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已发表论文
在中国，如何通过韧性缓解体外受精 - 胚胎移植失败后的抑郁：希望、社会关系和收入的调节中介模型
Authors Wang X, Yang M, Zhang Y, Zhang Y , Lin Y , Sun S, Jiang L
Received 26 June 2025
Accepted for publication 14 October 2025
Published 25 October 2025 Volume 2025:17 Pages 3865—3879
DOI https://doi.org/10.2147/IJWH.S549816
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Everett Magann
Xiaoyu Wang,1 Mengye Yang,2 Yan Zhang,2 Yan Zhang,1 Yiwen Lin,1 Shijing Sun,1 Ling Jiang1
1Department of Nursing, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, People’s Republic of China; 2Reproductive Genetic Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, People’s Republic of China
Correspondence: Ling Jiang, Department of Nursing, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, 26th Daoqian Road, Suzhou, 215000, People’s Republic of China, Email jiangling877@126.com Mengye Yang, Reproductive Genetic Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, 26th Daoqian Road, Suzhou, 215000, People’s Republic of China, Email 295298077@qq.com
Background: Failed in vitro fertilization–embryo transfer (IVF-ET) cycles may exacerbate depressive symptoms among women. Resilience is widely recognized as a protective factor for psychological well-being. However, its role in alleviating depressive symptoms among women failed IVF-ET cycles in China remains insufficiently explored.
Purpose: To explore how resilience affects depressive symptoms among women failed IVF-ET cycles in China, where strong emphasis is placed on family lineage.
Patients and Methods: The cross-sectional study included 315 women failed IVF-ET cycles between June and December 2024. The 10-item Connor-Davidson Resilience Scale, the Patient Health Questionnaire, the Chinese version of the Herth Hope Index, and the social and marital relations subscales of the Fertility Quality of Life Scale were used for measurements. A moderated mediation model was tested in Mplus 8.3 to examine the direct and indirect effects of resilience on depressive symptoms, with hope and social relations as mediators and household income and healthcare payment methods as moderators.
Results: Resilience is negatively related to depressive symptoms, with hope and social relations acting as mediators. Additionally, household income moderates the pathway through which resilience influences depressive symptoms via hope, whereas the method of healthcare payment does not exhibit a moderating effect.
Conclusion: Resilience plays a critical role in mitigating depressive symptoms among women failed IVF-ET cycles in China, exerting both direct and indirect effects through the pathways of hope and social relations. Socioeconomic factors also serve as moderators in this process. To effectively support this population, the health system should integrate cultural context into the design of interventions by providing targeted psychological and social support and advocating for policy-level economic assistance.
Keywords: depressive symptoms, resilience, failed IVF-ET cycles, mental health, socioeconomic factors
1Department of Nursing, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, People’s Republic of China; 2Reproductive Genetic Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, People’s Republic of China
Correspondence: Ling Jiang, Department of Nursing, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, 26th Daoqian Road, Suzhou, 215000, People’s Republic of China, Email jiangling877@126.com Mengye Yang, Reproductive Genetic Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, 26th Daoqian Road, Suzhou, 215000, People’s Republic of China, Email 295298077@qq.com
Background: Failed in vitro fertilization–embryo transfer (IVF-ET) cycles may exacerbate depressive symptoms among women. Resilience is widely recognized as a protective factor for psychological well-being. However, its role in alleviating depressive symptoms among women failed IVF-ET cycles in China remains insufficiently explored.
Purpose: To explore how resilience affects depressive symptoms among women failed IVF-ET cycles in China, where strong emphasis is placed on family lineage.
Patients and Methods: The cross-sectional study included 315 women failed IVF-ET cycles between June and December 2024. The 10-item Connor-Davidson Resilience Scale, the Patient Health Questionnaire, the Chinese version of the Herth Hope Index, and the social and marital relations subscales of the Fertility Quality of Life Scale were used for measurements. A moderated mediation model was tested in Mplus 8.3 to examine the direct and indirect effects of resilience on depressive symptoms, with hope and social relations as mediators and household income and healthcare payment methods as moderators.
Results: Resilience is negatively related to depressive symptoms, with hope and social relations acting as mediators. Additionally, household income moderates the pathway through which resilience influences depressive symptoms via hope, whereas the method of healthcare payment does not exhibit a moderating effect.
Conclusion: Resilience plays a critical role in mitigating depressive symptoms among women failed IVF-ET cycles in China, exerting both direct and indirect effects through the pathways of hope and social relations. Socioeconomic factors also serve as moderators in this process. To effectively support this population, the health system should integrate cultural context into the design of interventions by providing targeted psychological and social support and advocating for policy-level economic assistance.
Keywords: depressive symptoms, resilience, failed IVF-ET cycles, mental health, socioeconomic factors