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已发表论文
青少年原发性肝癌的临床意义与新认知：是青少年群体的噩梦吗？
Authors Guo H , Chen X, Li R, Shen J, Gan D, Yin Y, Zhang H, Xie J, Xie L , Liu Y
Received 7 May 2025
Accepted for publication 17 October 2025
Published 7 November 2025 Volume 2025:12 Pages 2513—2540
DOI https://doi.org/10.2147/JHC.S538084
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Jörg Trojan
Huidong Guo,1,* Xiaojun Chen,2,* Rong Li,3,* Jianzhen Shen,4 Donghui Gan,2 Yue Yin,4 Hehui Zhang,1 Jiachen Xie,1 Longfei Xie,1 Yanquan Liu5
1The First Affiliated Hospital (First Clinical Medical College) of Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of China; 2School of Medicine, Putian University, The Affiliated Hospital of Putian University, Putian, Fujian, People’s Republic of China; 3The Third Affiliated Hospital of Naval Medical University (Eastern Hepatobiliary Surgery Hospital), Shanghai, People’s Republic of China; 4Union Clinical Medical College, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; 5Jiangxi Health Commission Key Laboratory of Leukemia, the Affiliated Ganzhou Hospital (Ganzhou People’s Hospital), Jiangxi Medical College, Nanchang University, Ganzhou, Jiangxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yanquan Liu, Jiangxi Health Commission Key Laboratory of Leukemia, the Affiliated Ganzhou Hospital, Jiangxi Medical College, Nanchang University, Ganzhou, Jiangxi, People’s Republic of China, Email doctorliuyanquan@gdmu.edu.cn Longfei Xie, The First Affiliated Hospital (First Clinical Medical College) of Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of China, Email 18370806419@163.com
Objective: This study retrospectively analyzed clinical data from adolescent primary liver cancer (PLC) cases over the past decade, summarizing clinical characteristics, diagnostic approaches, and prognostic outcomes to provide guidance for prevention, early diagnosis, and timely treatment of adolescent PLC.
Methods: Clinical data of 497 cases of adolescent PLC patients were collected from January 1, 2014, to December 31, 2024. The baseline demographic data, general condition, imaging, laboratory findings, and pathological features of these patients were described, and the diagnostic and therapeutic processes were analyzed, univariate and multivariate Cox regression analyses were conducted to identify significant prognostic factors.
Results: The age of onset for patients was 13.75 (10.25– 19.00) years, with 311 males (62.58%) and 186 females (37.42%), yielding a male-to-female ratio of 1.67:1. Elevated ALT and GGT levels were observed in most patients, while all patients exhibited elevated ChE. Among all patients included in this study, 320 cases (64.39%) were infected with HBV, 469 cases (94.36%) were diagnosed with hepatocellular carcinoma (HCC), 14 cases (2.82%) with intrahepatic cholangiocarcinoma, and 14 cases (2.82%) with mixed hepatocellular-intrahepatic cholangiocarcinoma. The follow-up results showed the 1-year, 2-year, and 3-year survival rates in adolescent PLC patients were 45.27%, 20.32%, and 8.45%, respectively. The univariate Cox regression analysis revealed that adolescent PLC patients who accompanied with portal vein tumor thrombus, ascites, advanced CNLC stage, abnormalities in AFP, ALT, AST, AST/ALT ratio, GGT, ALP and TBIL, high ECOG score and non-surgical treatment had shorter OS (P < 0.05). Multivariate Cox regression analysis showed that portal vein tumor thrombus, advanced CNLC stage, abnormalities in AFP, GGT, and non-surgical treatment were independent prognostic factors influencing the OS of adolescent PLC patients (P < 0.05).
Conclusion: Clinical manifestations and symptoms of adolescent PLC patients lack specificity, and portal vein tumor thrombus, advanced CNLC stage, abnormalities in AFP, GGT, and non-surgical treatment were independent prognostic factors influencing OS in adolescent PLC.
Keywords: adolescents, primary liver cancer, clinical characteristics, prognosis, risk factors, special population, malignant tumor
1The First Affiliated Hospital (First Clinical Medical College) of Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of China; 2School of Medicine, Putian University, The Affiliated Hospital of Putian University, Putian, Fujian, People’s Republic of China; 3The Third Affiliated Hospital of Naval Medical University (Eastern Hepatobiliary Surgery Hospital), Shanghai, People’s Republic of China; 4Union Clinical Medical College, Fujian Medical University Union Hospital, Fuzhou, Fujian, People’s Republic of China; 5Jiangxi Health Commission Key Laboratory of Leukemia, the Affiliated Ganzhou Hospital (Ganzhou People’s Hospital), Jiangxi Medical College, Nanchang University, Ganzhou, Jiangxi, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yanquan Liu, Jiangxi Health Commission Key Laboratory of Leukemia, the Affiliated Ganzhou Hospital, Jiangxi Medical College, Nanchang University, Ganzhou, Jiangxi, People’s Republic of China, Email doctorliuyanquan@gdmu.edu.cn Longfei Xie, The First Affiliated Hospital (First Clinical Medical College) of Gannan Medical University, Ganzhou, Jiangxi, People’s Republic of China, Email 18370806419@163.com
Objective: This study retrospectively analyzed clinical data from adolescent primary liver cancer (PLC) cases over the past decade, summarizing clinical characteristics, diagnostic approaches, and prognostic outcomes to provide guidance for prevention, early diagnosis, and timely treatment of adolescent PLC.
Methods: Clinical data of 497 cases of adolescent PLC patients were collected from January 1, 2014, to December 31, 2024. The baseline demographic data, general condition, imaging, laboratory findings, and pathological features of these patients were described, and the diagnostic and therapeutic processes were analyzed, univariate and multivariate Cox regression analyses were conducted to identify significant prognostic factors.
Results: The age of onset for patients was 13.75 (10.25– 19.00) years, with 311 males (62.58%) and 186 females (37.42%), yielding a male-to-female ratio of 1.67:1. Elevated ALT and GGT levels were observed in most patients, while all patients exhibited elevated ChE. Among all patients included in this study, 320 cases (64.39%) were infected with HBV, 469 cases (94.36%) were diagnosed with hepatocellular carcinoma (HCC), 14 cases (2.82%) with intrahepatic cholangiocarcinoma, and 14 cases (2.82%) with mixed hepatocellular-intrahepatic cholangiocarcinoma. The follow-up results showed the 1-year, 2-year, and 3-year survival rates in adolescent PLC patients were 45.27%, 20.32%, and 8.45%, respectively. The univariate Cox regression analysis revealed that adolescent PLC patients who accompanied with portal vein tumor thrombus, ascites, advanced CNLC stage, abnormalities in AFP, ALT, AST, AST/ALT ratio, GGT, ALP and TBIL, high ECOG score and non-surgical treatment had shorter OS (P < 0.05). Multivariate Cox regression analysis showed that portal vein tumor thrombus, advanced CNLC stage, abnormalities in AFP, GGT, and non-surgical treatment were independent prognostic factors influencing the OS of adolescent PLC patients (P < 0.05).
Conclusion: Clinical manifestations and symptoms of adolescent PLC patients lack specificity, and portal vein tumor thrombus, advanced CNLC stage, abnormalities in AFP, GGT, and non-surgical treatment were independent prognostic factors influencing OS in adolescent PLC.
Keywords: adolescents, primary liver cancer, clinical characteristics, prognosis, risk factors, special population, malignant tumor