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已发表论文
由 SARS-CoV-2 和甲型流感病毒感染所致膈肌膨出：两例报告
Authors Zheng W, Zhang X , Zheng Y , Xu T
Received 30 July 2025
Accepted for publication 31 October 2025
Published 7 November 2025 Volume 2025:18 Pages 5781—5787
DOI https://doi.org/10.2147/IDR.S557019
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Dr Alberto Ospina Stella
Wei Zheng,1 Xiaojing Zhang,2 Yafeng Zheng,2 Tao Xu1
1Department of Respiratory and Critical Care Medicine, The Affiliated People’s Hospital of Ningbo University, Ningbo, Zhejiang, 315040, People’s Republic of China; 2WillingMed Technology (Beijing) Co., Ltd, Beijing, People’s Republic of China
Correspondence: Wei Zheng, Department of Respiratory and Critical Care Medicine, The Affiliated People’s Hospital of Ningbo University, Ningbo, People’s Republic of China, Email zw2130609@163.com
Abstract: Diaphragmatic eventration (DE) denotes abnormal elevation of the diaphragm due to paralysis, hypoplasia, or atrophy and is classed as either congenital or acquired. In this report, one case involved a patient with congenital localized DE who developed persistent symptoms such as cough, sputum production, chest tightness, and shortness of breath after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Imaging studies ultimately revealed progression to complete DE. The patient underwent surgical intervention and recovered well postoperatively. The other case involved a patient who developed chest tightness, shortness of breath, cough, and sputum production after infection with Influenza A virus. Chest CT imaging confirmed localized DE. Although antiviral treatment alleviated the symptoms, the diaphragmatic elevation remained. This study demonstrates that both SARS-CoV-2 and influenza virus infections can potentially damage the phrenic nerve, leading to subsequent diaphragmatic dysfunction. Early recognition and intervention can effectively prevent progression of DE and ensure prompt, effective treatment.
Keywords: diaphragmatic eventration, SARS-CoV-2, influenza A virus, diaphragmatic dysfunction, case report
1Department of Respiratory and Critical Care Medicine, The Affiliated People’s Hospital of Ningbo University, Ningbo, Zhejiang, 315040, People’s Republic of China; 2WillingMed Technology (Beijing) Co., Ltd, Beijing, People’s Republic of China
Correspondence: Wei Zheng, Department of Respiratory and Critical Care Medicine, The Affiliated People’s Hospital of Ningbo University, Ningbo, People’s Republic of China, Email zw2130609@163.com
Abstract: Diaphragmatic eventration (DE) denotes abnormal elevation of the diaphragm due to paralysis, hypoplasia, or atrophy and is classed as either congenital or acquired. In this report, one case involved a patient with congenital localized DE who developed persistent symptoms such as cough, sputum production, chest tightness, and shortness of breath after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Imaging studies ultimately revealed progression to complete DE. The patient underwent surgical intervention and recovered well postoperatively. The other case involved a patient who developed chest tightness, shortness of breath, cough, and sputum production after infection with Influenza A virus. Chest CT imaging confirmed localized DE. Although antiviral treatment alleviated the symptoms, the diaphragmatic elevation remained. This study demonstrates that both SARS-CoV-2 and influenza virus infections can potentially damage the phrenic nerve, leading to subsequent diaphragmatic dysfunction. Early recognition and intervention can effectively prevent progression of DE and ensure prompt, effective treatment.
Keywords: diaphragmatic eventration, SARS-CoV-2, influenza A virus, diaphragmatic dysfunction, case report