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已发表论文
从现代病理生理学视角看中医对痛风的综合治疗
Authors Yang J, Xu R, Li K, Han J, Tong Y
Received 26 May 2025
Accepted for publication 8 October 2025
Published 7 November 2025 Volume 2025:18 Pages 6783—6801
DOI https://doi.org/10.2147/IJGM.S542924
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Daniela Opriș-Belinski
Jiamin Yang,1 Rui Xu,2 Kaiqing Li,1 Jiachen Han,1 Ying Tong2
1Department of Graduate School, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150006, People’s Republic of China; 2Department of Rheumatology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China
Correspondence: Ying Tong, Department of Rheumatology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China, Email tongying@hljucm.edu.cn
Abstract: Gout, a prevalent metabolic disorder characterized by elevated uric acid levels, has numerous adverse health implications. Current medical therapies can control symptoms and lower uric acid, yet they are often limited by adverse effects and incomplete long-term efficacy. Traditional Chinese Medicine (TCM) has a long history of application in gout and is reported to provide advantages in both prevention and management. To evaluate its role from a modern biomedical perspective, this review systematically examined literature retrieved from PubMed, CNKI, and Web of Science up to 2024, covering randomized controlled trials, observational studies, and mechanistic investigations. The reviewed evidence indicates that TCM interventions, including classical herbal formulations and acupuncture, have been associated with improvements in inflammatory regulation, uric acid metabolism, symptom relief, and recurrence prevention. Moreover, experimental studies suggest potential protective effects on renal function and joint structures. By integrating clinical data with mechanistic insights, this review aims to provide a comprehensive overview of the therapeutic potential of TCM in gout and to outline directions for future translational and clinical research.
Keywords: gout, gout attack, MSU, inflammatory reaction, TCM
1Department of Graduate School, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150006, People’s Republic of China; 2Department of Rheumatology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China
Correspondence: Ying Tong, Department of Rheumatology, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, 150040, People’s Republic of China, Email tongying@hljucm.edu.cn
Abstract: Gout, a prevalent metabolic disorder characterized by elevated uric acid levels, has numerous adverse health implications. Current medical therapies can control symptoms and lower uric acid, yet they are often limited by adverse effects and incomplete long-term efficacy. Traditional Chinese Medicine (TCM) has a long history of application in gout and is reported to provide advantages in both prevention and management. To evaluate its role from a modern biomedical perspective, this review systematically examined literature retrieved from PubMed, CNKI, and Web of Science up to 2024, covering randomized controlled trials, observational studies, and mechanistic investigations. The reviewed evidence indicates that TCM interventions, including classical herbal formulations and acupuncture, have been associated with improvements in inflammatory regulation, uric acid metabolism, symptom relief, and recurrence prevention. Moreover, experimental studies suggest potential protective effects on renal function and joint structures. By integrating clinical data with mechanistic insights, this review aims to provide a comprehensive overview of the therapeutic potential of TCM in gout and to outline directions for future translational and clinical research.
Keywords: gout, gout attack, MSU, inflammatory reaction, TCM