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已发表论文
急性缺血性脑卒中溶栓患者葡萄糖钾比值的预后价值及其与炎症的相互作用
Authors Lin L, Zhang R, Wang J, Fan Y, Xie W, Yu B, Lou J, Pan Y, Chen C, Huang S, Chen G , Weng Y
Received 11 July 2025
Accepted for publication 22 October 2025
Published 7 November 2025 Volume 2025:20 Pages 1913—1925
DOI https://doi.org/10.2147/CIA.S553110
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Maddalena Illario
Lingling Lin,1,* Rui Zhang,2,3,* Jianing Wang,4,* Yichuan Fan,2,5 Wei Xie,2,6 Bohuai Yu,2,6 Jialing Lou,2,6 Yanyi Pan,2,6 Chao Chen,7 Suwen Huang,2 Guangyong Chen,1 Yiyun Weng2
1Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Renji College, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 4Department of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 5Alberta Institute, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 6The First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 7Department of Nutriology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Guangyong Chen, Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China, Email gychen@wmu.edu.cn Yiyun Weng, Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China, Email wengyiyun2012@126.com
Objective: The glucose-to-potassium ratio (GPR) has been proven to be an early predictor of central nervous system injury. Meanwhile, it has a potential interaction with the inflammatory response. Therefore, we aimed to comprehensively analyze the prognostic value of GPR for thrombolytic acute ischemic stroke (AIS) patients and its synergistic effect with the neutrophil-to-lymphocyte ratio (NLR).
Methods: AIS patients treated with thrombolysis were retrospectively enrolled at the First Affiliated Hospital of Wenzhou Medical University between February 1st, 2018, and December 31st, 2021. Cox and Logistic regression were used for evaluating the predictive value of GPR for the prognosis of AIS patients. Patients were grouped according to GPR and NLR levels to study the synergistic effect of GPR and NLR.
Results: In a cohort of 606 patients, after adjusting for significant confounding factors in a multivariate regression analysis, GPR was able to independently predict adverse outcomes such as 6-mRS [odds ratio (OR) = 1.743, 95% confidence interval (CI): 1.271– 2.389, p = 0.001]. The synergistic analysis of GPR and NLR showed that for 6-mRS, GPR-H/NLR-L (OR = 2.888, 95% CI: 1.213– 6.874, p = 0.017), GPR-H/NLR-M (OR = 2.757, 95% CI: 1.179– 6.447, p = 0.019) and GPR-H/NLR-H (OR = 5.195, 95% CI: 2.320– 11.634, p < 0.001) were significantly associated with adverse outcomes.
Conclusion: GPR independently predicts adverse outcomes in AIS patients, and its addition to the prediction model improves predictive accuracy. There’s a synergistic effect between GPR and NLR on adverse outcomes.
Keywords: glucose-to-potassium ratio, neutrophil-to-lymphocyte ratio, acute ischemic stroke
1Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 2Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 3Renji College, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 4Department of Neurology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 5Alberta Institute, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 6The First School of Medicine, School of Information and Engineering, Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 7Department of Nutriology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Guangyong Chen, Department of Neurology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China, Email gychen@wmu.edu.cn Yiyun Weng, Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, People’s Republic of China, Email wengyiyun2012@126.com
Objective: The glucose-to-potassium ratio (GPR) has been proven to be an early predictor of central nervous system injury. Meanwhile, it has a potential interaction with the inflammatory response. Therefore, we aimed to comprehensively analyze the prognostic value of GPR for thrombolytic acute ischemic stroke (AIS) patients and its synergistic effect with the neutrophil-to-lymphocyte ratio (NLR).
Methods: AIS patients treated with thrombolysis were retrospectively enrolled at the First Affiliated Hospital of Wenzhou Medical University between February 1st, 2018, and December 31st, 2021. Cox and Logistic regression were used for evaluating the predictive value of GPR for the prognosis of AIS patients. Patients were grouped according to GPR and NLR levels to study the synergistic effect of GPR and NLR.
Results: In a cohort of 606 patients, after adjusting for significant confounding factors in a multivariate regression analysis, GPR was able to independently predict adverse outcomes such as 6-mRS [odds ratio (OR) = 1.743, 95% confidence interval (CI): 1.271– 2.389, p = 0.001]. The synergistic analysis of GPR and NLR showed that for 6-mRS, GPR-H/NLR-L (OR = 2.888, 95% CI: 1.213– 6.874, p = 0.017), GPR-H/NLR-M (OR = 2.757, 95% CI: 1.179– 6.447, p = 0.019) and GPR-H/NLR-H (OR = 5.195, 95% CI: 2.320– 11.634, p < 0.001) were significantly associated with adverse outcomes.
Conclusion: GPR independently predicts adverse outcomes in AIS patients, and its addition to the prediction model improves predictive accuracy. There’s a synergistic effect between GPR and NLR on adverse outcomes.
Keywords: glucose-to-potassium ratio, neutrophil-to-lymphocyte ratio, acute ischemic stroke