued vigilance and research in this field.
Keywords: tigecycline resistance, tmexCD1-toprJ1, mutation, plasmids