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已发表论文
心力衰竭与焦虑共病的知识领域及新兴趋势：一项科学计量分析
Authors Yang D, Duan S, Lu X, Long Y, Tao S , Zhu H, Li R, Li L
Received 4 August 2025
Accepted for publication 22 October 2025
Published 5 November 2025 Volume 2025:18 Pages 7175—7191
DOI https://doi.org/10.2147/JMDH.S558108
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Charles V Pollack
Deshuang Yang,1,* Shaojie Duan,2,* Xiaoyan Lu,1,* Yujia Long,3,* Shiyi Tao,3 Huimin Zhu,2 Rui Li,4 Lin Li1
1Department of Integrative Cardiology, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Department of Geriatrics, Taizhou Central Hospital (Taizhou University Hospital), Zhejiang, People’s Republic of China; 3Graduate School, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 4Department of Geriatrics, China-Japan Friendship Hospital, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Rui Li, Department of Geriatrics, China-Japan Friendship Hospital, No. 2 Yinghua East Street, Chaoyang Distinct, Beijing, 100029, People’s Republic of China, Email rainyrui@163.com Lin Li, Department of Integrative Cardiology, China-Japan Friendship Hospital, No. 2 Yinghua East Street, Chaoyang Distinct, Beijing, 100029, People’s Republic of China, Email lilinxcy@126.com
Objective: The high prevalence of anxiety disorders among heart failure (HF) patients significantly impacts clinical outcomes, yet a comprehensive analysis of the global research landscape is lacking. This study explores research trends, knowledge structure, and emerging hotspots in the field of HF and anxiety comorbidity over the past decade.
Methods: A bibliometric analysis was conducted on 1,475 publications from the Web of Science Core Collection (2015– 2024). A total of 1,475 English-language publications, including articles and reviews, were analyzed. CiteSpace and VOSviewer were used to analyze collaboration networks, references, and keywords. The search tool for the retrieval of interacting genes database was applied to construct a protein-protein interaction (PPI) network of HF and anxiety comorbidity. R with clusterProfiler was applied to perform kyoto encyclopedia of genes and genomes pathway enrichment analysis. Cytoscape was applied to visualize both the PPI network and the significant pathways.
Results: Annual publications increased steadily, peaking in 2021. The United States of America and China emerged as the most productive countries. Key contributors included Linkoping University and Harvard Medical School. Keyword analysis revealed evolving focuses from mortality and depression to self-care, cardiac rehabilitation, and psychological assessment tools. Gene intersection analysis identified 124 shared genes, with hub genes such as AKT1, TP53, and IL6 implicated in MAPK, FoxO, and JAK-STAT signaling pathways. These results suggest neuroendocrine and inflammatory mechanisms linking HF and anxiety.
Conclusion: This study offers the bibliometric and molecular insight into the HF and anxiety comorbidity landscape. While research output and mechanistic understanding have grown, gaps remain in standardized assessment and clinical translation. Future studies should focus on translating these mechanistic insights into strategies that improve integrated care and quality of life for patients living with the dual burden of heart failure and anxiety.
Keywords: heart failure, anxiety disorders, bibliometric analysis, gene enrichment, comorbidity
1Department of Integrative Cardiology, China-Japan Friendship Hospital, Beijing, People’s Republic of China; 2Department of Geriatrics, Taizhou Central Hospital (Taizhou University Hospital), Zhejiang, People’s Republic of China; 3Graduate School, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 4Department of Geriatrics, China-Japan Friendship Hospital, Beijing, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Rui Li, Department of Geriatrics, China-Japan Friendship Hospital, No. 2 Yinghua East Street, Chaoyang Distinct, Beijing, 100029, People’s Republic of China, Email rainyrui@163.com Lin Li, Department of Integrative Cardiology, China-Japan Friendship Hospital, No. 2 Yinghua East Street, Chaoyang Distinct, Beijing, 100029, People’s Republic of China, Email lilinxcy@126.com
Objective: The high prevalence of anxiety disorders among heart failure (HF) patients significantly impacts clinical outcomes, yet a comprehensive analysis of the global research landscape is lacking. This study explores research trends, knowledge structure, and emerging hotspots in the field of HF and anxiety comorbidity over the past decade.
Methods: A bibliometric analysis was conducted on 1,475 publications from the Web of Science Core Collection (2015– 2024). A total of 1,475 English-language publications, including articles and reviews, were analyzed. CiteSpace and VOSviewer were used to analyze collaboration networks, references, and keywords. The search tool for the retrieval of interacting genes database was applied to construct a protein-protein interaction (PPI) network of HF and anxiety comorbidity. R with clusterProfiler was applied to perform kyoto encyclopedia of genes and genomes pathway enrichment analysis. Cytoscape was applied to visualize both the PPI network and the significant pathways.
Results: Annual publications increased steadily, peaking in 2021. The United States of America and China emerged as the most productive countries. Key contributors included Linkoping University and Harvard Medical School. Keyword analysis revealed evolving focuses from mortality and depression to self-care, cardiac rehabilitation, and psychological assessment tools. Gene intersection analysis identified 124 shared genes, with hub genes such as AKT1, TP53, and IL6 implicated in MAPK, FoxO, and JAK-STAT signaling pathways. These results suggest neuroendocrine and inflammatory mechanisms linking HF and anxiety.
Conclusion: This study offers the bibliometric and molecular insight into the HF and anxiety comorbidity landscape. While research output and mechanistic understanding have grown, gaps remain in standardized assessment and clinical translation. Future studies should focus on translating these mechanistic insights into strategies that improve integrated care and quality of life for patients living with the dual burden of heart failure and anxiety.
Keywords: heart failure, anxiety disorders, bibliometric analysis, gene enrichment, comorbidity