109182
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
金属有机框架作为先进的基因传递载体：机制、功能化及生物医学应用
Authors Guo Y, Wu H, Mao X, Li Y, Zhu W
Received 15 July 2025
Accepted for publication 9 October 2025
Published 25 October 2025 Volume 2025:20 Pages 12939—12958
DOI https://doi.org/10.2147/IJN.S553945
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Professor Eng San Thian
Yang Guo,1,2,* Hao Wu,1,* Xinyu Mao,1,2 Yawei Li,1 Wenhe Zhu1
1Research and Experimental Center, Jilin Medical University, Jilin, People’s Republic of China; 2Department of Biochemistry and Molecular Biology, Medical College of Yanbian University, Yanji, Jilin, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yawei Li, Research and Experimental Center, Jilin Medical University, No. 5 Jilin Street, Fengman District, Jilin, 132013, People’s Republic of China, Email lyw135@163.com Wenhe Zhu, Research and Experimental Center, Jilin Medical University, No. 5 Jilin Street, Fengman District, Jilin, 132013, People’s Republic of China, Email huolizwh@163.com
Abstract: Gene therapy has emerged as a transformative therapeutic strategy for addressing genetic disorders, refractory cancers, and infectious diseases; however, its clinical translation is significantly hindered by the lack of efficient, safe, and targeted gene delivery vectors. Conventional viral vectors are limited by immune rejection, narrow packaging capacity, and potential biosafety risks, while early nonviral vectors often suffer from poor targeting ability, low intracellular delivery efficiency, and insufficient protection of genetic cargo. Thus, the development of advanced gene delivery vectors is critical to overcoming these bottlenecks, safeguarding the stability and bioavailability of genetic materials, and unlocking the full therapeutic potential of gene-based therapies. Metal-organic frameworks (MOFs) are a new type of porous nanomaterial with substantial potential for use in gene delivery due to their large specific surface area, tunable pore size, good biocompatibility, and low toxicity. Here, we present a comprehensive review of MOF synthesis strategies, gene delivery mechanisms, and associated progress in biomedical applications. Genes can be effectively loaded onto MOFs through pore encapsulation, surface adsorption, covalent binding, and in situ encapsulation. Subsequently, surface functionalization methods are used to achieve precise delivery. In tumor-targeted therapy, MOFs can specifically recognize cancer cells and release genes in response to the microenvironment, thereby significantly inhibiting tumor growth. In the field of immune regulation, MOF multifunctionality supports the codelivery of genes and immune drugs, synergistically enhancing the antitumor immune response. However, challenges remain in the clinical application of MOFs, including insufficient biostability, low intracellular delivery efficiency, and potential toxicity. These challenges are expected to be addressed in the future through the development of new stable MOF materials, the optimization of surface engineering strategies, and the construction of intelligent responsive systems, yielding more precise and efficient gene therapy development.
Keywords: MOFs, gene therapy, tumor therapy, biomedical applications
1Research and Experimental Center, Jilin Medical University, Jilin, People’s Republic of China; 2Department of Biochemistry and Molecular Biology, Medical College of Yanbian University, Yanji, Jilin, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yawei Li, Research and Experimental Center, Jilin Medical University, No. 5 Jilin Street, Fengman District, Jilin, 132013, People’s Republic of China, Email lyw135@163.com Wenhe Zhu, Research and Experimental Center, Jilin Medical University, No. 5 Jilin Street, Fengman District, Jilin, 132013, People’s Republic of China, Email huolizwh@163.com
Abstract: Gene therapy has emerged as a transformative therapeutic strategy for addressing genetic disorders, refractory cancers, and infectious diseases; however, its clinical translation is significantly hindered by the lack of efficient, safe, and targeted gene delivery vectors. Conventional viral vectors are limited by immune rejection, narrow packaging capacity, and potential biosafety risks, while early nonviral vectors often suffer from poor targeting ability, low intracellular delivery efficiency, and insufficient protection of genetic cargo. Thus, the development of advanced gene delivery vectors is critical to overcoming these bottlenecks, safeguarding the stability and bioavailability of genetic materials, and unlocking the full therapeutic potential of gene-based therapies. Metal-organic frameworks (MOFs) are a new type of porous nanomaterial with substantial potential for use in gene delivery due to their large specific surface area, tunable pore size, good biocompatibility, and low toxicity. Here, we present a comprehensive review of MOF synthesis strategies, gene delivery mechanisms, and associated progress in biomedical applications. Genes can be effectively loaded onto MOFs through pore encapsulation, surface adsorption, covalent binding, and in situ encapsulation. Subsequently, surface functionalization methods are used to achieve precise delivery. In tumor-targeted therapy, MOFs can specifically recognize cancer cells and release genes in response to the microenvironment, thereby significantly inhibiting tumor growth. In the field of immune regulation, MOF multifunctionality supports the codelivery of genes and immune drugs, synergistically enhancing the antitumor immune response. However, challenges remain in the clinical application of MOFs, including insufficient biostability, low intracellular delivery efficiency, and potential toxicity. These challenges are expected to be addressed in the future through the development of new stable MOF materials, the optimization of surface engineering strategies, and the construction of intelligent responsive systems, yielding more precise and efficient gene therapy development.
Keywords: MOFs, gene therapy, tumor therapy, biomedical applications