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已发表论文
肿瘤护理干预对肺癌患者化疗所致毒性的影响
Received 9 June 2025
Accepted for publication 11 October 2025
Published 6 November 2025 Volume 2025:21 Pages 1549—1558
DOI https://doi.org/10.2147/TCRM.S545756
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 5
Editor who approved publication: Professor Garry Walsh
Ya Gao,1 Mei Guo2
1Department of Ward I, Chest Medicine, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430079, People’s Republic of China; 2Department of Intra-Abdominal II, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430079, People’s Republic of China
Correspondence: Mei Guo, Department of Intra-abdominal II, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, 116 Zhuodaoquan South Road, Hongshan District, Wuhan, Hubei, 430079, People’s Republic of China, Email gm328682213gmgm@163.com
Background: Chemotherapy-induced toxicities are a significant challenge in lung cancer treatment, leading to reduced treatment adherence, increased hospital readmissions, and lower quality of life. Oncology nursing plays a vital role in managing these toxicities through early assessment, patient education, and supportive care. This study aimed to evaluate the impact of a structured oncology nursing intervention on the management of chemotherapy-related toxicities in lung cancer patients.
Methods: This retrospective cohort study analyzed 313 patients with pathologically confirmed lung cancer who received first-line chemotherapy at Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, between January 2021 and December 2023. Patients were divided into two groups: the intervention group (n = 148) received comprehensive oncology nursing services, including toxicity education, symptom monitoring via telephone follow-up, early triage of adverse events, and individualized supportive care plans; the control group (n = 165) received standard care. Primary outcomes included the incidence and severity of grade ≥ 2 chemotherapy toxicities, unscheduled hospital visits, and treatment delays. Secondary outcomes included patient satisfaction and anxiety levels.
Results: The intervention group showed a significantly lower incidence of grade ≥ 2 neutropenia (18.2% vs 30.3%, P = 0.012), chemotherapy-induced nausea/vomiting (24.3% vs 39.4%, P = 0.006), and unplanned emergency visits (9.5% vs 19.4%, P = 0.018). Treatment delays due to unmanaged toxicity were also reduced (12.8% vs 23.0%, P = 0.021). Additionally, the intervention group reported lower anxiety scores (mean STAI: 34.7 vs 41.3, P < 0.001) and higher satisfaction (8.7 vs 7.4, P < 0.001).
Conclusion: Structured oncology nursing interventions significantly improve the management of chemotherapy-induced toxicities in lung cancer patients, reducing complications, enhancing treatment continuity, and improving psychological well-being.
Keywords: lung cancer, chemotherapy toxicity, oncology nursing, supportive care, nursing intervention, patient satisfaction, retrospective study
1Department of Ward I, Chest Medicine, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430079, People’s Republic of China; 2Department of Intra-Abdominal II, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430079, People’s Republic of China
Correspondence: Mei Guo, Department of Intra-abdominal II, Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, 116 Zhuodaoquan South Road, Hongshan District, Wuhan, Hubei, 430079, People’s Republic of China, Email gm328682213gmgm@163.com
Background: Chemotherapy-induced toxicities are a significant challenge in lung cancer treatment, leading to reduced treatment adherence, increased hospital readmissions, and lower quality of life. Oncology nursing plays a vital role in managing these toxicities through early assessment, patient education, and supportive care. This study aimed to evaluate the impact of a structured oncology nursing intervention on the management of chemotherapy-related toxicities in lung cancer patients.
Methods: This retrospective cohort study analyzed 313 patients with pathologically confirmed lung cancer who received first-line chemotherapy at Hubei Cancer Hospital, Tongji Medical College, Huazhong University of Science and Technology, between January 2021 and December 2023. Patients were divided into two groups: the intervention group (n = 148) received comprehensive oncology nursing services, including toxicity education, symptom monitoring via telephone follow-up, early triage of adverse events, and individualized supportive care plans; the control group (n = 165) received standard care. Primary outcomes included the incidence and severity of grade ≥ 2 chemotherapy toxicities, unscheduled hospital visits, and treatment delays. Secondary outcomes included patient satisfaction and anxiety levels.
Results: The intervention group showed a significantly lower incidence of grade ≥ 2 neutropenia (18.2% vs 30.3%, P = 0.012), chemotherapy-induced nausea/vomiting (24.3% vs 39.4%, P = 0.006), and unplanned emergency visits (9.5% vs 19.4%, P = 0.018). Treatment delays due to unmanaged toxicity were also reduced (12.8% vs 23.0%, P = 0.021). Additionally, the intervention group reported lower anxiety scores (mean STAI: 34.7 vs 41.3, P < 0.001) and higher satisfaction (8.7 vs 7.4, P < 0.001).
Conclusion: Structured oncology nursing interventions significantly improve the management of chemotherapy-induced toxicities in lung cancer patients, reducing complications, enhancing treatment continuity, and improving psychological well-being.
Keywords: lung cancer, chemotherapy toxicity, oncology nursing, supportive care, nursing intervention, patient satisfaction, retrospective study