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已发表论文
中国东部一家三级教学医院临床病原体的分布特征及耐药趋势：一项回顾性研究（2020 - 2024 年）
Authors Liu L , Huang Y, Jiang Y, Wang Y, Liu K, Pei Z, Li Z, Zhu Y, Lu J, Li X
Received 13 October 2025
Accepted for publication 17 December 2025
Published 24 December 2025 Volume 2025:18 Pages 6889—6903
DOI https://doi.org/10.2147/IDR.S573970
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Oliver Planz
Lili Liu,1,* Yuan Huang,2,* Yunlan Jiang,1 Yaping Wang,3 Kang Liu,3 Zhongxia Pei,1 Zhiping Li,1 Yuqiong Zhu,1 Ji Lu,1 Xiaoyue Li4
1Department of Hospital-Acquired Infections, Anqing First People’s Hospital of Anhui Province, Anqing, Anhui, People’s Republic of China; 2Division of Education and Science, Anqing Municipal Hospital, Anqing, Anhui, People’s Republic of China; 3Clinical Laboratory Department, Anqing First People’s Hospital of Anhui Province, Anqing, Anhui, People’s Republic of China; 4Subdean Office, Anqing First People’s Hospital of Anhui Province, Anqing, Anhui, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaoyue Li, Email 18496701@qq.com
Purpose: To examine the distribution of clinical pathogens and their antimicrobial resistance trends in a hospital in East China to provide evidence for rational antibiotic use and infection control.
Methods: We conducted a retrospective study of bacterial isolates from January 2020 to December 2024. Bacterial identification and antimicrobial susceptibility testing were performed using the VITEK 2 system. WHONET 5.6 and R software were used for data analysis. Statistical analyses included chi-square tests and trend tests.
Results: A total of 8680 pathogenic isolates were collected. Gram-negative bacteria predominated (74.7%) over Gram-positive bacteria (25.3%). The primary specimens were urine (33.7%), sputum (25.3%), and secretions (19.4%). The leading pathogens were E. coli (28.4%), K. pneumoniae (12.8%), and P. aeruginosa (11.5%). The carbapenem resistance rate was less than 1.9% in Escherichia coli strains over five years. The rate for carbapenem resistant K. pneumoniae (CRKP) showed a significant increasing trend, rising from 9.4% in 2022 to 16.7% in 2024 (p< 0.05). CRKP rates were lower than national CHINET data. The imipenem resistance rate of Pseudomonas aeruginosa exhibited an upward trend from 2020 (24.2%) to 2023 (34.1%) (p< 0.05). A. baumannii maintained high resistance to imipenem (> 73%), exceeding national levels. The proportion of methicillin-resistant Staphylococcus aureus (MRSA) fluctuated over the course of the five years (26.9– 44.8%). No vancomycin-resistant Enterococcus (VRE) was detected.
Conclusion: E. coli, K. pneumoniae, and P. aeruginosa were the predominant pathogens in this hospital. The rising and high resistance rates of CRKP and CRAB highlight the urgent need for enhanced antimicrobial stewardship. &Bgr;-lactamase, β-lactamase inhibitor combination preparations and carbapenems were recommended for susceptible strains of E. coli and K. pneumoniae. For CRKP infections and CRAB infections, tigecycline and colistin are recommended. Continuous surveillance and infection control are crucial to combat the evolving threat of multidrug-resistant organisms.
Keywords: bacterial resistance surveillance, multi-drug resistant organism, rational application of antibiotics, hospital associated infection
1Department of Hospital-Acquired Infections, Anqing First People’s Hospital of Anhui Province, Anqing, Anhui, People’s Republic of China; 2Division of Education and Science, Anqing Municipal Hospital, Anqing, Anhui, People’s Republic of China; 3Clinical Laboratory Department, Anqing First People’s Hospital of Anhui Province, Anqing, Anhui, People’s Republic of China; 4Subdean Office, Anqing First People’s Hospital of Anhui Province, Anqing, Anhui, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaoyue Li, Email 18496701@qq.com
Purpose: To examine the distribution of clinical pathogens and their antimicrobial resistance trends in a hospital in East China to provide evidence for rational antibiotic use and infection control.
Methods: We conducted a retrospective study of bacterial isolates from January 2020 to December 2024. Bacterial identification and antimicrobial susceptibility testing were performed using the VITEK 2 system. WHONET 5.6 and R software were used for data analysis. Statistical analyses included chi-square tests and trend tests.
Results: A total of 8680 pathogenic isolates were collected. Gram-negative bacteria predominated (74.7%) over Gram-positive bacteria (25.3%). The primary specimens were urine (33.7%), sputum (25.3%), and secretions (19.4%). The leading pathogens were E. coli (28.4%), K. pneumoniae (12.8%), and P. aeruginosa (11.5%). The carbapenem resistance rate was less than 1.9% in Escherichia coli strains over five years. The rate for carbapenem resistant K. pneumoniae (CRKP) showed a significant increasing trend, rising from 9.4% in 2022 to 16.7% in 2024 (p< 0.05). CRKP rates were lower than national CHINET data. The imipenem resistance rate of Pseudomonas aeruginosa exhibited an upward trend from 2020 (24.2%) to 2023 (34.1%) (p< 0.05). A. baumannii maintained high resistance to imipenem (> 73%), exceeding national levels. The proportion of methicillin-resistant Staphylococcus aureus (MRSA) fluctuated over the course of the five years (26.9– 44.8%). No vancomycin-resistant Enterococcus (VRE) was detected.
Conclusion: E. coli, K. pneumoniae, and P. aeruginosa were the predominant pathogens in this hospital. The rising and high resistance rates of CRKP and CRAB highlight the urgent need for enhanced antimicrobial stewardship. &Bgr;-lactamase, β-lactamase inhibitor combination preparations and carbapenems were recommended for susceptible strains of E. coli and K. pneumoniae. For CRKP infections and CRAB infections, tigecycline and colistin are recommended. Continuous surveillance and infection control are crucial to combat the evolving threat of multidrug-resistant organisms.
Keywords: bacterial resistance surveillance, multi-drug resistant organism, rational application of antibiotics, hospital associated infection