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已发表论文
肝细胞癌自发破裂：发病机制、临床管理、预后因素及未来方向
Authors Cheng Y , Ye F , Chen Y
Received 2 June 2025
Accepted for publication 10 October 2025
Published 27 October 2025 Volume 2025:12 Pages 2421—2428
DOI https://doi.org/10.2147/JHC.S540510
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Prof. Dr. Imam Waked
Yuan Cheng,1,* Feng Ye,2,* Yongjun Chen2
1Department of Medical Oncology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, People’s Republic of China; 2Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yongjun Chen, Email yongjunchen@yahoo.com
Abstract: Spontaneous rupture of hepatocellular carcinoma (srHCC) is a life-threatening complication with complex pathophysiology and heterogeneous clinical presentations. This review aims to provide an up-to-date summary of the pathogenesis, clinical features, treatment strategies, prognostic factors, and emerging research in srHCC. We discuss current understanding of risk factors and rupture mechanisms, outline diagnostic and therapeutic approaches—including surgical, interventional, and systemic options—and explore postoperative management and prognosis. We also highlight recent clinical evidence and unmet research needs. Understanding the multifaceted nature of srHCC is essential to improve outcomes and guide future research directions.
Keywords: spontaneous rupture, hepatocellular carcinoma, TACE, conversion therapy, prognosis, adjuvant therapy
1Department of Medical Oncology, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210002, People’s Republic of China; 2Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Yongjun Chen, Email yongjunchen@yahoo.com
Abstract: Spontaneous rupture of hepatocellular carcinoma (srHCC) is a life-threatening complication with complex pathophysiology and heterogeneous clinical presentations. This review aims to provide an up-to-date summary of the pathogenesis, clinical features, treatment strategies, prognostic factors, and emerging research in srHCC. We discuss current understanding of risk factors and rupture mechanisms, outline diagnostic and therapeutic approaches—including surgical, interventional, and systemic options—and explore postoperative management and prognosis. We also highlight recent clinical evidence and unmet research needs. Understanding the multifaceted nature of srHCC is essential to improve outcomes and guide future research directions.
Keywords: spontaneous rupture, hepatocellular carcinoma, TACE, conversion therapy, prognosis, adjuvant therapy