114027
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
靶向金属离子稳态以实现细胞程序性死亡放大的肿瘤纳米药物
Authors Chen Q, Li K, Li J , Liu X, Li J, Xu L, Han Y, Zou T, Wang X, Yao Y , Mao Y
Received 1 October 2025
Accepted for publication 11 December 2025
Published 24 December 2025 Volume 2025:20 Pages 15627—15654
DOI https://doi.org/10.2147/IJN.S571617
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Sachin Mali
Qiqing Chen,1,* Kun Li,2,* Jinzhuo Li,3 Xue Liu,4 Jiaxin Li,5 Lianuang Xu,5 Yabing Han,5 Ting Zou,5 Xingrong Wang,5 Yangcheng Yao,6 Yuhang Mao5
1Department of Ultrasound, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, People’s Republic of China; 2Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 3Faculty of Health Sciences, University of Macau, Macau, SAR, 999078, People’s Republic of China; 4Department of Biological Chemical Engineering, College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin, 300222, People’s Republic of China; 5School of Medicine, Ankang University, Ankang, 725000, People’s Republic of China; 6Center for Reproductive Medicine, Guangdong Women and Children Hospital, Jinan University, Guangzhou, 511400, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yangcheng Yao, Email yyc233@jnu.edu.cn Yuhang Mao, Email maoyuhang@aku.edu.cn
Abstract: Amidst escalating global health challenges, neoplastic diseases remain a predominant cause of morbidity and mortality, exerting complex and far-reaching effects on human health and societal well-being. The advent of precision medicine has ushered in an era of tailored therapeutic strategies, leveraging individual genetic profiles, tumor microenvironmental features, and exogenous factors to redefine oncology care. Central to these advances is the understanding of cell death, a fundamental biological process encompassing both programmed and non-programmed forms. Programmed cell death is orchestrated through sophisticated genetic and molecular mechanisms. Emerging evidence underscores the role of metal ion dyshomeostasis, particularly of iron, copper, zinc, sodium, magnesium, manganese, and calcium, in disrupting intracellular signaling and metabolic equilibrium, thereby inducing lethal cascades in malignant cells. Concurrently, innovations in nanomedicine have enabled precise modulation of ion fluxes within tumors, enhancing therapeutic specificity while minimizing systemic toxicity. This confluence of ion-mediated cell death mechanisms and nanotechnology not only exemplifies a transformative approach in cancer treatment but also aligns seamlessly with the tenets of precision medicine, offering novel pathways for therapeutic innovation and clinical translation.
Keywords: regulated cell death, metal ion-induced cell death, tumor nanomedicine, precision cancer therapy
1Department of Ultrasound, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, 570311, People’s Republic of China; 2Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, 200433, People’s Republic of China; 3Faculty of Health Sciences, University of Macau, Macau, SAR, 999078, People’s Republic of China; 4Department of Biological Chemical Engineering, College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin, 300222, People’s Republic of China; 5School of Medicine, Ankang University, Ankang, 725000, People’s Republic of China; 6Center for Reproductive Medicine, Guangdong Women and Children Hospital, Jinan University, Guangzhou, 511400, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yangcheng Yao, Email yyc233@jnu.edu.cn Yuhang Mao, Email maoyuhang@aku.edu.cn
Abstract: Amidst escalating global health challenges, neoplastic diseases remain a predominant cause of morbidity and mortality, exerting complex and far-reaching effects on human health and societal well-being. The advent of precision medicine has ushered in an era of tailored therapeutic strategies, leveraging individual genetic profiles, tumor microenvironmental features, and exogenous factors to redefine oncology care. Central to these advances is the understanding of cell death, a fundamental biological process encompassing both programmed and non-programmed forms. Programmed cell death is orchestrated through sophisticated genetic and molecular mechanisms. Emerging evidence underscores the role of metal ion dyshomeostasis, particularly of iron, copper, zinc, sodium, magnesium, manganese, and calcium, in disrupting intracellular signaling and metabolic equilibrium, thereby inducing lethal cascades in malignant cells. Concurrently, innovations in nanomedicine have enabled precise modulation of ion fluxes within tumors, enhancing therapeutic specificity while minimizing systemic toxicity. This confluence of ion-mediated cell death mechanisms and nanotechnology not only exemplifies a transformative approach in cancer treatment but also aligns seamlessly with the tenets of precision medicine, offering novel pathways for therapeutic innovation and clinical translation.
Keywords: regulated cell death, metal ion-induced cell death, tumor nanomedicine, precision cancer therapy