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已发表论文
儿童对室内过敏原的敏感性动力学差异：新冠疫情期间居家隔离期间尘螨过敏早期激增与猫皮屑过敏延迟高峰
Authors Zhang Y, Fu X, Chen Y, Yang F, Xing Z, Li D, Ren Z, Ren F, Chen Y
Received 28 July 2025
Accepted for publication 22 October 2025
Published 5 November 2025 Volume 2025:18 Pages 1539—1549
DOI https://doi.org/10.2147/JAA.S556457
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Luis Garcia-Marcos
Yi Zhang,1 Xiaoying Fu,1 Yang Chen,2 Fanghua Yang,1 Zhihao Xing,3 Dongyan Li,1 Zhangchi Ren,4 Feng Ren,2,* Yunsheng Chen1,*
1Department of Laboratory Medicine, Shenzhen Children’s Hospital, Shenzhen, Guangdong, People’s Republic of China; 2Department of Surgery, Shenzhen Children’s Hospital, Shenzhen, Guangdong, People’s Republic of China; 3Biobank & Clinical Laboratory, Shenzhen Children’s Hospital, Shenzhen, Guangdong, People’s Republic of China; 4Shenzhen Senior High School Chuangxin HighSchool, Shenzhen, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Feng Ren, Department of Surgery, Shenzhen Children’s Hospital, Shenzhen, Guangdong, 518000, People’s Republic of China, Email 283311729@qq.com Yunsheng Chen, Department of Laboratory Medicine, Shenzhen Children’s Hospital, Shenzhen, Guangdong, 518000, People’s Republic of China, Email chenyunshenglw@163.com
Purpose: The COVID-19 pandemic altered patterns of indoor allergen exposure. However, longitudinal dynamics of sensitization kinetics across allergens remain poorly characterized. This study delineated allergen-specific sensitization dynamics during 2019– 2022, contrasting responses to dust mites and cat dander.
Patients and Methods: The retrospective cohort study of 43,314 children (0– 17 years) in Shenzhen, China, analyzed specific IgE (sIgE) reactivity. Adjusted odds ratios (aORs) were calculated using logistic regression (adjusted for age/sex; 2019 baseline) and E-values assessed unmeasured confounding.
Results: Dust mite sensitization increased significantly in 2020 (Dermatophagoides pteronyssinusfarinae aOR = 1.291.42, 95% CI: 1.16– 1.441.29– 1.57, both P < 0.001), declined in 2021, and partially rebounded in 2022. Conversely, cat dander sensitization exhibited a delayed peak, rising significantly only by 2022 (aOR = 1.83, 95% CI: 1.30– 2.65, P < 0.001, E-value = 3.07). German cockroach sensitization decreased by 35% in 2022 (aOR = 0.65, 95% CI: 0.54– 0.78, P < 0.001, E-value = 2.26). Adolescents (6– 17 years) showed heightened cat dander sensitization (2022: aOR = 2.05, P =0.001, E-value = 3.52), while males had steeper cockroach declines (2022: aOR = 0.61, P < 0.001). Food sensitization remained stable except wheat (aOR = 0.80, P =0.005).
Conclusion: We identify distinct allergen-specific dynamics. Dust mites acted as early-response allergens linked to confinement intensity, while cat dander emerged as delayed-response allergens likely driven by cumulative behavioral and exposure changes. Targeted environmental interventions (eg, pest control) significantly reduced cockroach sensitization. These findings advocate for allergen-tailored, time-resolved prevention strategies during public health crises, with priority protection for adolescents.
Clinical Trial Registration: National Medical Research Registration Information System/MR-44-24-056093.
Keywords: COVID-19 pandemic, allergen sensitization kinetics, allergen-specific immunoglobulin E, pediatric allergy
1Department of Laboratory Medicine, Shenzhen Children’s Hospital, Shenzhen, Guangdong, People’s Republic of China; 2Department of Surgery, Shenzhen Children’s Hospital, Shenzhen, Guangdong, People’s Republic of China; 3Biobank & Clinical Laboratory, Shenzhen Children’s Hospital, Shenzhen, Guangdong, People’s Republic of China; 4Shenzhen Senior High School Chuangxin HighSchool, Shenzhen, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Feng Ren, Department of Surgery, Shenzhen Children’s Hospital, Shenzhen, Guangdong, 518000, People’s Republic of China, Email 283311729@qq.com Yunsheng Chen, Department of Laboratory Medicine, Shenzhen Children’s Hospital, Shenzhen, Guangdong, 518000, People’s Republic of China, Email chenyunshenglw@163.com
Purpose: The COVID-19 pandemic altered patterns of indoor allergen exposure. However, longitudinal dynamics of sensitization kinetics across allergens remain poorly characterized. This study delineated allergen-specific sensitization dynamics during 2019– 2022, contrasting responses to dust mites and cat dander.
Patients and Methods: The retrospective cohort study of 43,314 children (0– 17 years) in Shenzhen, China, analyzed specific IgE (sIgE) reactivity. Adjusted odds ratios (aORs) were calculated using logistic regression (adjusted for age/sex; 2019 baseline) and E-values assessed unmeasured confounding.
Results: Dust mite sensitization increased significantly in 2020 (Dermatophagoides pteronyssinusfarinae aOR = 1.291.42, 95% CI: 1.16– 1.441.29– 1.57, both P < 0.001), declined in 2021, and partially rebounded in 2022. Conversely, cat dander sensitization exhibited a delayed peak, rising significantly only by 2022 (aOR = 1.83, 95% CI: 1.30– 2.65, P < 0.001, E-value = 3.07). German cockroach sensitization decreased by 35% in 2022 (aOR = 0.65, 95% CI: 0.54– 0.78, P < 0.001, E-value = 2.26). Adolescents (6– 17 years) showed heightened cat dander sensitization (2022: aOR = 2.05, P =0.001, E-value = 3.52), while males had steeper cockroach declines (2022: aOR = 0.61, P < 0.001). Food sensitization remained stable except wheat (aOR = 0.80, P =0.005).
Conclusion: We identify distinct allergen-specific dynamics. Dust mites acted as early-response allergens linked to confinement intensity, while cat dander emerged as delayed-response allergens likely driven by cumulative behavioral and exposure changes. Targeted environmental interventions (eg, pest control) significantly reduced cockroach sensitization. These findings advocate for allergen-tailored, time-resolved prevention strategies during public health crises, with priority protection for adolescents.
Clinical Trial Registration: National Medical Research Registration Information System/MR-44-24-056093.
Keywords: COVID-19 pandemic, allergen sensitization kinetics, allergen-specific immunoglobulin E, pediatric allergy