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已发表论文
一例终末期肾病血液透析患者成功应用司库奇尤单抗治疗红皮病型银屑病的病例报告
Authors Zhang S, Liu P, Liu S, He M, Zheng S, Sun X, Qi R, Gao X, Zhu L
Received 5 June 2025
Accepted for publication 21 October 2025
Published 27 October 2025 Volume 2025:18 Pages 2829—2833
DOI https://doi.org/10.2147/CCID.S545123
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Jeffrey Weinberg
Shixuan Zhang,1 Panpan Liu,2 Sitong Liu,1 Minghuan He,1 Song Zheng,3 Xiaodong Sun,4 Ruiqun Qi,3,5 Xinghua Gao,3,5 Lili Zhu1
1Department of Dermatology, the People’s Hospital of Liaoning Province, Shenyang, Liaoning Province, 110016, People’s Republic of China; 2Department of Nephrology, the People’s Hospital of Liaoning Province, Shenyang, Liaoning Province, 110016, People’s Republic of China; 3Department of Dermatology, the First Hospital of China Medical University, Shenyang, Liaoning Province, 110000, People’s Republic of China; 4Department of Dermatology, Shenyang No. 7 People’s Hospital, Shenyang, Liaoning Province, 110000, People’s Republic of China; 5Key Laboratory of Immunodermatology, Ministry of Education, and National Health Commission; National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, 110000, People’s Republic of China
Correspondence: Lili Zhu, Department of Dermatology, the People’s Hospital of Liaoning Province, Shenyang, 110016, People’s Republic of China, Tel +86-024-24016951, Fax +86-024-24016585, Email lilizhu_cmu@hotmail.com
Abstract: Patients with erythrodermic psoriasis (EP) complicated by end-stage renal disease (ESRD) requiring hemodialysis are extremely rare in clinical practice, and treatment options for this specific population remain highly limited. Herein we report a case of an EP patient with ESRD, in whom treatment with an interleukin-17 (IL-17) inhibitor secukinumab not only rapidly alleviated erythrodermic symptoms but also resulted in a certain degree of improvement in renal function. At the 7-month follow-up, the patient maintained skin lesion clearance with no deterioration in renal function—a finding that has not been consistently documented in previous literature. This case suggests that for patients with psoriasis complicated by kidney disease IL-17 inhibitors may serve as a potentially favorable therapeutic option.
Keywords: erythrodermic psoriasis, end-stage renal disease, IL-17 inhibitor case report
1Department of Dermatology, the People’s Hospital of Liaoning Province, Shenyang, Liaoning Province, 110016, People’s Republic of China; 2Department of Nephrology, the People’s Hospital of Liaoning Province, Shenyang, Liaoning Province, 110016, People’s Republic of China; 3Department of Dermatology, the First Hospital of China Medical University, Shenyang, Liaoning Province, 110000, People’s Republic of China; 4Department of Dermatology, Shenyang No. 7 People’s Hospital, Shenyang, Liaoning Province, 110000, People’s Republic of China; 5Key Laboratory of Immunodermatology, Ministry of Education, and National Health Commission; National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, 110000, People’s Republic of China
Correspondence: Lili Zhu, Department of Dermatology, the People’s Hospital of Liaoning Province, Shenyang, 110016, People’s Republic of China, Tel +86-024-24016951, Fax +86-024-24016585, Email lilizhu_cmu@hotmail.com
Abstract: Patients with erythrodermic psoriasis (EP) complicated by end-stage renal disease (ESRD) requiring hemodialysis are extremely rare in clinical practice, and treatment options for this specific population remain highly limited. Herein we report a case of an EP patient with ESRD, in whom treatment with an interleukin-17 (IL-17) inhibitor secukinumab not only rapidly alleviated erythrodermic symptoms but also resulted in a certain degree of improvement in renal function. At the 7-month follow-up, the patient maintained skin lesion clearance with no deterioration in renal function—a finding that has not been consistently documented in previous literature. This case suggests that for patients with psoriasis complicated by kidney disease IL-17 inhibitors may serve as a potentially favorable therapeutic option.
Keywords: erythrodermic psoriasis, end-stage renal disease, IL-17 inhibitor case report