已发表论文

肝细胞癌根治性切除或消融术后的复发风险因素

 

Authors Meng F, Wang J, Zhu XD, Zhang M , Zhang X, Cheng D , Zhang X, Liu L

Received 8 July 2025

Accepted for publication 7 October 2025

Published 6 November 2025 Volume 2025:12 Pages 2501—2511 

DOI https://doi.org/10.2147/JHC.S552316

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Dr Ali Hosni

Fanzheng Meng,1– 3 Jizhou Wang,1– 3 Xiao-Dong Zhu,4 Meng Zhang,5 Xiaowu Zhang,6 Dantong Cheng,7 Xijie Zhang,7 Lianxin Liu1– 3 

1Department of Hepatobiliary Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People’s Republic of China; 2Anhui Provincial Key Laboratory of Hepatopancreatobiliary Surgery, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, People’s Republic of China; 3Anhui Provincial Clinical Research Center for Hepatobiliary Diseases, The First Affiliated Hospital of USTC, University of Science and Technology of China, Hefei, People’s Republic of China; 4Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; 5Department of Hepatobiliary Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 6Department of Interventional Therapy, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China; 7Value & Implementation, Global Medical & Scientific Affairs, MSD China, Shanghai, People’s Republic of China

Correspondence: Lianxin Liu, Email liulx@ustc.edu.cn
摘要

肝细胞癌(HCC)是最常见的肝脏恶性肿瘤,在中国的发病率很高,主要归因于乙型肝炎病毒(HBV)的高感染率。HBV相关的HCC常表现出侵袭性特征,但患者肝功能往往相对保留。手术切除和消融是可达到潜在治愈效果的治疗方法,然而术后复发率很高,5年内复发率可达70%。在中国,根治性切除或消融的适应证较西方更为宽泛,因此识别高危复发患者至关重要:风险分层有助于指导术后管理,包括监测频率的调整以及避免过度或不足治疗。基线临床病理特征提供了一种简单的风险预测方法,但对早期与晚期复发的影响不同。据我们所知,这是首篇全面了解中国肝细胞癌患者根治性切除或消融后早期和晚期复发的复发风险因素的识别、发生率及影响的描述性综述。早期复发的最重要风险因素是肿瘤的侵袭性特征,包括肿瘤大小、数目和血管侵袭。晚期复发更为关键的风险因素为患者特征,如性别、病毒感染和肝硬化。鉴于这些风险因素相互关联,已有多种综合风险预测模型被提出,包括列线图及基于人工智能的应用,这些方法有望提高风险分层的准确性并指导个体化管理,但要实现临床应用,仍需在大型前瞻性队列中进一步加以验证。