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已发表论文
用于先进抗肿瘤药物递送系统的刺激响应型 MXene 纳米材料
Authors Deng P, Ling Z, Fang F, Ruan J, Yang C, Hu R, Zhou J, Xiong P
Received 8 July 2025
Accepted for publication 23 October 2025
Published 4 November 2025 Volume 2025:20 Pages 13317—13332
DOI https://doi.org/10.2147/IJN.S552112
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Dr Yan Shen
Peng Deng,1,* Zhihong Ling,1,* Fei Fang,2 Jishi Ruan,1 Chuanjun Yang,1 Rong Hu,1 Jing Zhou,3 Peizheng Xiong4
1Department of Oncology, The Fourth People’s Hospital of Sichuan Province, Chengdu, People’s Republic of China; 2Department of General Surgery, The 955th Hospital of Army, Changdu, People’s Republic of China; 3Department of Endocrinology, The Fourth People’s Hospital of Sichuan Province, Chengdu, People’s Republic of China; 4Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jing Zhou, Department of Endocrinology, the Fourth People’s Hospital of Sichuan Province, Chengdu, People’s Republic of China, Email 18919894832@163.com Peizheng Xiong, Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China, Email xiongpeizheng@cdutcm.edu.cn
Abstract: MXene, a novel class of two-dimensional nanomaterials, has garnered significant attention for antitumor drug delivery due to its exceptional properties, including high specific surface area, excellent photothermal conversion efficiency, and tunable surface chemistry. Given the limitations of traditional cancer therapies, such as systemic toxicity and poor tumor targeting, MXene-based nanocarriers offer a promising solution. This review summarizes the intelligent responsive nano-drug delivery system constructed with MXene nanomaterials as a drug carrier material, as well as the research progress of endogenous stimulation (pH value and redox microenvironment), exogenous stimulation (photoheat and ultrasound), and multistimulus-responsive MXene nanomaterials. The aim is to provide valuable insights and inspirations for the further development of effective and safe MXene nanomaterials with antitumor properties.
Keywords: MXene, stimuli-response, antitumor, drug delivery system, review
1Department of Oncology, The Fourth People’s Hospital of Sichuan Province, Chengdu, People’s Republic of China; 2Department of General Surgery, The 955th Hospital of Army, Changdu, People’s Republic of China; 3Department of Endocrinology, The Fourth People’s Hospital of Sichuan Province, Chengdu, People’s Republic of China; 4Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jing Zhou, Department of Endocrinology, the Fourth People’s Hospital of Sichuan Province, Chengdu, People’s Republic of China, Email 18919894832@163.com Peizheng Xiong, Department of Otorhinolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China, Email xiongpeizheng@cdutcm.edu.cn
Abstract: MXene, a novel class of two-dimensional nanomaterials, has garnered significant attention for antitumor drug delivery due to its exceptional properties, including high specific surface area, excellent photothermal conversion efficiency, and tunable surface chemistry. Given the limitations of traditional cancer therapies, such as systemic toxicity and poor tumor targeting, MXene-based nanocarriers offer a promising solution. This review summarizes the intelligent responsive nano-drug delivery system constructed with MXene nanomaterials as a drug carrier material, as well as the research progress of endogenous stimulation (pH value and redox microenvironment), exogenous stimulation (photoheat and ultrasound), and multistimulus-responsive MXene nanomaterials. The aim is to provide valuable insights and inspirations for the further development of effective and safe MXene nanomaterials with antitumor properties.
Keywords: MXene, stimuli-response, antitumor, drug delivery system, review