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已发表论文
生活方式、脂质组与多囊卵巢综合征之间的因果关系：一项孟德尔随机化研究
Received 28 May 2025
Accepted for publication 2 October 2025
Published 7 November 2025 Volume 2025:17 Pages 4291—4300
DOI https://doi.org/10.2147/IJWH.S531967
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Matteo Frigerio
Xiaoping Kou, Xiao Jing
Reproductive Medicine Department, Xi’an Gaoxin Hospital, Xi’an, Shaanxi, 710075, People’s Republic of China
Correspondence: Xiao Jing, Reproductive Medicine Department, Xi’an Gaoxin Hospital, No. 16, Tuanjie South Road, High-Tech Industrial Development Zone, Xi’an, Shaanxi, 710075, People’s Republic of China, Tel +8618049667647, Email xxjxjxiaojing@163.com
Background: Lifestyle interventions often influence lipid levels in patients with polycystic ovary syndrome (PCOS), thereby modulating disease progression. However, whether lipid levels play a mediating role remains unclear.
Objective: To investigate causal associations between lifestyle, lipidome, and PCOS, as well as mediating role of lipidome.
Methods: This study employed a bidirectional two-sample Mendelian randomization (MR) analysis, with lifestyle and lipidome as exposures and PCOS as outcome. A two-step MR approach was used to assess mediating role of lipidome. Inverse-variance weighted (IVW) method was primarily applied, and sensitivity analyses were conducted to test robustness of results.
Results: Overall physical activity time (OR = 0.590, 95% CI: 0.394– 0.882, P = 0.010) was significantly negatively associated with PCOS risk, while leisure screen time (OR = 1.377, 95% CI: 1.050– 1.804, P = 0.021) was significantly positively associated with PCOS risk. 25 lipid levels were significantly associated with PCOS risk, with 3 showing negative correlations and 22 showing positive correlations (P < 0.05). Mediation analysis revealed that TAG (50:1) (triacylglycerol with 50 carbon atoms and 1 double bond) levels mediated causal relationship between increased overall physical activity time and lowered PCOS risk. The median effect accounted for 23.8% of the total effect (B = − 0.126, 95% CI: − 0.238 to − 0.014, P = 0.027).
Conclusion: This study revealed causal associations between overall physical activity time, leisure screen time, and PCOS, and identified mediating role of TAG (50:1) levels. These findings provide scientific insights for lifestyle management in PCOS patients.
Keywords: lifestyle, lipidome, polycystic ovary syndrome, mendelian randomization
Reproductive Medicine Department, Xi’an Gaoxin Hospital, Xi’an, Shaanxi, 710075, People’s Republic of China
Correspondence: Xiao Jing, Reproductive Medicine Department, Xi’an Gaoxin Hospital, No. 16, Tuanjie South Road, High-Tech Industrial Development Zone, Xi’an, Shaanxi, 710075, People’s Republic of China, Tel +8618049667647, Email xxjxjxiaojing@163.com
Background: Lifestyle interventions often influence lipid levels in patients with polycystic ovary syndrome (PCOS), thereby modulating disease progression. However, whether lipid levels play a mediating role remains unclear.
Objective: To investigate causal associations between lifestyle, lipidome, and PCOS, as well as mediating role of lipidome.
Methods: This study employed a bidirectional two-sample Mendelian randomization (MR) analysis, with lifestyle and lipidome as exposures and PCOS as outcome. A two-step MR approach was used to assess mediating role of lipidome. Inverse-variance weighted (IVW) method was primarily applied, and sensitivity analyses were conducted to test robustness of results.
Results: Overall physical activity time (OR = 0.590, 95% CI: 0.394– 0.882, P = 0.010) was significantly negatively associated with PCOS risk, while leisure screen time (OR = 1.377, 95% CI: 1.050– 1.804, P = 0.021) was significantly positively associated with PCOS risk. 25 lipid levels were significantly associated with PCOS risk, with 3 showing negative correlations and 22 showing positive correlations (P < 0.05). Mediation analysis revealed that TAG (50:1) (triacylglycerol with 50 carbon atoms and 1 double bond) levels mediated causal relationship between increased overall physical activity time and lowered PCOS risk. The median effect accounted for 23.8% of the total effect (B = − 0.126, 95% CI: − 0.238 to − 0.014, P = 0.027).
Conclusion: This study revealed causal associations between overall physical activity time, leisure screen time, and PCOS, and identified mediating role of TAG (50:1) levels. These findings provide scientific insights for lifestyle management in PCOS patients.
Keywords: lifestyle, lipidome, polycystic ovary syndrome, mendelian randomization