109182
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
老年自发性脑出血患者内镜手术与传统开颅手术治疗的神经因子变化及预后比较
Authors Lei C, Li C, Chen X, Zhou G, Zheng X, Zhang Z, Qu X
Received 13 February 2025
Accepted for publication 1 June 2025
Published 24 October 2025 Volume 2025:21 Pages 1509—1519
DOI https://doi.org/10.2147/TCRM.S521299
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Professor Garry Walsh
Chao Lei,1,2 Chong Li,1,2 Xing Chen,1,2 Gaosheng Zhou,1,2 Xiaxia Zheng,1,2 Zhaohui Zhang,1,2 Xingguang Qu1,2
1Department of Critical Care Medicine, The First College of Clinical Medical Science, China Three Gorges University, Yichang, People’s Republic of China; 2Department of Critical Care Medicine, Yichang Central People’s Hospital, Yichang, People’s Republic of China
Correspondence: Xingguang Qu, Email cbgs295@163.com Zhaohui Zhang, Email ptr532@126.com
Objective: To compare the clinical efficacy, neurofactor changes, and prognosis in elderly patients with spontaneous intracerebral hemorrhage (ICH) treated with endoscopic surgery versus conventional craniotomy.
Methods: A retrospective analysis was conducted on 88 elderly patients with spontaneous ICH admitted from July 2021 to April 2024. Based on surgical method, patients were assigned to either the conventional craniotomy group (n=44) or the endoscopic surgery group (n=44). Surgical efficacy (hematoma evacuation rate, surgical duration, intraoperative blood loss), short-term prognosis (ICU stay, hospital stay, GOS, NIHSS, ADL scores), serum neurofactors (SOD, NSE, NGF, BDNF), inflammatory markers (WBC, CRP, PCT), and complication rates were compared.
Results: (1) The endoscopic group had significantly shorter surgical time and lower blood loss than the craniotomy group (P< 0.05), with similar hematoma evacuation rates (P> 0.05). (2) ICU and hospital stays were significantly shorter in the endoscopic group (P< 0.05). Postoperative GOS and ADL scores were higher, and NIHSS scores were lower in the endoscopic group at 3 months (P< 0.05). (3) Compared with preoperative levels, both groups showed a decreasing trend in SOD and NSE and an increasing trend in NGF and BDNF after surgery, with the observation group showing more significant and sustained changes over time (P < 0.05). (4) Although postoperative inflammatory markers increased in both groups, the observation group had milder elevations and faster downward trends (P < 0.05). (5) The complication rate was lower in the endoscopic group (6.82% vs 22.73%, P< 0.05).
Conclusion: Compared to conventional craniotomy, endoscopic hematoma evacuation in elderly ICH patients results in milder inflammatory responses, more favorable neurofactor changes, fewer complications, and improved recovery. However, these findings require further validation due to the retrospective design and limited sample size.
Keywords: spontaneous intracerebral hemorrhage, elderly, endoscopic surgery, neurofactors, prognosis
1Department of Critical Care Medicine, The First College of Clinical Medical Science, China Three Gorges University, Yichang, People’s Republic of China; 2Department of Critical Care Medicine, Yichang Central People’s Hospital, Yichang, People’s Republic of China
Correspondence: Xingguang Qu, Email cbgs295@163.com Zhaohui Zhang, Email ptr532@126.com
Objective: To compare the clinical efficacy, neurofactor changes, and prognosis in elderly patients with spontaneous intracerebral hemorrhage (ICH) treated with endoscopic surgery versus conventional craniotomy.
Methods: A retrospective analysis was conducted on 88 elderly patients with spontaneous ICH admitted from July 2021 to April 2024. Based on surgical method, patients were assigned to either the conventional craniotomy group (n=44) or the endoscopic surgery group (n=44). Surgical efficacy (hematoma evacuation rate, surgical duration, intraoperative blood loss), short-term prognosis (ICU stay, hospital stay, GOS, NIHSS, ADL scores), serum neurofactors (SOD, NSE, NGF, BDNF), inflammatory markers (WBC, CRP, PCT), and complication rates were compared.
Results: (1) The endoscopic group had significantly shorter surgical time and lower blood loss than the craniotomy group (P< 0.05), with similar hematoma evacuation rates (P> 0.05). (2) ICU and hospital stays were significantly shorter in the endoscopic group (P< 0.05). Postoperative GOS and ADL scores were higher, and NIHSS scores were lower in the endoscopic group at 3 months (P< 0.05). (3) Compared with preoperative levels, both groups showed a decreasing trend in SOD and NSE and an increasing trend in NGF and BDNF after surgery, with the observation group showing more significant and sustained changes over time (P < 0.05). (4) Although postoperative inflammatory markers increased in both groups, the observation group had milder elevations and faster downward trends (P < 0.05). (5) The complication rate was lower in the endoscopic group (6.82% vs 22.73%, P< 0.05).
Conclusion: Compared to conventional craniotomy, endoscopic hematoma evacuation in elderly ICH patients results in milder inflammatory responses, more favorable neurofactor changes, fewer complications, and improved recovery. However, these findings require further validation due to the retrospective design and limited sample size.
Keywords: spontaneous intracerebral hemorrhage, elderly, endoscopic surgery, neurofactors, prognosis