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已发表论文
乳酰化相关基因 CALM1 通过免疫微环境重塑促进主动脉夹层：来自生物信息学和临床证据的见解
Authors Yu Z, Pan Y, Qian X, Zhang X, Zhu Z, Xue Q, Xiao W
Received 12 May 2025
Accepted for publication 11 August 2025
Published 27 October 2025 Volume 2025:18 Pages 14891—14911
DOI https://doi.org/10.2147/JIR.S539938
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Qing Lin
Zhiming Yu,* Yue Pan,* Xiaoyu Qian,* Xuesong Zhang, Zhen Zhu, Qun Xue, Weizhang Xiao
Department of Cardiovascular Surgery, Affiliated Hospital and Medical School of Nantong University, Nantong, 226001, China
*These authors contributed equally to this work
Correspondence: Qun Xue, Email 13962800698@163.com Weizhang Xiao, Email xwz191201@163.com
Background: Aortic dissection (AD) represents a life-threatening cardiovascular condition with a high mortality rate. Extensive research has implicated inflammation as a pivotal factor in the development of aortic dissection. Lactylation, a process implicated in various inflammatory responses, play a critical role in several cardiovascular diseases. However, the specific role of lactylation-related genes in the pathogenesis of AD remains largely unexplored.
Methods: We downloaded and integrated two AD-related datasets (GSE 52093 and GSE 98770) from the GEO database. Subsequently, we pinpointed hub genes associated with lactylation, conducted a comprehensive analysis of their functional implications, and examine the correlation between their expression levels and immune infiltration. Furthermore, we utilized single-cell sequencing data to compare the lactylation levels across various immune cell types between AD patients and healthy individuals.
Results: Our analysis identified three hub genes (CALM1, PARP1, and PTBP1) that are strongly associated with lactylation in AD. Importantly, we found a robust correlation between the expression levels of these hub genes and the extent of immune cell infiltration. Single-cell sequencing data further highlighted marked differences in lactylation levels among diverse immune cell types between AD patients and healthy individuals. Notably, the lactylation levels of immune cells in the aortic tissues of AD patients were significantly elevated. In clinical sample validation, the expression of CALM1, but not PARP1 and PTBP1, showed significant differences between the two groups.
Conclusion: Our study unveils significant differences in lactylation levels within the immune cells of aortic tissue between AD patients and healthy individuals. Moreover, we provide experimental validation that the lactylation-related gene CALM1 may serve as a promising biomarker for the diagnosis of AD, offering new insights into the pathogenesis and potential diagnostic approaches for this deadly condition.
Keywords: aortic dissection, lactylation, immune infiltration, biomarker, molecular docking
Department of Cardiovascular Surgery, Affiliated Hospital and Medical School of Nantong University, Nantong, 226001, China
*These authors contributed equally to this work
Correspondence: Qun Xue, Email 13962800698@163.com Weizhang Xiao, Email xwz191201@163.com
Background: Aortic dissection (AD) represents a life-threatening cardiovascular condition with a high mortality rate. Extensive research has implicated inflammation as a pivotal factor in the development of aortic dissection. Lactylation, a process implicated in various inflammatory responses, play a critical role in several cardiovascular diseases. However, the specific role of lactylation-related genes in the pathogenesis of AD remains largely unexplored.
Methods: We downloaded and integrated two AD-related datasets (GSE 52093 and GSE 98770) from the GEO database. Subsequently, we pinpointed hub genes associated with lactylation, conducted a comprehensive analysis of their functional implications, and examine the correlation between their expression levels and immune infiltration. Furthermore, we utilized single-cell sequencing data to compare the lactylation levels across various immune cell types between AD patients and healthy individuals.
Results: Our analysis identified three hub genes (CALM1, PARP1, and PTBP1) that are strongly associated with lactylation in AD. Importantly, we found a robust correlation between the expression levels of these hub genes and the extent of immune cell infiltration. Single-cell sequencing data further highlighted marked differences in lactylation levels among diverse immune cell types between AD patients and healthy individuals. Notably, the lactylation levels of immune cells in the aortic tissues of AD patients were significantly elevated. In clinical sample validation, the expression of CALM1, but not PARP1 and PTBP1, showed significant differences between the two groups.
Conclusion: Our study unveils significant differences in lactylation levels within the immune cells of aortic tissue between AD patients and healthy individuals. Moreover, we provide experimental validation that the lactylation-related gene CALM1 may serve as a promising biomarker for the diagnosis of AD, offering new insights into the pathogenesis and potential diagnostic approaches for this deadly condition.
Keywords: aortic dissection, lactylation, immune infiltration, biomarker, molecular docking