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已发表论文
一氧化氮在变应性鼻炎中的双重作用：从 NO/cGMP 信号通路到可能的新治疗靶点——针对细胞器损伤
Received 24 July 2025
Accepted for publication 18 October 2025
Published 27 October 2025 Volume 2025:18 Pages 14989—15001
DOI https://doi.org/10.2147/JIR.S556042
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Tara Strutt
Wei Wang,1 Lexin Wang,2 Haonan Lin3
1Department of Otorhinolaryngology, Shaoxing People’s Hospital, Shaoxing, People’s Republic of China; 2Western Institute of Digital-Intelligent Medicine, Chongqing Medical University, Chongqing, People’s Republic of China; 3Department of Otolaryngology, Affiliated Hospital of Shaoxing University, Shaoxing, People’s Republic of China
Correspondence: Haonan Lin, Department of Otolaryngology, Affiliated Hospital of Shaoxing University, Shaoxing, People’s Republic of China, Email 954550407@qq.com
Abstract: Allergic rhinitis (AR) is a chronic, non-infectious condition mediated by IgE that primarily affects the nasal mucosa. Recent studies have indicated a relationship between nitric oxide (NO) and the pathogenesis of allergic rhinitis. This review integrates the NO/cGMP pathway with mitochondrial, endoplasmic reticulum, and lysosomal pathways, as well as related translational targets, aiming to systematically dissect the associations between these pathways and their roles in AR. By synthesizing literature from the PubMed database (1994– 2024), we conducted an in-depth analysis of the specific mechanisms by which homeostatic NO and pathological NO contribute to the pathogenesis of AR. Additionally, we investigate the impact of the NO derivative peroxynitrite on mitochondrial, endoplasmic reticulum, and lysosomal organelles. Based on these findings, we further explore potential treatment modalities for AR.
Keywords: nitric oxide, NO/cGMP, allergic rhinitis, peroxynitrite, cellular components
1Department of Otorhinolaryngology, Shaoxing People’s Hospital, Shaoxing, People’s Republic of China; 2Western Institute of Digital-Intelligent Medicine, Chongqing Medical University, Chongqing, People’s Republic of China; 3Department of Otolaryngology, Affiliated Hospital of Shaoxing University, Shaoxing, People’s Republic of China
Correspondence: Haonan Lin, Department of Otolaryngology, Affiliated Hospital of Shaoxing University, Shaoxing, People’s Republic of China, Email 954550407@qq.com
Abstract: Allergic rhinitis (AR) is a chronic, non-infectious condition mediated by IgE that primarily affects the nasal mucosa. Recent studies have indicated a relationship between nitric oxide (NO) and the pathogenesis of allergic rhinitis. This review integrates the NO/cGMP pathway with mitochondrial, endoplasmic reticulum, and lysosomal pathways, as well as related translational targets, aiming to systematically dissect the associations between these pathways and their roles in AR. By synthesizing literature from the PubMed database (1994– 2024), we conducted an in-depth analysis of the specific mechanisms by which homeostatic NO and pathological NO contribute to the pathogenesis of AR. Additionally, we investigate the impact of the NO derivative peroxynitrite on mitochondrial, endoplasmic reticulum, and lysosomal organelles. Based on these findings, we further explore potential treatment modalities for AR.
Keywords: nitric oxide, NO/cGMP, allergic rhinitis, peroxynitrite, cellular components