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已发表论文
口服胆钙化醇对维生素 D 不足或缺乏患者慢性伤口愈合的影响
Authors Zhao H, Wu X , Li H, Lan Y
Received 28 May 2025
Accepted for publication 17 October 2025
Published 24 October 2025 Volume 2025:18 Pages 6887—6900
DOI https://doi.org/10.2147/JMDH.S543380
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Pavani Rangachari
Hui Zhao,1 Xiaokun Wu,2 Haiyan Li,3 Yutao Lan1
1Department of Nursing, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 2Department of Nursing, Foshan Hospital of Traditional Chinese Medicine, Foshan, People’s Republic of China; 3Director of Nursing, Guangzhou Red Cross Hospital, Guangzhou, People’s Republic of China
Correspondence: Yutao Lan, Department of Nursing, Guangdong Pharmaceutical University, Jianghai Street No. 283, Haizhu District, Guangzhou, 510315, People’s Republic of China, Tel +86-13710667351, Email lanyutao@gdpu.edu.cn
Background: Chronic wounds significantly impact patients’ physical and mental health. Several individuals with chronic wounds have low vitamin D levels. Most previous studies have concentrated primarily on diabetic foot ulcers. Few investigations have explored the effects of vitamin D supplementation on different types of chronic wounds.
Purpose: This study aimed to evaluate the impact of increasing serum 25-hydroxyvitamin D (25(OH)D) concentration on participants with chronic wounds and vitamin D insufficiency or deficiency following cholecalciferol (vitamin D3) supplementation. Additionally, it explored the combined effects of wound care and vitamin D supplementation on wound healing outcomes.
Patients and Methods: A total of 46 participants with chronic wounds who were admitted to a wound ostomy care clinic between February and December 2023 were enrolled and randomly assigned to intervention (n=23) and control (n=23) groups. Both groups received local wound treatment based on the tissue, infection, moisture, and edge (TIME) principles and were advised on dietary changes and sunlight exposure. The intervention group received 6000 international units (IUs) of oral cholecalciferol daily until week 5, after which doses were adjusted based on serum concentration.
Results: Of the 46 participants, 40 completed the study with 57 chronic wounds. Per-protocol analysis revealed a statistically significant difference in serum 25(OH)D concentration between the two groups at week 5 (mean ± standard deviation (SD): 36.75± 7.23 vs 29.58± 5.29 ng/mL, P< 0.01). The intervention group had a shorter average wound healing time than the control group (mean ± SD: 15.59± 6.27 vs 26.16± 12.70 days, P< 0.01). Additionally, wound area reduction rate, wound depth reduction rate, and pressure ulcer scale for healing (PUSH) scores were significantly higher in the intervention group (P< 0.05).
Conclusion: These findings suggest that oral cholecalciferol supplementation increases 25(OH)D concentrations and promotes chronic wound healing.
Trial Registration: This trial was registered at the Chinese Clinical Trial Registry (https://www.chictr.org.cn/, Registration No. ChiCTR2200065482) on November 6, 2022.
Keywords: chronic wound, wound healing, vitamin D, serum 25-hydroxyvitamin D, cholecalciferol
1Department of Nursing, Guangdong Pharmaceutical University, Guangzhou, People’s Republic of China; 2Department of Nursing, Foshan Hospital of Traditional Chinese Medicine, Foshan, People’s Republic of China; 3Director of Nursing, Guangzhou Red Cross Hospital, Guangzhou, People’s Republic of China
Correspondence: Yutao Lan, Department of Nursing, Guangdong Pharmaceutical University, Jianghai Street No. 283, Haizhu District, Guangzhou, 510315, People’s Republic of China, Tel +86-13710667351, Email lanyutao@gdpu.edu.cn
Background: Chronic wounds significantly impact patients’ physical and mental health. Several individuals with chronic wounds have low vitamin D levels. Most previous studies have concentrated primarily on diabetic foot ulcers. Few investigations have explored the effects of vitamin D supplementation on different types of chronic wounds.
Purpose: This study aimed to evaluate the impact of increasing serum 25-hydroxyvitamin D (25(OH)D) concentration on participants with chronic wounds and vitamin D insufficiency or deficiency following cholecalciferol (vitamin D3) supplementation. Additionally, it explored the combined effects of wound care and vitamin D supplementation on wound healing outcomes.
Patients and Methods: A total of 46 participants with chronic wounds who were admitted to a wound ostomy care clinic between February and December 2023 were enrolled and randomly assigned to intervention (n=23) and control (n=23) groups. Both groups received local wound treatment based on the tissue, infection, moisture, and edge (TIME) principles and were advised on dietary changes and sunlight exposure. The intervention group received 6000 international units (IUs) of oral cholecalciferol daily until week 5, after which doses were adjusted based on serum concentration.
Results: Of the 46 participants, 40 completed the study with 57 chronic wounds. Per-protocol analysis revealed a statistically significant difference in serum 25(OH)D concentration between the two groups at week 5 (mean ± standard deviation (SD): 36.75± 7.23 vs 29.58± 5.29 ng/mL, P< 0.01). The intervention group had a shorter average wound healing time than the control group (mean ± SD: 15.59± 6.27 vs 26.16± 12.70 days, P< 0.01). Additionally, wound area reduction rate, wound depth reduction rate, and pressure ulcer scale for healing (PUSH) scores were significantly higher in the intervention group (P< 0.05).
Conclusion: These findings suggest that oral cholecalciferol supplementation increases 25(OH)D concentrations and promotes chronic wound healing.
Trial Registration: This trial was registered at the Chinese Clinical Trial Registry (https://www.chictr.org.cn/, Registration No. ChiCTR2200065482) on November 6, 2022.
Keywords: chronic wound, wound healing, vitamin D, serum 25-hydroxyvitamin D, cholecalciferol