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已发表论文
低中度近视与高度近视晶状体布里渊散射参数的比较
Authors Bao Y, Ma Y, Cao J, Yu Y, Fukuyama T, Zhang Z, Niu L , Yao P, Wang X, Zhou X , Zhao J
Received 20 July 2025
Accepted for publication 17 October 2025
Published 29 October 2025 Volume 2025:19 Pages 4001—4009
DOI https://doi.org/10.2147/OPTH.S555070
Checked for plagiarism Yes
Review by Single anonymous peer review
Peer reviewer comments 2
Editor who approved publication: Dr Scott Fraser
Yongle Bao,1– 4,* Yong Ma,1,2,* Jian Cao,5,* Yanze Yu,1,2 Teruko Fukuyama,1,2 Zhe Zhang,1,2 Lingling Niu,1,2 Peijun Yao,1,2 Xiaoying Wang,1,2 Xingtao Zhou,1,2 Jing Zhao1,2
1Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, People’s Republic of China; 2Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, NHC, Shanghai, People’s Republic of China; 3Department of Ophthalmology, Zhangye People’s Hospital, Hexi University, Zhangye, Gansu, People’s Republic of China; 4Clinical Medical College, Hexi University, Zhangye, Gansu, People’s Republic of China; 5State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jing Zhao, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People’s Republic of China, Tel +86021-64377134, Email zhaojing_med@163.com Xingtao Zhou, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People’s Republic of China, Tel +86021-64377134, Email doctzhouxingtao0308@163.com
Purpose: To investigate the impact of myopia on the Brillouin biomechanics and morphology of crystalline lenses in Chinese adults.
Methods: Patients with myopia were enrolled and divided into low-medium (spherical equivalent [SE] ≥ − 5.75 D, N = 66) and high (SE ≤ – 6.0 D, N = 72) myopia groups. All patients underwent routine ophthalmic examinations, including SE, axial length, and anterior chamber metrics (Pentacam) measurements. The Brillouin-related metrics of the crystalline lenses were measured using a Brillouin microscopy. The morphological parameters included the Width of Top Plateau (WTP), Width of Bottom Plateau (WBP), Bottom-Top (B-T), Slope of Anterior Cortex (SAC), and Slope of Posterior Cortex (SPC). The height of Plateau was a biomechanical parameter.
Results: The study included 138 eyes (138 patients); the mean age was 28.43 ± 8.31 years. WBP, B-T, SAC, and SPC significantly differed between the high and low-medium myopia groups (all P< 0.05). WBP, B-T, and SPC significantly correlated with SE in the high myopia group (Pearson’s r = 0.365, 0.287, and 0.294, respectively; all P< 0.05) but not in the low-medium group. The SPC significantly decreased for all participants based on the SE values (P< 0.05). The biomechanics and thickness of the nucleus displayed no discrepancies with SE in all participants (all P > 0.05).
Conclusion: An increase in the degree of myopia could be associated with posterior cortex thickening while maintaining stable biomechanics and morphology of the crystalline lens nucleus. Brillouin microscopy can serve as an effective technique for multidisciplinary lens biomechanical and morphological imaging.
Keywords: Brillouin microscopy, crystalline lens, myopia, morphology, biomechanics
1Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, People’s Republic of China; 2Key Laboratory of Myopia and Related Eye Diseases, Chinese Academy of Medical Sciences, NHC, Shanghai, People’s Republic of China; 3Department of Ophthalmology, Zhangye People’s Hospital, Hexi University, Zhangye, Gansu, People’s Republic of China; 4Clinical Medical College, Hexi University, Zhangye, Gansu, People’s Republic of China; 5State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, People’s Republic of China
*These authors contributed equally to this work
Correspondence: Jing Zhao, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People’s Republic of China, Tel +86021-64377134, Email zhaojing_med@163.com Xingtao Zhou, Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Road, Shanghai, 200031, People’s Republic of China, Tel +86021-64377134, Email doctzhouxingtao0308@163.com
Purpose: To investigate the impact of myopia on the Brillouin biomechanics and morphology of crystalline lenses in Chinese adults.
Methods: Patients with myopia were enrolled and divided into low-medium (spherical equivalent [SE] ≥ − 5.75 D, N = 66) and high (SE ≤ – 6.0 D, N = 72) myopia groups. All patients underwent routine ophthalmic examinations, including SE, axial length, and anterior chamber metrics (Pentacam) measurements. The Brillouin-related metrics of the crystalline lenses were measured using a Brillouin microscopy. The morphological parameters included the Width of Top Plateau (WTP), Width of Bottom Plateau (WBP), Bottom-Top (B-T), Slope of Anterior Cortex (SAC), and Slope of Posterior Cortex (SPC). The height of Plateau was a biomechanical parameter.
Results: The study included 138 eyes (138 patients); the mean age was 28.43 ± 8.31 years. WBP, B-T, SAC, and SPC significantly differed between the high and low-medium myopia groups (all P< 0.05). WBP, B-T, and SPC significantly correlated with SE in the high myopia group (Pearson’s r = 0.365, 0.287, and 0.294, respectively; all P< 0.05) but not in the low-medium group. The SPC significantly decreased for all participants based on the SE values (P< 0.05). The biomechanics and thickness of the nucleus displayed no discrepancies with SE in all participants (all P > 0.05).
Conclusion: An increase in the degree of myopia could be associated with posterior cortex thickening while maintaining stable biomechanics and morphology of the crystalline lens nucleus. Brillouin microscopy can serve as an effective technique for multidisciplinary lens biomechanical and morphological imaging.
Keywords: Brillouin microscopy, crystalline lens, myopia, morphology, biomechanics