109182
论文已发表
注册即可获取德孚的最新动态
IF 收录期刊
- 3.4 Breast Cancer (Dove Med Press)
- 3.2 Clin Epidemiol
- 2.6 Cancer Manag Res
- 2.9 Infect Drug Resist
- 3.7 Clin Interv Aging
- 5.1 Drug Des Dev Ther
- 3.1 Int J Chronic Obstr
- 6.6 Int J Nanomed
- 2.6 Int J Women's Health
- 2.9 Neuropsych Dis Treat
- 2.8 OncoTargets Ther
- 2.0 Patient Prefer Adher
- 2.2 Ther Clin Risk Manag
- 2.5 J Pain Res
- 3.0 Diabet Metab Synd Ob
- 3.2 Psychol Res Behav Ma
- 3.4 Nat Sci Sleep
- 1.8 Pharmgenomics Pers Med
- 2.0 Risk Manag Healthc Policy
- 4.1 J Inflamm Res
- 2.0 Int J Gen Med
- 3.4 J Hepatocell Carcinoma
- 3.0 J Asthma Allergy
- 2.2 Clin Cosmet Investig Dermatol
- 2.4 J Multidiscip Healthc
已发表论文
关于元认知训练对不同类型精神分裂症阴性症状治疗效果的研究
Authors Shen L, Yan J , Xiao W, Sun L, Du M, He Y
Received 21 June 2025
Accepted for publication 17 October 2025
Published 25 October 2025 Volume 2025:18 Pages 2225—2235
DOI https://doi.org/10.2147/PRBM.S548616
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Bao-Liang Zhong
Lijuan Shen,1,* Jing Yan,2,* Weixia Xiao,3 Lixin Sun,3 Mingjun Du,3 Yiqun He3
1Department of Clinical Psychology, the Second Affiliated Hospital of Xinxiang Medical University (Henan Mental Hospital), Xinxiang Key Laboratory of Diagnosis and Treatment Technology of Psychosomatic Diseases, Xinxiang, Henan, People’s Republic of China; 2Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, People’s Republic of China; 3The Second Affiliated Hospital of Xinxiang Medical University (Henan Mental Hospital), Xinxiang, Henan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Lijuan Shen, Department of Clinical Psychology, the Second Affiliated Hospital of Xinxiang Medical University (Henan Mental Hospital), Xinxiang Key Laboratory of Diagnosis and Treatment Technology of Psychosomatic Diseases, Xinxiang, Henan, 453002, People’s Republic of China, Email yalinzhang7708@163.com Jing Yan, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, People’s Republic of China, Email yanj@bjmu.edu.cn
Purpose: This study aims to investigate the efficacy of metacognitive training (MCT) as an adjunctive treatment strategy for schizophrenia, particularly its impact on negative symptoms and potential mechanisms.
Patients and Methods: This study included a total of 73 inpatients with schizophrenia. 36 patients were in the MCT group and 37 patients were in the control group. Both groups of patients were receiving a single second-generation antipsychotic drug treatment. The MCT group underwent a 4-week MCT program consisting of 8 modules, while the control group received non-cognitive psychological support for the same duration and frequency. The Positive and Negative Syndrome Scale (PANSS) five-factor model and negative symptom two-factor model were used to assess psychiatric symptoms, and the Snyder’s Self-Monitoring Scale (SSMS) and the Personal and Social Performance Scale (PSP) were used as functional evaluation indicators.
Results: After treatment, compared to the control group, the MCT group had significantly lower scores in the PANSS total score (p< 0.001), negative factor (p=0.002), and hostility factor (p=0.046). Further, the PSP score (p< 0.001) and SSMS score (p=0.042) were significantly improved. In the two-factor analysis of negative symptoms, the MCT group showed significant improvements in both diminished expression (DE) symptoms (p< 0.001) and social amotivation (SA) symptoms (p=0.010) after treatment. Multivariate linear regression analysis revealed that changes in the reduction rates of P2 (Conceptual disorganization), N7 (stereotyped thinking), and SA scores had a significant impact on the reduction in DE scores; changes in the reduction rates of P6 (Suspiciousness/persecution) and DE scores had a significant impact on the reduction rate of SA scores (p< 0.05).
Conclusion: MCT can improve the clinical symptoms and functions of patients with schizophrenia, especially in the DE factor characterized by conceptual disorganization and stereotyped thinking, and the SA factor prominent in suspiciousness/persecution symptom. This provides insights for the precise treatment of negative symptoms.
Keywords: metacognitive training, schizophrenia, negative symptoms, diminished expression, social amotivation
1Department of Clinical Psychology, the Second Affiliated Hospital of Xinxiang Medical University (Henan Mental Hospital), Xinxiang Key Laboratory of Diagnosis and Treatment Technology of Psychosomatic Diseases, Xinxiang, Henan, People’s Republic of China; 2Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, People’s Republic of China; 3The Second Affiliated Hospital of Xinxiang Medical University (Henan Mental Hospital), Xinxiang, Henan, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Lijuan Shen, Department of Clinical Psychology, the Second Affiliated Hospital of Xinxiang Medical University (Henan Mental Hospital), Xinxiang Key Laboratory of Diagnosis and Treatment Technology of Psychosomatic Diseases, Xinxiang, Henan, 453002, People’s Republic of China, Email yalinzhang7708@163.com Jing Yan, Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, People’s Republic of China, Email yanj@bjmu.edu.cn
Purpose: This study aims to investigate the efficacy of metacognitive training (MCT) as an adjunctive treatment strategy for schizophrenia, particularly its impact on negative symptoms and potential mechanisms.
Patients and Methods: This study included a total of 73 inpatients with schizophrenia. 36 patients were in the MCT group and 37 patients were in the control group. Both groups of patients were receiving a single second-generation antipsychotic drug treatment. The MCT group underwent a 4-week MCT program consisting of 8 modules, while the control group received non-cognitive psychological support for the same duration and frequency. The Positive and Negative Syndrome Scale (PANSS) five-factor model and negative symptom two-factor model were used to assess psychiatric symptoms, and the Snyder’s Self-Monitoring Scale (SSMS) and the Personal and Social Performance Scale (PSP) were used as functional evaluation indicators.
Results: After treatment, compared to the control group, the MCT group had significantly lower scores in the PANSS total score (p< 0.001), negative factor (p=0.002), and hostility factor (p=0.046). Further, the PSP score (p< 0.001) and SSMS score (p=0.042) were significantly improved. In the two-factor analysis of negative symptoms, the MCT group showed significant improvements in both diminished expression (DE) symptoms (p< 0.001) and social amotivation (SA) symptoms (p=0.010) after treatment. Multivariate linear regression analysis revealed that changes in the reduction rates of P2 (Conceptual disorganization), N7 (stereotyped thinking), and SA scores had a significant impact on the reduction in DE scores; changes in the reduction rates of P6 (Suspiciousness/persecution) and DE scores had a significant impact on the reduction rate of SA scores (p< 0.05).
Conclusion: MCT can improve the clinical symptoms and functions of patients with schizophrenia, especially in the DE factor characterized by conceptual disorganization and stereotyped thinking, and the SA factor prominent in suspiciousness/persecution symptom. This provides insights for the precise treatment of negative symptoms.
Keywords: metacognitive training, schizophrenia, negative symptoms, diminished expression, social amotivation