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已发表论文
工程化多功能纳米酶以重编程慢性伤口中的氧化应激和炎症反应
Authors Li Q, Zheng W, Cheng J, Li B, Lei Y, Guo H, Xv Y, Huang J, Liao X
Received 8 June 2025
Accepted for publication 22 October 2025
Published 27 October 2025 Volume 2025:20 Pages 12993—13006
DOI https://doi.org/10.2147/IJN.S545569
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 4
Editor who approved publication: Professor Dong Wang
Qingyan Li,1,* Weilin Zheng,2,* Jingge Cheng,1,* Bo Li,1 Yutian Lei,1 Huilong Guo,1 Youshan Xv,3 Jiaming Huang,4 Xiaoxing Liao1,5
1Emergency and Disaster Medicine center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong Province, People’s Republic of China; 2Department of Hepatobiliary and Gastrointestinal Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, People’s Republic of China; 3The Huiqiao Medical Center (International Medical Service) of Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China; 4Department of Hepatobiliary and Gastrointestinal Surgery, Shenzhen Guangming District People’s Hospital, Shenzhen, Guangdong Province, People’s Republic of China; 5The Institute of Emergency Care and Resuscitation, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong Province, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaoxing Liao, Email liaowens@163.com Jiaming Huang, Email huangjiaming@szgmrmyy.cn
Introduction: Diabetic wounds represent a growing clinical challenge worldwide, characterized by persistent immune dysregulation and excessive inflammation that lead to impaired healing and chronic progression.
Methods: To address this, we developed a composite nanosystem, termed Ru@ACEI, composed of ruthenium-incorporated hollow mesoporous silica nanoparticles loaded with angiotensin-converting enzyme inhibitors (ACEIs).
Results: The Ru@ACEI nanoparticles exhibit dual enzyme-mimetic activities (superoxide dismutase and catalase), effectively scavenging excess reactive oxygen species (ROS). This activity reduces cellular apoptosis and promotes endothelial cell proliferation. Following cellular uptake, Ru@ACEI catalyzes the decomposition of peroxides into water and oxygen, thereby suppressing the NLRP3/Caspase-3/Caspase-9 apoptosis pathway. The consequent improvement in endothelial cell survival helps reverse local hyperinflammation in diabetic wounds.
Conclusion: Collectively, these findings demonstrate that the Ru@ACEI nanosystem accelerates diabetic wound healing by mitigating the inflammatory microenvironment and downregulating the expression of pro-inflammatory factors, offering a promising therapeutic strategy for managing chronic diabetic wounds.
Keywords: diabetic wound, nanoenzyme, apoptosis, ROS-scavenge, anti-inflammatory microenvironment
1Emergency and Disaster Medicine center, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong Province, People’s Republic of China; 2Department of Hepatobiliary and Gastrointestinal Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, People’s Republic of China; 3The Huiqiao Medical Center (International Medical Service) of Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, People’s Republic of China; 4Department of Hepatobiliary and Gastrointestinal Surgery, Shenzhen Guangming District People’s Hospital, Shenzhen, Guangdong Province, People’s Republic of China; 5The Institute of Emergency Care and Resuscitation, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, Guangdong Province, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Xiaoxing Liao, Email liaowens@163.com Jiaming Huang, Email huangjiaming@szgmrmyy.cn
Introduction: Diabetic wounds represent a growing clinical challenge worldwide, characterized by persistent immune dysregulation and excessive inflammation that lead to impaired healing and chronic progression.
Methods: To address this, we developed a composite nanosystem, termed Ru@ACEI, composed of ruthenium-incorporated hollow mesoporous silica nanoparticles loaded with angiotensin-converting enzyme inhibitors (ACEIs).
Results: The Ru@ACEI nanoparticles exhibit dual enzyme-mimetic activities (superoxide dismutase and catalase), effectively scavenging excess reactive oxygen species (ROS). This activity reduces cellular apoptosis and promotes endothelial cell proliferation. Following cellular uptake, Ru@ACEI catalyzes the decomposition of peroxides into water and oxygen, thereby suppressing the NLRP3/Caspase-3/Caspase-9 apoptosis pathway. The consequent improvement in endothelial cell survival helps reverse local hyperinflammation in diabetic wounds.
Conclusion: Collectively, these findings demonstrate that the Ru@ACEI nanosystem accelerates diabetic wound healing by mitigating the inflammatory microenvironment and downregulating the expression of pro-inflammatory factors, offering a promising therapeutic strategy for managing chronic diabetic wounds.
Keywords: diabetic wound, nanoenzyme, apoptosis, ROS-scavenge, anti-inflammatory microenvironment