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介孔硅酸镁掺入聚（ε - 己内酯） - 聚（乙二醇） - 聚（ε - 己内酯）的生物活性复合物有利成骨细胞的行为

 

Authors Niu Y, Dong W, Guo H, Deng Y, Guo L, An X, He D, Wei J, Li M

Published Date May 2014 Volume 2014:9(1) Pages 2665—2675

DOI http://dx.doi.org/10.2147/IJN.S59040

Received 11 December 2013, Accepted 7 February 2014, Published 27 May 2014

 
Abstract: Mesoporous magnesium silicate (m-MS) and poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) (PCL-PEG-PCL) composite (m-MPC) was synthesized by solvent casting method. The results suggest that the mechanical properties of compressive strength and elastic modulus, as well as hydrophilicity, of the m-MPC increased with increase of m-MS content in the composites. In addition, the weight loss of the m-MPC improved significantly with the increase of m-MS content during composite soaking in phosphate-buffered saline for 10 weeks, indicating that incorporation of m-MS into PCL-PEG-PCL could enhance the degradability of the m-MPC. Moreover, the m-MPC with 40 w% m-MS could induce a dense and continuous apatite layer on its surface after soaking in simulated body fluid for 5 days, which was better than m-MPC 20 w% m-MS, exhibiting excellent in vitro bioactivity. In cell cultural experiments, the results showed that the attachment and viability ratio of MG63 cells on m-MPC increased significantly with the increase of m-MS content, showing that the addition of m-MS into PCL-PEG-PCL could promote cell attachment and proliferation. The results suggest that the incorporation of m-MS into PCL-PEG-PCL could produce bioactive composites with improved hydrophilicity, degradability, bioactivity, and cytocompatibility.
Keywords: PCL-PEG-PCL, degradation, cytocompatibility, cell attachment, cell proliferation






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