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已发表论文
305 例 IB - IIA 期宫颈鳞状细胞癌手术治疗患者的临床病理特征及生存结局回顾性研究
Authors Huang L, Zeng W, Chen L, Liang Y, Lin H, Hou T
Received 12 May 2025
Accepted for publication 19 September 2025
Published 24 October 2025 Volume 2025:17 Pages 3855—3863
DOI https://doi.org/10.2147/IJWH.S529011
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Matteo Frigerio
Lishan Huang, Weihong Zeng, Li Chen, Ye Liang, Haihong Lin, Tao Hou
Department of Gynecology, Meizhou People’s Hospital, Meizhou City, Guangdong Province, 514031, People’s Republic of China
Correspondence: Tao Hou, Department of Gynecology, Meizhou People’s Hospital, Room 1101, Building 9, Yujing Dongfang Field, Meijiang District, Meizhou City, Guangdong Province, 514031, People’s Republic of China, Tel +86 15807535293, Email Lishagnhuang48@126.com
Objective: To investigate the clinicopathological characteristics and survival outcomes of 305 surgically treated patients with stage IB–IIA cervical squamous cell carcinoma (CSCC).
Methods: Clinical data of 305 CSCC patients treated at our hospital from March 2015 to December 2019 were retrospectively analyzed. Clinicopathological features were summarized, prognostic factors identified, and survival outcomes assessed using Kaplan–Meier and Cox regression analyses.
Results: The most common symptoms were irregular bleeding (49.8%) and contact vaginal bleeding (35.7%). Tumors < 4 cm accounted for 75.1%, and International Federation of Gynecology and Obstetrics (FIGO) stage IIA was more frequent than stage IB (52.8% vs 47.2%). Deep stromal invasion (≥ 1/2) and lymph node metastasis were observed in 75.7% and 19.3% of patients, respectively. Ovarian preservation occurred in 12.8% of cases. Postoperative adjuvant therapy was given in 79.3% of patients, with 41.3% receiving concurrent chemoradiotherapy. Lower apparent diffusion coefficient (ADC) values were significantly associated with higher FIGO stage, deeper invasion, lymph node metastasis, and more intensive adjuvant therapy (P< 0.05). The 3-year overall survival (OS) and disease-free survival (DFS) rates were 88.5% and 84.6%, respectively. Cox analysis identified FIGO stage, lymph node metastasis, depth of invasion, and adjuvant therapy as independent prognostic factors (P< 0.05). Kaplan–Meier analysis showed significantly lower OS in patients with FIGO stage IIA, deep invasion, lymph node metastasis, and no or single-modality adjuvant therapy.
Conclusion: The pathological features of patients with CSCC are closely associated with ADC values derived from diffusion-weighted imaging (DWI). Vaginal bleeding, depth of invasion, FIGO stage, postoperative treatment, and lymph node metastasis are key prognostic factors. Patients with stage IIa, lymph node metastasis, no adjuvant therapy, or invasion depth ≥ 1/2 have a poorer prognosis.
Keywords: cervical squamous cell carcinoma, Phase Ib~IIa, clinical pathology, prognosis
Department of Gynecology, Meizhou People’s Hospital, Meizhou City, Guangdong Province, 514031, People’s Republic of China
Correspondence: Tao Hou, Department of Gynecology, Meizhou People’s Hospital, Room 1101, Building 9, Yujing Dongfang Field, Meijiang District, Meizhou City, Guangdong Province, 514031, People’s Republic of China, Tel +86 15807535293, Email Lishagnhuang48@126.com
Objective: To investigate the clinicopathological characteristics and survival outcomes of 305 surgically treated patients with stage IB–IIA cervical squamous cell carcinoma (CSCC).
Methods: Clinical data of 305 CSCC patients treated at our hospital from March 2015 to December 2019 were retrospectively analyzed. Clinicopathological features were summarized, prognostic factors identified, and survival outcomes assessed using Kaplan–Meier and Cox regression analyses.
Results: The most common symptoms were irregular bleeding (49.8%) and contact vaginal bleeding (35.7%). Tumors < 4 cm accounted for 75.1%, and International Federation of Gynecology and Obstetrics (FIGO) stage IIA was more frequent than stage IB (52.8% vs 47.2%). Deep stromal invasion (≥ 1/2) and lymph node metastasis were observed in 75.7% and 19.3% of patients, respectively. Ovarian preservation occurred in 12.8% of cases. Postoperative adjuvant therapy was given in 79.3% of patients, with 41.3% receiving concurrent chemoradiotherapy. Lower apparent diffusion coefficient (ADC) values were significantly associated with higher FIGO stage, deeper invasion, lymph node metastasis, and more intensive adjuvant therapy (P< 0.05). The 3-year overall survival (OS) and disease-free survival (DFS) rates were 88.5% and 84.6%, respectively. Cox analysis identified FIGO stage, lymph node metastasis, depth of invasion, and adjuvant therapy as independent prognostic factors (P< 0.05). Kaplan–Meier analysis showed significantly lower OS in patients with FIGO stage IIA, deep invasion, lymph node metastasis, and no or single-modality adjuvant therapy.
Conclusion: The pathological features of patients with CSCC are closely associated with ADC values derived from diffusion-weighted imaging (DWI). Vaginal bleeding, depth of invasion, FIGO stage, postoperative treatment, and lymph node metastasis are key prognostic factors. Patients with stage IIa, lymph node metastasis, no adjuvant therapy, or invasion depth ≥ 1/2 have a poorer prognosis.
Keywords: cervical squamous cell carcinoma, Phase Ib~IIa, clinical pathology, prognosis