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已发表论文
金属纳米粒子：从内生真菌介导的生物合成到其在肿瘤学中的治疗应用
Authors Xie K , Du Y, Zhang J, Liu X, Gan X, Xie N, Hu T, Yang X
Received 21 August 2025
Accepted for publication 11 December 2025
Published 24 December 2025 Volume 2025:20 Pages 15599—15625
DOI https://doi.org/10.2147/IJN.S562203
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Eng San Thian
Kangwei Xie,1 Yusha Du,1 Jiatong Zhang,1 Xinling Liu,1 Xiujuan Gan,1 Niqi Xie,2 Tieyi Hu,3 Xingyong Yang1
1College of Pharmacy, Chengdu University, Chengdu, 610106, People’s Republic of China; 2Department of Laboratory Medicine, the Affiliated Dazu’s Hospital of Chongqing Medical University, Chongqing, 402360, People’s Republic of China; 3Department of Neurology, the Affiliated Dazu’s Hospital of Chongqing Medical University, Chongqing, 402360, People’s Republic of China
Correspondence: Xingyong Yang, College of Pharmacy, Chengdu University, Chengdu, 610106, People’s Republic of China, Email yangxingyong@cdu.edu.cn Tieyi Hu, Department of Neurology, the Affiliated Dazu’s Hospital of Chongqing Medical University, Chongqing, 402360, People’s Republic of China, Email 150233@hospital.cqmu.edu.cn
Abstract: Metal nanoparticles possess unique properties and usage patterns compared to traditional materials owing to their distinctive structures. In recent years, their application scenarios and dosages have considerably expanded. Biosynthetic nanoparticles, particularly those derived from endophytic fungi that help host organisms in adapting to heavy metal environments, hold substantial value and potential for application. This is largely attributed to their simplicity, cost-effectiveness, and energy efficiency. The present review provides an overview of the entire process of metal nanoparticle biosynthesis by plant endophytic fungi and illustrates various scenarios of their applications in oncology treatment. In addition to focusing on the preparation of metal nanoparticles using plant endophytic fungi, this review also explores the characterization of these nanoparticles and clarifies the synthesis mechanisms, including the synthetic pathways and the roles of fungal enzymes. It also comprehensively summarizes the application of biosynthetic metal nanoparticles in cancer, covering their role in diagnosis, enhancement of drug biocompatibility, and improvement of therapeutic efficacy. These nanoparticles exhibit toxicity toward cancer cells by generating reactive oxygen species and inducing oxidative stress, ultimately leading to the death of malignant cells. The biosynthesis of metal nanoparticles by plant endophytic fungi represents a promising, green, and environmentally friendly approach with potential applications in various fields, including cancer treatment, in the future.
Keywords: endophytic fungi, metal nanoparticles, biosynthesis, cancer therapy
1College of Pharmacy, Chengdu University, Chengdu, 610106, People’s Republic of China; 2Department of Laboratory Medicine, the Affiliated Dazu’s Hospital of Chongqing Medical University, Chongqing, 402360, People’s Republic of China; 3Department of Neurology, the Affiliated Dazu’s Hospital of Chongqing Medical University, Chongqing, 402360, People’s Republic of China
Correspondence: Xingyong Yang, College of Pharmacy, Chengdu University, Chengdu, 610106, People’s Republic of China, Email yangxingyong@cdu.edu.cn Tieyi Hu, Department of Neurology, the Affiliated Dazu’s Hospital of Chongqing Medical University, Chongqing, 402360, People’s Republic of China, Email 150233@hospital.cqmu.edu.cn
Abstract: Metal nanoparticles possess unique properties and usage patterns compared to traditional materials owing to their distinctive structures. In recent years, their application scenarios and dosages have considerably expanded. Biosynthetic nanoparticles, particularly those derived from endophytic fungi that help host organisms in adapting to heavy metal environments, hold substantial value and potential for application. This is largely attributed to their simplicity, cost-effectiveness, and energy efficiency. The present review provides an overview of the entire process of metal nanoparticle biosynthesis by plant endophytic fungi and illustrates various scenarios of their applications in oncology treatment. In addition to focusing on the preparation of metal nanoparticles using plant endophytic fungi, this review also explores the characterization of these nanoparticles and clarifies the synthesis mechanisms, including the synthetic pathways and the roles of fungal enzymes. It also comprehensively summarizes the application of biosynthetic metal nanoparticles in cancer, covering their role in diagnosis, enhancement of drug biocompatibility, and improvement of therapeutic efficacy. These nanoparticles exhibit toxicity toward cancer cells by generating reactive oxygen species and inducing oxidative stress, ultimately leading to the death of malignant cells. The biosynthesis of metal nanoparticles by plant endophytic fungi represents a promising, green, and environmentally friendly approach with potential applications in various fields, including cancer treatment, in the future.
Keywords: endophytic fungi, metal nanoparticles, biosynthesis, cancer therapy