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已发表论文
琥珀酸在炎症性肠病中的双重作用：微生物群 - 代谢 - 免疫相互作用及治疗意义的叙述性综述
Authors Zhao M, Zhou C, Wang D, Wu Q, Feng B
Received 25 August 2025
Accepted for publication 13 October 2025
Published 28 October 2025 Volume 2025:18 Pages 15017—15032
DOI https://doi.org/10.2147/JIR.S561871
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 3
Editor who approved publication: Dr Nadia Andrea Andreani
Meihua Zhao,1 Chuan Zhou,1 Dandan Wang,1 Qiong Wu,2 Baisui Feng1
1Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department of Pathology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
Correspondence: Baisui Feng, Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, No. 2 Courtyard, Jingba Road, Zhengzhou, Henan, People’s Republic of China, Email fengbs@zzu.edu.cn
Abstract: Inflammatory bowel disease (IBD) is a chronic intestinal condition characterized by microbial dysbiosis, metabolic alterations, and immune dysregulation. Succinate, a key tricarboxylic acid (TCA) cycle intermediate and microbiota-derived metabolite, has emerged as a central regulator within the host microbiota-metabolism-immune axis in IBD. This narrative review delineates succinate metabolism and its dual signaling roles, operating both intracellularly and through extracellular receptors. We synthesize evidence on its context-dependent immunomodulatory functions, which can paradoxically drive both pro- and anti-inflammatory responses, and elucidate the specific factors that dictate these outcomes. Finally, we critically evaluate the translational potential of targeting the succinate pathway, outlining promising avenues for future research in IBD diagnosis and treatment.
Keywords: succinate, inflammatory bowel disease, immune regulation, microbiota-metabolism-immune axis, precision medicine
1Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China; 2Department of Pathology, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China
Correspondence: Baisui Feng, Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, No. 2 Courtyard, Jingba Road, Zhengzhou, Henan, People’s Republic of China, Email fengbs@zzu.edu.cn
Abstract: Inflammatory bowel disease (IBD) is a chronic intestinal condition characterized by microbial dysbiosis, metabolic alterations, and immune dysregulation. Succinate, a key tricarboxylic acid (TCA) cycle intermediate and microbiota-derived metabolite, has emerged as a central regulator within the host microbiota-metabolism-immune axis in IBD. This narrative review delineates succinate metabolism and its dual signaling roles, operating both intracellularly and through extracellular receptors. We synthesize evidence on its context-dependent immunomodulatory functions, which can paradoxically drive both pro- and anti-inflammatory responses, and elucidate the specific factors that dictate these outcomes. Finally, we critically evaluate the translational potential of targeting the succinate pathway, outlining promising avenues for future research in IBD diagnosis and treatment.
Keywords: succinate, inflammatory bowel disease, immune regulation, microbiota-metabolism-immune axis, precision medicine